CAS: 35061-50-8; N-((2R,3R,4R,5S,6R)-5-(((2S,3R,4R,5S,6R)-3-Acetamido-4,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-2,4-Dihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3-yl)Acetamide

该化合物是一种分解物,一种是蛋白的衍生物,在甲壳类和昆虫的外壳质中发现,一种天然聚合物,其特征是白色和脱白晶状表面,由于存在氢氧基和乙酰功能组,在水中可以溶解.N,N-欧元二乙基乙酰胺在生物化学和分子生物学中,特别是在与甘基蛋白和聚沙酸盐有关的研究中发挥重要作用.该产品还涉及制药和生物技术领域,可能用于其潜在的生物前期效应,并用作各种酶反应的基质.该化合物的结构允许其参与各种生物过程,包括细胞信号和免疫反应.其化学数据库和监管环境中的化学文摘社编号为35061-50-8,用于识别.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号1398-61-4 甲壳素

合成工艺路线路线简述

    Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于甲醇,氨体系中,化学反应生成 N,N'-二乙酰基壳二糖
    参考文献:Crystallized N,N'-Diacetylchitobiose1
    标题:Crystallized N,N'-Diacetylchitobiose1
    摘要:
    DOI:10.1021/ja01610A070

    海关参考信息

    专利信息


    专利号:WO-2023008461-A1
    优先权日:2021-07-27
    标题:Medicament for treatment and/or prevention of cancer
    发明人:KUME MASAHIKO; OKANO FUMIYOSHI; SAITO TAKANORI
    权利人:TORAY INDUSTRIES
    摘要:The present invention relates to a medicament for the treatment and/or prevention of cancer, the medicament being characterized by comprising an antibody having an immunological reactivity with CAPRIN-1 protein or a fragment of the antibody and a drug capable of inhibiting the N-glycoside-linked sugar chain synthesis of a glycoprotein which are combined with each other in a blended or separated form.

    专利号:US-9850473-B2
    优先权日:2011-03-03
    标 题:Transglycosylation activity of glycosynthase mutants of an endo-beta-N-acetylglucosaminidase (endo-D) from Streptococcus pneumoniae
    发明人:WANG LAI-XI
    权利人:UNIV MARYLAND
    摘要:The present invention provides for recombinant Endo-D and selected mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor by transglycosylation. Such recombinant Endo-D and selected mutants are useful for efficient glycosylation remodeling of IgG1-Fc domain.

    专利号:US-6271442-B1
    优先权日:1990-12-20
    标 题 :Method of producing pathogen-resistant plants
    发明人:SCHELL JEFF; LOGEMANN JUERGEN; JACH GUIDO; MUNDY JOHN
    权利人:MAX PLANCK GESELLSCHAFT
    摘要:Described are a method of producing pathogen-resistant plants in which a protein-synthesis inhibitor gene or a fusion product of the protein-synthesis inhibitor gene or of the protein-synthesis inhibitor protein with ligands permitting specific attachment to cells is introduced into the genotype of plants under the control of an active promotor, and the use of the protein-synthesis inhibitor protein obtained by introducing the protein-synthesis inhibitor gene into the bacterial overproducers for making pharmaceutical preparations.

    专利号:US-10851174-B2
    优先权日:2011-03-03
    标 题:Core fucosylated glycopeptides and glycoproteins: chemoenzymatic synthesis and uses thereof
    发明人:WANG LAI-XI; HUANG WEI; GIDDENS JOHN
    权利人:WANG Lai Xi; HUANG WEI; GIDDENS JOHN; UNIV MARYLAND
    摘要:A chemoenzymatic method for the preparation of a core-fucoslyated glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of a fucosylated GlcNAc-protein and fucosylated GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of an endoglycosidase (ENGase) selected from Endo;F1, Endo-F2, Endo-F3, Endo-D and related glycosynthase mutants to transfer the oligosaccharide moiety to the acceptor and yield the structure defined core-fucosylated glycoprotein or glycopeptide. The donor substrate includes, in a specific implementation, a synthetic oligosaccharide oxazoline. A related method of fucosylated glycoprotein or fucosylated glycopeptide remodeling with a predetermined natural N-glycan or a tailor-made oligosaccharide moiety, and a method of remodeling an antibody to include a predetermined sugar chain to replace a heterogeneous sugar chain, are also described.

    专利号:US-2024287564-A1
    优先权日:2021-06-07
    标题 :Acholetin biopolymers and methods for enzymatic synthesis
    发明人:WITHERS STEPHEN G; MACDONALD SPENCER S S
    权利人:UNIV BRITISH COLUMBIA
    摘要:Provided herein are β-1,3-linked biopolymers (acholetin polysaccharides). Furthermore, provided herein are enzymatic methods and systems for producing β-1,3-linked oligosaccharides and polysaccharides using β-1,3-N-acetylglucosaminide phosphorylase (Acholetin phosphorylase (AchP)). The AchP was sourced from the genome of the cell wall-less Mollicute bacterium, Acholeplasma laidlawii and was found to synthesize β-1,3-linked N-acetylglucosamine (GlcNAc) or N-acetylgalactosamine (GalNAc) oligomers using the donor. α-N-acetylglucosamine 1-phosphate (GlcNAc1-P) or N-acetylgalactosamine 1-phosphate (GalNAc1-P).

    专利号:US-2023011163-A1
    优先权日:2020-05-09
    标题:Synthesis of human milk oligosaccharides by a Beta-N-acetylhexosaminidase from Haloferula sp.
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    合成参考文献


    参考文献:10.1080/09168451.2020.1805584
    摘要:Ohno M, Miyazaki M, Kimura M, Minowa Y, Sakaguchi M, Oyama F, Yamashita T. Characterization of mouse di-N-acetylchitobiase that can degrade chitin-oligosaccharides. Biosci Biotechnol Biochem. 2020 Dec;84(12):2499–507. doi: 10.1080/09168451.2020.1805584.
    参考文献:10.1074/jbc.m310614200
    摘要:Hiruma T, Togayachi A, Okamura K, Sato T, Kikuchi N, Kwon YD, Nakamura A, Fujimura K, Gotoh M, Tachibana K, Ishizuka Y, Noce T, Nakanishi H, Narimatsu H. A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAc. J Biol Chem. 2004 Apr 02;279(14):14087–95. doi: 10.1074/jbc.m310614200.
    参考文献:10.1007/s00438-002-0640-2
    摘要:Xiao X, Wang F, Saito A, Majka J, Schlösser A, Schrempf H. The novel Streptomyces olivaceoviridis ABC transporter Ngc mediates uptake of N-acetylglucosamine and N,N'-diacetylchitobiose. Molecular Genetics and Genomics. 2002 Apr 09;267(4):429–39. doi: 10.1007/s00438-002-0640-2.
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