CAS: 27652-89-7; (4-Chlorophenyl)(Pyridin-2-yl)Methanol

上下游产品

CAS号1121-60-4 吡啶-2-甲醛 | CAS号106-39-8 对氯溴苯 | CAS号1018349-32-0 2-[(4-chlorophe... | CAS号873-77-8 4-氯苯基溴化镁 | CAS号110-86-1 吡啶 | CAS号104-88-1 对氯苯甲醛 | CAS号108-90-7 氯苯 | CAS号98-98-6 2-吡啶甲酸 | CAS号6318-51-0 (4-氯苯基)(2-吡啶基)甲酮 | CAS号4350-41-8 2-对氯苄基吡啶 | CAS号486-16-8 卡比沙明 | CAS号207726-35-0 4-((4-氯苯基)(吡啶-2... | CAS号6318-51-0 (4-氯苯基)(2-吡啶基)甲酮 | CAS号122368-54-1 2-[(4-氯苯基)(4-哌啶... | CAS号142404-69-1 2-[氯(4-氯苯基)甲基]吡啶 | CAS号78539-93-2 [1,2,3]Triazolo...

2-氰基吡啶置于二苯基亚砜,9-Methyl-10,13-Diphenyl-9H-Dibenzo[a,C]Carbazole,四丁基氟化铵体系中,用 四氢呋喃,乙腈 用作溶剂,化学反应 48.0H,反应生成α-(4-氯苯基)吡啶-2-甲醇
参考文献:由非 D-A 型超级有机还原剂和亚砜或硫化物 Hat 试剂实现的含 O,S 或 N 化合物的 α-C(Sp3)-H 2-吡啶基化合成羧甲胺
标题:由非 D-A 型超级有机还原剂和亚砜或硫化物 Hat 试剂实现的含 O,S 或 N 化合物的 α-C(Sp3)-H 2-吡啶基化合成羧甲胺
摘要:叔胺 (R 3 N) 的自由基阳离子已被公认为 Hat 试剂在光化学转化中的前体.同样,带有 Sh 基团的硫醇和硫代酸也被广泛用作 Hat 试剂.尽管亚砜(r 2So) 和硫化物 (Rsr) 也带有孤对电子,这些化合物几乎没有被报道为光催化中的 Hat 试剂.另一方面,已经记录了含 O 或 N 化合物的 α-C-H 4-吡啶基化,而 2-吡啶基化仍然具有挑战性.然而,抗组胺药和抗胆碱药羧甲胺是一种带有2-吡啶基的醚,目前还没有通过醚的α-光芳基化得到.在这项工作中,我们报告了非供体-受体 (D-A) 型有机光还原剂 Cbz6和亚砜/硫化物协同催化醚,硫醚和胺的一般 α-C(Sp 3 )-H 芳基化的发现.通过使用低至 1 Mol% 的cbz6作为可回收的有机光还原剂和作为新型hat试剂的亚砜或硫化物,已经完成了含o,N或s的化合物的2-或4-吡啶基化.这是含 O,N 或 S 化合物的 α-C-h
Doi:10.1039/d2Sc03504A

专利信息

专利号:US-10865390-B2
优先权日:2018-02-12
标 题 :Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols
发明人：NI YE; ZHOU JIEYU; XU GUOCHAO; WANG YUE
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.

专利号:US-10822593-B2
优先权日:2018-02-12
标 题:Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols
发明人：NI YE; ZHOU JIEYU; XU GUOCHAO; WANG YUE
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.

专利号:US-11078465-B2
优先权日:2018-02-12
标题:Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols
发明人：NI YE; WANG YUE; DAI WEI; XU GUOCHAO; ZHOU JIEYU
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.

专利号:US-6417363-B1
优先权日:1997-12-04
标题 :Heterocyclyl ligand containing ruthenium and osmium catalysts
发明人：VAN DER SCHAAF PAUL ADRIAAN; MUEHLEBACH ANDREAS; HAFNER ANDREAS; KOLLY ROMAN
权利人:CIBA SC HOLDING AG
摘要:Penta- and hexa-coordinated, bridged ruthenium and osmium catalysts of the formulawherein Me is ruthenium or osmium; L1 and L2 are neutral ligands having electron donor properties;X is an anionic ligand; Y is oxygen or sulphur; A is a direct bond, C1-C4alkylene or C2-C4alkylidene;Z is a direct bond, oxygen, sulphur or the groupswherein R1 and R2 are hydrogen or hydrocarbon radicals; their preparation and their us in the synthesis of polymers, in the ring-closure metathesis of diolefins, in the cross metathesis of olefins and in the isomerisation of olefins are disclosed.

专利号:US-2019345456-A1
优先权日:2018-02-12
标 题:Alcohol Dehydrogenase Mutant and Application thereof in Synthesis of Diaryl Chiral Alcohols

专利号:WO-2019153634-A1
优先权日:2018-02-12
标题 :Alcohol dehydrogenase mutant and application thereof in synthesis of biaryl chiral alcohol