CAS: 2375815-63-5; 5-(5-((1S,2R)-2-Isopropylcyclopropyl)-6-Methylpyridazin-3-yl)Pyrimidine-2,4(1H,3H)-Dione

• 英文名称5-(5-((1S,2R)-2-Isopropylcyclopropyl)-6-Methylpyridazin-3-yl)Pyrimidine-2,4(1H,3H)-Dione
• 中文名称5-(5-((1S,2R)-2-异丙基环丙基)-6-甲基哒嗪-3-基)嘧啶-2,4(1H,3H)-二酮
• IUPAC名称5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione
• 其它别名5-(5-((1S,2R)-2-Isopropylcyclopropyl)-6-Methylpyridazin-3-yl)Pyrimidine-2,4(1H,3H)-Dione; 5-[6-Methyl-5-[(1S,2R)-2-Propan-2-Ylcyclopropyl]Pyridazin-3-Yl]-1H-Pyrimidine-2,4-Dione; Inhibitor,Cancer,Cd73 In 3,Cd-73-In-3,Cd73In3,Cd73,Immunosuppression,Tumor,Inhibit; 5-[5-[(1S,2R)-2-Isopropylcyclopropyl]-6-Methyl-Pyridazin-3-Yl]-1H-Pyrimidine-2,4-Dione; Cd73-In-3; Cd73-In-3, 10 Mm In Dmso
• CAS编号2375815-63-5
• MFCD编号:MFCD01123336
• 分子式:C15H18N4O2分子量:286.33
• 产品CID: 1180360
• 产品分类Chemistry → Heterocyclic Building Blocks → Aromatic Heterocycles

• 相似结构搜索
• InChIKey: WHRUIISQCORGKK-KOLCDFICSA-N
• InChI=1S/C15H18N4O2/c1-7(2)9-4-11(9)10-5-13(19-18-8(10)3)12-6-16-15(21)17-14(12)20/h5-7,9,11H,4H2,1-3H3,(H2,16,17,20,21)/t9-,11+/m1/s1
• 计算化学: 氢键受体数4.0氢键供体数2.0可旋转键数3.0

物理性质

• 密度1.245±0.06 g/cm3(预测)
• pKa:7.25±0.10(预测)
• LogP:1
• 溶解性DMSO: 100 mg/mL (349.25 Mm; Need Ultrasonic)
• 外观形态白色至类白色固体
• 储存条件储存在 -20°C
• 产品应用该化合物是具有威力且选择性的CD73 INHIBBITOR,与IC50, 28 NM. LY347507, 单独或与PEMBROCROIZUMAB合并的IC50一起,目前正在接受高级癌症患者的试验.

MSDS等安全信息

• 警示词Warning
• 危险描述H315-H319-
• 防范说明P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-

合成工艺路线路线简述

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管