CAS: 35975-00-9; 6-Nitroquinolin-5-Amine

相似化合物

14204-97-8 98589-84-5 42143-23-7

上下游产品

CAS号613-50-3 6-硝基喹啉 | CAS号100-01-6 对硝基苯胺 | CAS号82050-10-0 2-氨基-3-(三氘代甲基)-... | CAS号76180-96-6 2-氨基-3-甲基-3H-咪唑... | CAS号102408-25-3 2-氨基-1-甲基-3H-咪唑... | CAS号88328-40-9 6-nitro-5-pyrro... | CAS号42143-23-7 5,6-喹啉二胺

📜6-硝基喹啉置于potassium Tert-Butylate,1,1,1-三甲基碘化肼体系中,用 二甲基亚砜 作为反应溶剂,化学反应 1.0H,以95%的收率获得产物5-氨基-6-硝基喹啉
参考文献:1,1,1-三甲基碘化碘对硝基喹啉的取代亲核胺化
标题:1,1,1-三甲基碘化碘对硝基喹啉的取代亲核胺化
摘要:在存在t-Buok的dmso中,通过1,1,1-三甲基碘化氢碘(tmhi)通过氢(vns)的取代核亲核取代(vns)进行了3-,5-,6-,7-和8-硝基喹啉的胺化反应.研究过.胺化以区域选择性地产生相对于硝基的邻,邻,邻和对和对异构体,产率高(95-86%).2-硝基喹啉不进行取代胺化,但是不稳定的硝基被氨基取代,然后转化为亚胺化合物并水解得到2(1H)-喹啉酮.
DOI:10.1002/jhet.5570450652

专利信息

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:US-5656634-A
优先权日:1991-03-21
标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
发明人：CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J
权利人:PFIZER
摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

专利号:US-2004167329-A1
优先权日:2003-02-21
标 题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process