CAS: 56843-79-9; 4-Chloro-2-Methylthieno[2,3-D]Pyrimidine

相似化合物

14080-59-2 137287-40-2 56844-11-2

上下游产品

CAS号21582-51-4 2-甲基-3,4-二氢-4-氧... | CAS号56844-01-0 2-甲基噻吩并[2,3-d]嘧啶

2-氨基噻吩-3-甲酸乙酯置于盐酸,三氯氧磷体系中,化学反应 4.5H,反应生成 4-氯-2-甲基噻吩并[2,3-D]嘧啶
参考文献: Monocyclic,Thieno,Pyrido,And Pyrrolo Pyrimidine Compounds And Methods Of Use And Manufacture Of The Same[fr] Composés De Pyrimidines Monocycliques,Thiénopyrimidines,Pyridopyrimidines,Et Pyrrolopyrimidines,Leurs Procédés D'Utilisation Et De Fabrication
标题: Monocyclic,Thieno,Pyrido,And Pyrrolo Pyrimidine Compounds And Methods Of Use And Manufacture Of The Same[fr] Composés De Pyrimidines Monocycliques,Thiénopyrimidines,Pyridopyrimidines,Et Pyrrolopyrimidines,Leurs Procédés D'Utilisation Et De Fabrication
摘要:本发明提供了单环,噻吩,吡啶和吡咯基嘧啶化合物.提供了包含这些化合物中的一个或多个的药物组合物,可选地包含一个或多个化合物的药用可接受盐或水合物.优选地,这些药物组合物进一步包含至少一种药用可接受的载体.提供了治疗患有癌症的患者的方法,其中向患者施用了这些化合物或药物组合物中的一个或多个的治疗有效量.

专利信息

专利号:WO-2024048714-A1
优先权日:2022-09-01
标 题:METHOD FOR PRODUCING 6-(4,4-DIMETHYLCYCLOHEXYL)-4-[(1,1-DIOXO-1λ6-THIOMORPHOLIN-4-YL)METHYL]-2-METHYLTHIENO[2,3-D]PYRIMIDINE OR SALT THEREOF
发明人：OTAKA ERIKO; OBITSU KAZUYOSHI; KOHMURA YOSHINORI; YAMASHITA YOHEI; TAKAMATSU YUSEI; HIRASAWA SHUN; FUKUYAMA TOHRU
权利人:ASTELLAS PHARMA INC
摘要:The present invention addresses the problem of providing a novel synthesis method for 6-(4,4-dimethylcyclohexyl)-4-[(1,1-dioxo-1λ6-thiomorpholin-4-yl)methyl]-2-methylthieno[2,3-d]pyrimidine and a salt thereof, which is efficient and is preferred from the viewpoint of green chemistry.　6-(4,4-Dimethylcyclohexyl)-4-[(1,1-dioxo-1λ6-thiomorpholin-4-yl)methyl]-2-methylthieno[2,3-d]pyrimidine is synthesized safely and efficiently by a method including a step for adding 4,4-dimethyl-cyclohexanone to position-6 in a compound represented by the formula shown below [in the formula, Hal represents a halogen atom].