CAS: 31251-41-9; 8-Chloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-B]Pyridin-11-One

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4-氯-2-溴甲基-1-碘-苯置于正丁基锂,甲基叔丁基醚,Sodium Hydride,Lithium Diisopropyl Amide体系中,用 四氢呋喃,环己烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 1.42H,反应生成 8-氯-5,6-二氢-11H-苯并[5,6]环庚烷并[1,2-B]吡啶-11-酮
参考文献:An Anion-Induced Regio-And Chemoselective Acylation And Its Application To The Synthesis Of An Anticancer Agent
标题:An Anion-Induced Regio-And Chemoselective Acylation And Its Application To The Synthesis Of An Anticancer Agent
摘要:[graphics]An Efficient Grignard-And Organolithium-Induced Regio-And Chemoselective Anionic Acylation Is Reported. A Number Of Tricyclic Ketones Are Prepared In Good To Excellent Yields Via This Method. This Method Is Complementary To The Frieldel-Crafts Acylation For Elect Ron-Deficient Substrates. A Novel Anisole-Based Grignard Reagent Was Developed To Effect The Cyclization Of Sterically Hindered Substrates. This Novel Reagent Has Been Successfully Applied To The Synthesis Of Sch 66336,A Candidate For Oncologic Treatment.
DOI:10.1021/ol016809D

专利信息

专利号:US-6608202-B1
优先权日:2001-08-21
标题:Process of synthesis of a tricyclic ketone intermediate
发明人：DORAN HENRY J; O'NEILL PAT M; WILLIAMS ROBERT P
权利人:SCHERING CORP
摘要:In one embodiment, the present invention describes the synthesis of a compound of Formula III, wherein X is halogen,and intermediates therefor from easily available starting materials by a simple route.

专利号:US-6495689-B2
优先权日:1998-11-20
标题 :Synthesis of intermediates useful in preparing tricyclic compounds
发明人：BERNARD CHARLES F; CASEY MICHAEL; CHEN FRANK XING; GROGAN DENISE C; POIRIER MARC; WILLIAMS ROBERT P; WONG YEE-SHING; WU GEORGE G
权利人:SCHERING CORP
摘要:Disclosed is a process for preparing a compound having the formula:wherein R, R1, R2, R3, and R4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy.

专利号:US-2003144314-A1
优先权日:2001-08-21
标 题 :Process of synthesis of a tricyclic ketone intermediate

专利号:US-2002077331-A1
优先权日:1998-11-20
标 题:Synthesis of intermediates useful in preparing tricyclic compounds

专利号:US-2003050319-A1
优先权日:2000-04-18
标题:Synthesis of intermediates useful in preparing tricyclic compounds

专利号:EP-1421068-B1
优先权日:2001-08-21
标题:A process of synthesis of a tricyclic ketone intermediate