CAS: 373-49-9; (Z)-Hexadec-9-Enoic Acid

该化合物是植物和动物来源,包括油和海洋油中自然产生的单饱和型美洲狮-7脂肪酸,是脂质新陈代谢的关键中间体,具有独特的生化特性,如调制胰岛素敏感性和脂质合成,其应用范围包括药物,营养学和化妆品,其潜在抗炎和皮肤阻塞效应被估价.纯度通常超过95%,高等级的棕榈油酸适合研究和配制目的,与有机溶剂的稳定性和兼容性使其成为代谢健康和皮肤学研究的多种化合物.

结构式图片

相似化合物

1120-25-8 112-86-7 5561-99-9

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

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CAS号114119-34-5 methyl 5-thiast... | CAS号124-38-9 二氧化碳 | CAS号57491-64-2 16-Iodo-(Z)-9-h... | CAS号725720-60-5 15-ethoxy-penta... | CAS号1120-25-8 棕榈油酸甲酯 | CAS号56219-10-4 顺-9-十六碳烯酸乙酯 | CAS号533-87-9 (±)-9,10,16-三羟基棕榈酸 | CAS号1619-68-7 16-Hydroxy-tran... | CAS号57491-62-0 16-tosyloxy-(Z)... | CAS号506-17-2 十八烷酸 | CAS号872-05-9 正癸烯 | CAS号14436-32-9 9-癸烯酸 | CAS号25601-41-6 9-Dec烯酸甲酯 | CAS号123-99-9 壬二酸 | CAS号111-71-7 正庚醛 | CAS号111-14-8 庚酸 | CAS号56219-10-4 顺-9-十六碳烯酸乙酯 | CAS号57-10-3 棕榈酸 | CAS号106-73-0 庚酸甲酯

合成工艺路线路线简述

    8-溴辛酸乙酯置于sodium Phosphinate,水,Sodium Hexamethyldisilazane,Sodium Hydroxide体系中,用 四氢呋喃 用作溶剂,化学反应 25.0H,反应生成棕榈油酸
    参考文献:Synthesis And Characterization Of Novel Acyl-Glycine Inhibitors Of Glyt2
    标题:Synthesis And Characterization Of Novel Acyl-Glycine Inhibitors Of Glyt2
    摘要:It Has Been Demonstrated Previously That The Endogenous Compound N-Arachidonyl-Glycine Inhibits The Glycine Transporter Glyt2,Stimulates Glycinergic Neurotransmission,And Provides Analgesia In Animal Models Of Neuropathic And Inflammatory Pain. However,It Is A Relatively Weak Inhibitor With An Ic50,Of 9 Mu M And Is Subject To Oxidation Via Cyclooxygenase,Limiting Its Therapeutic Value. In This Paper We Describe The Synthesis And Testing Of A Novel Series Of Monounsaturated C18 And C16 Acyl-Glycine Molecules As Inhibitors Of The Glycine Transporter Giyt2. We Demonstrate That They Are Up To 28 Fold More Potent That N-Arachidonyl-Glycine With No Activity At The Closely Related Glyt1 Transporter At Concentrations Up To 30 Mu M. This Novel Class Of Compounds Show Considerable Promise As A First Generation Of Giyt2 Transport Inhibitors.
    Doi:10.1021/acschemneuro.7B00105

    海关参考信息

    专利信息


    专利号:EP-1309698-B1
    优先权日:2000-07-21
    标 题:A cytochrome p450 enzyme associated with the synthesis of delta-12 -epoxy groups in fatty acids of plants
    发明人:CAHOON EDGAR B
    权利人:DU PONT
    摘要:An isolated nucleic acid fragment encoding a cytochrome P450 enzyme associated with the synthesis of plant DELTA12-epoxy fatty acids is disclosed. The invention also relates to making a chimeric construct encoding all or a portion of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids, in sense or antisense orientation, wherein expression of the chimeric construct results in production of altered levels of the cytochrome P450 enzymes associated with the synthesis of plant DELTA12-epoxy fatty acids in a transformed host cell.

    专利号:WO-2018020240-A1
    优先权日:2016-07-27
    标 题:Process for the synthesis of semiconductor nanocrystals
    发明人:HOU BO; CHA SEUNGNAM
    权利人:UNIV OXFORD INNOVATION LTD
    摘要:The invention relates to a process for the synthesis of semiconductor nanocrystals, comprising mixing a nonaqueous solution of a metal precursor with a solid-state chalcogen and reacting the resulting mixture at a temperature of about 90 °C or greater. In another aspect the invention relates to the use of a solid chalcogen in the heterogeneous synthesis of metal chalcogenide semiconductor nanocrystals. Semiconductor nanocrystals obtainable by the processes of the invention are further provided. In particular, nanocrystalline PbS or PbSe having a band gap of greater than 1.6 eV and/or a photoluminescence emission wavelength of about 440 to about 515 nm, and nanocrystalline ZnS or ZnSe having a photoluminescence emission wavelength of about 410 to about 430 nm, and solar cells comprising such nanocrystals, are provided.

