专利号:US-4629784-A 优先权日:1983-08-16 标 题:Synthesis of cyclopropane amino acids 发明人:STAMMER CHARLES H 权利人:UNIV GEORGIA RES FOUND 摘要:Cyclopropane ('Cyclopropyl') amino acids and peptides containing at least one cyclopropyl amino acid are disclosed. The processes for synthesizing cyclopropyl amino acids and peptides containing at least one cyclopropyl amino acid are also disclosed. Cyclopropyl amino acids are useful as enzyme inhibitors and as substitutes for natural amino acids in peptide hormones such as regulators of bodily functions to enhance bioactivity, to stabilize the peptide into which it is incorporated to cleavage by enzymes and to convert such peptides into enzyme inhibitors.
专利号:US-4301065-A 优先权日:1977-05-25 标 题 :Novel polypeptides having thymic activity or an antagonistic activity and processes for their synthesis 发明人:BACH JEAN-FRANCOIS; DARDENNE MIREILLE; PLEAU JEAN-MARIE; HAMBURGER JEAN; BRICAS EVANGHELOS; MARTINEZ JEAN; BLANOT DIDIER; AUGER GENEVIEVE 权利人:ANVAR 摘要:The invention is concerned with novel polypeptides and processes for the synthesis thereof. It is concerned with compounds having the sequence X-Gln-Gly-Gly-Y in which Y represents -Ser-Asn and X represents Ser-, Lys-Ser-, Ala-Lys-Ser-, Glx-Ala-Lys-Ser-; Glx representing Pyro-Glu or Gln; and when X represents Glx-Ala-Lys-Ser-, Y may in addition represent -Ser; as well as their derivatives comprising one or two modified amino acids, with the exception of the unmodified compound PyroGlu-Ala-Lys-Ser-Gln-Gly-Ser-Asn. These polypeptides are useful as medicines.
专利号:US-4416817-A 优先权日:1979-06-08 标题:3-Methoxy-2-oxoazetidine derivatives and their production 发明人:MATSUO TAISUKE; OCHIAI MICHIHIKO 权利人:TAKEDA CHEMICAL INDUSTRIES LTD 摘要:Novel 3-methoxy-2-oxoazetidine derivatives, which are shown by the following formula wherein R1 is amino, acylated amino or protected amino, are of value as intermediates for the synthesis of useful compounds represented by the formula wherein R1 has the same meaning as defined above, as drugs in the treatment of bacterial infections.
专利号:RU-2098409-C1 优先权日:1992-02-13 标 题 :Method of synthesis of (s)-(-)- and (r)-(+)-isomers of (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido-[3,4-b]-pyrazine- -7-yl)-carbamide acid ethyl ester or their pharmaceutically acceptable salts and intermediate (s)-(-)- and (r)-(+)-isomers of [6-amino-4-[[2-(alkoxyalkylamino)-1-methyl-2-oxoethyl]-ami- -no]-5-nitro-2-pyridinyl]-carbamide acid ethyl ester
专利号:CN-102686601-A 优先权日:2009-11-16 标 题 :Synthesis of Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2
专利号:WO-2011060355-A1 优先权日:2009-11-16 标题 :Process for the synthesis of ac-arg-cyclo(cys-d-ala-his-d-phe-arg-trp-cys)-nh2