CAS: 24484-93-3; Methyl 4-Chloropicolinate

相似化合物

5470-22-4 63071-10-3 63071-13-6

上下游产品

methanol 4-chloro-pyridine-2-carbonyl chloride 2-Picolinic acid 1-oxy-pyridine-2-carboxylic acid methyl ester4-chloro-pyridine-2-carboxylic acid hydrazide 4-morpholin-4-yl-pyridine-2-carboxylic acid N-phenyl-4-chloro-2-pyridinecarboxamide methyl 4-phenylpyridine-2-carboylate

2-吡啶甲酸置于氯化亚砜体系中,用 N,N-二甲基甲酰胺,甲苯 用作溶剂,化学反应 48.0H,反应生成4-氯吡啶-2-甲酸甲酯
参考文献:通过改变芳香族供体基团的碱度来调节过渡金属联吡啶的配合物的性质
标题:通过改变芳香族供体基团的碱度来调节过渡金属联吡啶的配合物的性质
摘要:联吡啶(3,7-二氮杂双环[3.3.1]壬烷)是非常刚性和高度组织化的配体,在配位化学领域得到广泛应用,它们的过渡金属配合物的氧化还原电势在高氧氧化反应中很重要.价铁络合物,铜络合物催化的叠氮化和64 Cu铜正电子发射断层显像剂成像.在这里,我们显示了15个四齿联吡啶的铜(II)配合物的氧化还原电势和稳定性常数可以通过取代吡啶环来改变(氧化还原电势在约450 Mv以上的变化和复合物稳定性在约10 Mv以上的变化)日志单位).还表明,这些变化可以通过p K A预测.吡啶基团的值以及取代基的哈米特参数,以及基于密度泛函理论的能量分解分析,还可以使人们准确地预测氧化还原电势和随之而来的配合物稳定性.结果表明,主要贡献来自于静电相互作用能,因此吡啶供体基团的部分电荷也与氧化还原电势相关.
Doi:10.1021/ic4004214

专利信息

专利号:US-12378246-B2
优先权日:2019-04-11
标 题:Synthetic options towards the manufacture of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl} - 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one
发明人：CUNIERE NICOLAS; FAN YU; KOLOTUCHIN SERGEI; MUKHERJEE SUBHA; SIMMONS ERIC M; SINGH AMARJIT; WEI CAROLYN S; XIAO YI; YUAN CHANGXIA; ZHENG BIN; WAGSCHAL SIMON ALBERT; BROGGINI DIEGO FERNANDO DOMENICO; CAO DUY CHI TRUNG; CHERNICHENKO KOSTIANTYN; LEMAIRE SEBASTIEN FRANCOIS EMMANUEL; BEN HAÃ?M CYRIL
权利人:BRISTOL MYERS SQUIBB CO; JANSSEN PHARMACEUTICA NV
摘要:Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

专利号:US-2025115629-A1
优先权日:2021-03-18
标 题 :Chiral synthons for the synthesis of chiral phosphorothioates
发明人：ZHANG YONGDA; WU LINGLIN
权利人:BOEHRINGER INGELHEIM INT
摘要:This invention relates to compounds of Formula (I) useful as synthons for a general synthetic method for making chiral phosphorothioates, to their preparation and to their use in a robust large scale process for making P-chiral phosphorothioates.

专利号:WO-2022194924-A1
优先权日:2021-03-18
标 题:Chiral synthons for the synthesis of chiral phosphorothioates

专利号:EP-4308580-A1
优先权日:2021-03-18
标 题:Chiral synthons for the synthesis of chiral phosphorothioates

专利号:US-8372971-B2
优先权日:2004-08-25
标 题:Heterocyclic compounds and methods of use
发明人：WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
权利人:TARGEGEN INC; WRASIDLO WOLFGANG; DNEPROVSKAIA ELENA
摘要:Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

专利号:CN-116981677-A
优先权日:2021-03-18
标 题:Chiral synthons for the synthesis of chiral phosphorothioates