    专利号:US-8569560-B2
    优先权日:2006-10-13
    标题 :Synthesis of terminal alkenes from internal alkenes via olefin metathesis
    发明人:SCHRODI YANN; PEDERSON RICHARD L; KAIDO HIROKI; TUPY MICHAEL J
    权利人:ELEVANCE RENEWABLE SCIENCES
    摘要:This disclosure relates generally to olefin metathesis, and more particularly relates to the synthesis of terminal alkenes from internal alkenes using a cross-metathesis reaction catalyzed by an olefin metathesis catalyst. According to one aspect, for example, a method is provided for synthesizing a terminal olefin, the method comprising contacting, in the presence of a ruthenium alkylidene metathesis catalyst, an olefinic substrate comprised of at least one internal olefin with a cross metathesis partner comprised of an alpha olefinic reactant, under reaction conditions effective to allow cross-metathesis to occur, wherein the reaction conditions include a reaction temperature of at least 35° C. The methods, compositions, reactions and reaction systems herein disclosed have utility in the fields of catalysis, organic synthesis, and industrial chemistry.

    专利号:US-9643915-B2
    优先权日:2013-03-15
    标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
    发明人:ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
    权利人:CERENIS THERAPEUTICS HOLDING SA
    摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

    专利号:US-9708354-B2
    优先权日:2013-03-15
    标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
    发明人:ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
    权利人:CERENIS THERAPEUTICS HOLDING SA
    摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

    专利号:US-2014194584-A1
    优先权日:2013-01-07
    标题 :Process for the synthesis of w-Unsaturated nitrile-acid/ester in which two types of cross metathesis are alternated consecutively swing process
    发明人:DUBOIS JEAN-LUC; COUTURIER JEAN-LUC
    权利人:ARKEMA FRANCE
    摘要:The invention relates to a process for the synthesis of a monounsaturated nitrile-ester (acid) by cross metathesis starting from an unsaturated compound I comprising at least one trivalent nitrile, acid or ester functional group, characterized in that it comprises a stage in which two types of cross metathesis are alternated consecutively:n a first type of cross metathesis cm1 with an acrylic compound II chosen from acrylonitrile, acrylic acid or an acrylic ester, one of the compounds I or II comprising a nitrile functional group and the other of these compounds II or I comprising an acid or ester functional group, and a second type of cross metathesis cm2 with a light C 2 to C 4 alkene compound III, preferably with ethylene. nn The invention also relates to a process for the synthesis of an α,ω-amino ester (acid) obtained by a process comprising a stage in which the two types of cross metathesis defined above are alternated consecutively, followed by a hydrogenation stage.
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    主要参考文献


    1: Chen L, Xiang H, Yang H, Zhang J, Huang B, Tan Z, Wang Y, Ma H. Inhibition of porcine origin Klebsiella pneumoniae capsular polysaccharide and immune escape by BY3 compounded traditional Chinese medicine residue fermentation broth. Microb Pathog. 2024 Aug
    13:106853. doi: 10.1016/j.micpath.2024.106853. Epub ahead of print.
    12:1394126. doi: 10.3389/fchem.2024.1394126.

    合成参考文献


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    摘要:Watanabe T, Tsuda S, Nishimura H, Honda Y, Watanabe T. Characterization of a Delta12-fatty acid desaturase gene from Ceriporiopsis subvermispora, a selective lignin-degrading fungus. Appl Microbiol Biotechnol. 2010 Jun;87(1):215–24. doi: 10.1007/s00253-010-2438-1.
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    摘要:Oh D, Lee Y, La B, Yeo J, Chung E, Kim Y, Lee C. Fatty acid composition of beef is associated with exonic nucleotide variants of the gene encoding FASN. Molecular Biology Reports. 2011 Jul 20;39(4):4083–90. doi: 10.1007/s11033-011-1190-7.
    参考文献:10.1186/1476-511x-10-120
    摘要:Yang Z, Miyahara H, Hatanaka A. Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes. Lipids in Health and Disease. 2011 Jul 21;10(1):120. doi: 10.1186/1476-511x-10-120.
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