CAS: 2550-36-9; (Bromomethyl)Cyclohexane

相似化合物

35541-75-4 57702-84-8 1647-26-3

上下游产品

cyclohexylmethyl alcohol bicyclo[4.1.0]heptane 1,1-Dibromomethylcyclohexane (Bromoiodomethyl)cyclohexane3-(2-cyclohexylethyl)pyridine N-(cyclohexylmethyl)-N-ethylamine N,N-dimethylcyclohexylmethylamine N,N-diethyl-cyclohexylmethylamine

环己基甲基4-甲基苯磺酸盐置于15-冠醚-5,Sodium Bromide体系中,用90.3%的收率获得溴甲基环己烷
参考文献:一种环己基溴甲烷的制备方法
标题:一种环己基溴甲烷的制备方法
摘要:本发明涉及一种环己基溴甲烷的制备方法,其步骤如下:(1),在有机溶剂中加入碱与环己甲醇,再滴加式(i)化合物,进行酯化得到有机相中间体滤液;式(i)化合物如下,其中:R为c1~12烷基,C1~12卤代烷基,C3~8环烷基,苯基,苄基或芳烃;X为卤素原子;环己甲醇与式(i)化合物的摩尔比为1:1~1:2;(2),在上述制得的有机相中间体滤液中加入溴化物和冠醚类催化剂进行溴化反应得反应液,再经过滤除去废盐和精馏得到粗品环己基溴甲烷,再进行干燥,得到成品环己基溴甲烷.本发明具有能减少高盐废水的产生,并且缩短反应时间,提高反应速率,减低生产成本,提高产品收率的优点.

专利信息

专利号:WO-2011106929-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO
权利人:MERCK SHARP & DOHME; ANGELETTI P IST RICHERCHE BIO; MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO
摘要:Compounds of formula I that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infection and for inhibiting HCV viral replication and /or viral production in a cell-based system.

专利号:US-5856497-A
优先权日:1995-12-11
标题 :Asymmetric synthesis of α-cycloalkylalkyl substituted methanamines
发明人：ROTH GREGORY; LANDI JOHN
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:This invention relates to process for asymmetrically producing enantiomerically pure α-cycloalkylalkyl substitututed methanamines from α-pinene. One key step of the process of this invention utilizes the oxidation product of α-pinene, hydroxy pinanone, as a chiral auxiliary to direct the stereoselective alkylation of the corresponding ketimine. This invention also relates to key intermediates useful in the processes referred to herein.

专利号:US-5834606-A
优先权日:1995-06-14
标 题 :Synthesis of conduritol epoxides and aziridines and methods of using such to synthesize higher disaccharides
发明人：HUDLICKY TOMAS
权利人:GENENCOR INT; VIRGINIA TECH INTELL PROP
摘要:There are described novel coupling reactions useful for the preparation of cyclitol and/or carbohydrate conjugates and carbocyclic analogs thereof. Such coupling reactions employ epoxides and/or aziridines described herein as electrophilic recipients of other cyclitol or carbohydrate units. Also provided are certain novel compounds.

专利号:US-2012328569-A1
优先权日:2010-03-02
标题:Inhibitors of hepatitis c virus ns5b polymerase
发明人：MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN
权利人:MCCOMAS CASEY CAMERON; LIVERTON NIGEL J; SOLL RICHARD; LI PENG; PENG XUANJIA; WU HAO; NARJES FRANK; HABERMANN JOERG; KOCH UWE; LIU SHILAN
摘要:Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-3674750-A
优先权日:1971-01-14
标题:Quarternary phosphonium salt catalyzed synthesis of urethanes and polyurethanes
发明人：BRADY DONNIE G
权利人:PHILLIPS PETROLEUM CO
摘要:A process for producing urethanes by reacting an alkyl halide and an alkali metal cyanate in the presence of an organo hydroxy compound employing a phosphonium salt as a catalyst in which process the isolation of the intermediate isocyanate is unnecessary.

专利号:EP-0765336-B1
优先权日:1994-06-17
标 题 :Synthesis of conduritol epoxides and aziridines and methods of using such to synthesize higher disaccharides
发明人：HUDLICKY TOMAS
权利人:VIRGINIA TECH INTELL PROP
摘要:There are described novel coupling reactions useful for the preparation of cyclitol and/or carbohydrate conjugates and carbocyclic analogs thereof. Such coupling reactions employ epoxides and/or aziridines described herein as electrophilic recipients of other cyclitol or carbohydrate units. Also provided are certain novel compounds.