CAS: 299-20-7; Etamycin
该化合物是属于被称为宏观融化物的化合物类的抗生素,主要来自某些链球菌的发酵,Etamycin表现出抗菌特性,特别是针对一系列抗菌性细菌,有助于治疗各种感染,该化合物的特征是其大型乳腺环结构,这是大型的大型大型大型长效,含有多种功能组,有助于其生物活动.Etamycin通过抑制细菌蛋白合成,从而防止细菌的生长和繁殖.必须指出,与其它抗生素一样,使用催生素应该以易感测试为指导,以避免产生抗药性.此外,潜在的副作用可能包括胃肠紊乱和过敏反应,在治疗期间应该加以监测.
- 英文名称Etamycin
- 中文名称宜他霉素A
- IUPAC名称3-hydroxy-N-[(3R,6S,7R,10S,13S,16S,22R,24R)-24-hydroxy-7,11,13,17,20-pentamethyl-16-[(2S)-3-methylbutan-2-yl]-3-(2-methylpropyl)-2,5,9,12,15,18,21-heptaoxo-10-phenyl-8-oxa-1,4,11,14,17,20-hexazabicyclo[20.3.0]pentacosan-6-yl]pyridine-2-carboxamide
- 其它别名Etamycin(7CI); Viridogrisein (6CI); 1H-Pyrrolo[2,1-o][1,4,7,10,13,16,19]oxahexaazacyclod°Cosine, cyclic peptidederiv.; Glycine,N-[N-[N-[N-[cis-4-hydroxy-1-[N-[N-[(3-hydroxy-2-pyridinyl)carbonyl]-L-threonyl]-D-leucyl]-D-prolyl]-N-methylglycyl]-N,4-dimethyl-L-isoleucyl]-L-alanyl]-N-methyl-L-2-phenyl-,u-lactone; N-[N-[N-[N-[cis-4-Hydroxy-1-[N-[N-[(3-hydroxy-2-pyridinyl)carbonyl]-L-threonyl]-D-leucyl]-D-prolyl]-N-methylglycyl]-N,4-dimethyl-L-isoleucyl]-L-alanyl]-N-methyl-L-2-phenylglycineu-lactone; Neoviridogrisein IV; Viridogrisein I
- CAS编号299-20-7
- MFCD编号:MFCD01939588
- FDA UNII编号:PAF72P8T3G
- 分子式:C44H62N8O11分子量:879.01
- 产品CID: 1281424
- 产品分类有机原料 → 有机酸及其衍生物 → 肽模拟物
物理性质
- 熔点168-170 °C (分解)
- 沸点1213.8±65.0 °C(预测)
- 密度1.31±0.1 g/cm3(预测)
- PH:D26 +62°, +31° (c = 5 in chloroform, alc)
- pKa:pKa about 1 to 2(at 25°C)
- 外观形态白色无定形固体
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是一种抗生素物质(氨溶酯内酯),由STREPSTOCEPICES GRISEUS和联合的STREPETOMICES生产,活跃于抗抗克抗阳性米昆菌菌肺结核和一些真菌及其他"阴囊"感染.
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海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2909110000-乙醚
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- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-5662898-A
优先权日:1990-08-20
标 题 :Genes for the synthesis of antipathogenic substances
发明人：LIGON JAMES M; HILL DWIGHT STEVEN; LAM STEPHEN TING; HAMMER PHILIP E
权利人:CIBA GEIGY CORP
摘要:The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.
专利号:US-5817502-A
优先权日:1994-06-08
标题 :Genes for the synthesis of pyrrolnitrin
专利号:EP-0635577-B1
优先权日:1993-07-23
标 题 :Screen for inhibitors of melanin biosynthesis
发明人：BRINDLE FRANCES HARRIET ELIZAB; FROELIGER EUNICE HARRIET
权利人:BASF AG
摘要:A method for the identification of agents that inhibit melanin biosynthesis involves the incubation of test samples in cultures of a fungus that produces melanin. Observation of altered pigmentation in the culture or culture area containing test sample indicates inhibition of melanin biosynthesis. Preferred cultures for the screen contain a fungus that pigments in the light or the dark such as Cladosporium cucumerinum. Preferred embodiments employ test samples on disks or in wells in solidified cultures and a known melanin synthesis inhibitor as a positive control which is compared to the test sample by simple visual inspection.
专利号:US-5639949-A
优先权日:1990-08-20
标 题 :Genes for the synthesis of antipathogenic substances
专利号:WO-9533818-A2
优先权日:1994-06-08
标 题:Genes for the synthesis of antipathogenic substances
专利号:US-5698425-A
优先权日:1990-08-20
标 题:Method of protecting plants by transformation with genes for the synthesis of antipathogenic substances
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Schinke C, Martins T, Queiroz SCN, Melo IS, Reyes FGR. Antibacterial Compounds from Marine Bacteria, 2010-2015. J Nat Prod. 2017 Apr 28;80(4):1215-1228. doi: 10.1021/acs.jnatprod.6b00235. Epub 2017 Mar 31. Review. pii: E1495. doi: 10.3390/molecules24081495.
4: Haste NM, Perera VR, Maloney KN, Tran DN, Jensen P, Fenical W, Nizet V, Hensler ME. Activity of the streptogramin antibiotic etamycin against methicillin-resistant Staphylococcus aureus. J Antibiot (Tokyo). 2010 May;63(5):219-24. doi: 10.1038/ja.2010.22. Epub 2010 Mar 26.
5: Sun P, Maloney KN, Nam SJ, Haste NM, Raju R, Aalbersberg W, Jensen PR, Nizet V, Hensler ME, Fenical W. Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp. Bioorg Med Chem. 2011 Nov 15;19(22):6557-62. doi: 10.1016/j.bmc.2011.06.053. Epub 2011 Jun 26.
合成参考文献
参考文献:10.1016/j.bmc.2011.06.053
摘要:Sun P, Maloney KN, Nam S, Haste NM, Raju R, Aalbersberg W, Jensen PR, Nizet V, Hensler ME, Fenical W. Fijimycins A–C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp. Bioorganic & Medicinal Chemistry. 2011 Nov;19(22):6557–62. doi: 10.1016/j.bmc.2011.06.053.
参考文献:10.1002/pmic.201000697
摘要:Mohimani H, Yang YL, Liu WT, Hsieh PW, Dorrestein PC, Pevzner PA. Sequencing cyclic peptides by multistage mass spectrometry. Proteomics. 2011 Sep;11(18):3642–50.
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