CAS: 25697-55-6; (3-(Trifluoromethyl)Phenyl)Methanethiol

上下游产品

2-(3-Trifluoromethyl-benzyl)-isothiourea 3-Trifluoromethylbenzyl chloride 1-[(4-chlorobutyl)thiomethyl]-3-trifluoromethylbenzene 4-(2-fluorophenyl)-1,2,3,6-tetrahydro-1-methylpyridine 4-(2-Fluoro-phenyl)-1-methyl-4-(3-trifluoromethyl-benzylsulfanyl)-piperidine hexakis-(3-trifluoromethylbenzylthiomethyl)benzene

📜1-氯甲基-3-三氟甲基苯置于sodium Hydroxide体系中,用 乙醇 用作溶剂,化学反应 3.33H,反应生成3-三氟甲基苄硫醇
参考文献:反式(+-)-N-甲基-2-(3-吡啶基)-2-四氢硫代吡喃碳硫酰胺1-氧化物(rp 49356)及其类似物的合成和生物活性:一类新型的钾通道开放剂.
标题:反式(+-)-N-甲基-2-(3-吡啶基)-2-四氢硫代吡喃碳硫酰胺1-氧化物(rp 49356)及其类似物的合成和生物活性:一类新型的钾通道开放剂.
摘要:报道了反式-(+-)-N-甲基-2-(3-吡啶基)-2-四氢硫代吡喃氨基甲磺酰胺+++ E 1-氧化物(8A,Rp 49356)和类似物的合成和生物活性.这些化合物构成k(+)通道开放剂的新结构类.讨论了吡啶基,硫代酰胺和硫杂环上的变化对体外k(+)通道开放反应性的影响.为了活性,优选3-吡啶基或3-喹啉基,小的n-烷基硫代酰胺官能团和氧化亚砜环,其中亚砜与硫代酰胺具有反式关系.选择的化合物在降压麻醉的大鼠中静脉内测试降压作用,其活性反映了其体外k(+)通道的开放活性.
Doi:10.1021/jm00098A004

专利信息

专利号:US-7186709-B2
优先权日:2002-08-27
标 题:Dihydropyrancarboxamides and uses thereof
发明人：SCHREIBER STUART L; STAVENGER ROBERT A; MITCHISON TIMOTHY J; MALIGA ZOLTAN
权利人:HARVARD COLLEGE
摘要:The present invention provides novel dihydropyrancarboxamide compounds of formula (I): n nand collections of these compounds, and provides methods for the synthesis of these compounds; wherein R 1 –R 6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.

专利号:US-6797819-B1
优先权日:1998-06-11
标 题 :Alkaloids
发明人：SHAIR MATTHEW; WESTWOOD NICHOLAS; PELISH HENRY EFREM; KIRCHHAUSEN THOMAS; FENG YAN
权利人:HARVARD COLLEGE; CBR INST FOR BIOMED RES INC
摘要:The present invention provides novel alkaloid compounds and collections of these compounds, and provides methods for the synthesis of these compounds using biomimetic synthetic strategies. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as bacterial infections, proliferative diseases, and reproductive disorders, to name a few.