CAS: 2094-72-6; 1-Adamantanecarbonyl Chloride

相似化合物

2094-74-8 1660-04-4 21816-08-0

上下游产品

CAS号828-51-3 1-金刚烷甲酸 | CAS号768-90-1 1-溴金刚烷 | CAS号4411-25-0 异氰酸1-金刚烷酯 | CAS号5511-18-2 1-金刚烷甲酰胺 | CAS号4942-47-6 1-金刚烷乙酸 | CAS号17768-41-1 1-金刚烷甲胺 | CAS号5122-82-7 1-金刚烷基溴甲酮 | CAS号18341-84-9 1-(1-adamantyl)... | CAS号2094-73-7 金刚烷-1-甲酸乙酯 | CAS号1660-05-5 1-(1-adamantyl)... | CAS号78679-70-6 (1-adamantanyl)... | CAS号768-95-6 1-金刚烷醇

1-金刚烷甲酸置于吡啶,草酰氯体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 4.0H,反应生成金刚烷酰氯
参考文献:通过酰亚胺的 N-C 裂解协同可见光光氧化还原/镍催化合成脂肪族酮
标题:通过酰亚胺的 N-C 裂解协同可见光光氧化还原/镍催化合成脂肪族酮
摘要:开发了一种用于合成脂肪酮的亲电,酰亚胺基,可见光促进的光氧化还原/镍催化交叉偶联反应.该协议通过 N-C(O) 键激活进行,由于吸电子基团使氮上的孤对电子离域,金属插入该键的激活能较低,从而使金属插入该键成为可能.交叉偶联反应操作简单且温和,在环境温度下进行,并且对多种官能团表现出耐受性.
Doi:10.1021/acs.Orglett.7B00989

专利信息

专利号:US-12012427-B2
优先权日:2019-10-31
标 题 :Synthesis of Fmoc-protected morpholino monomers and their use in the synthesis of morpholino oligomer
发明人：SINHA SURAJIT; KUNDU JAYANTA; GHOSH UJJWAL
权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE
摘要:Present invention relates to stable Fmoc protected Morpholino monomers and corresponding oligonucleotides (PMO) and efficient synthesis of the same involving chlorophosphoramidate and H-Phosphonate chemistry. Successful syntheses of the oligonucleotide with higher yield and lesser time have been accomplished employing solid phase synthesis and easy deprotection of Fmoc group with Piperidine.

专利号:US-11926589-B2
优先权日:2019-07-09
标 题 :Process for the synthesis of non-racemic cyclohexenes
发明人：REISMAN SARAH; ROMBOLA MICHAEL; LADD CAROLYN L; MCLAUGHLIN MARTIN JOHN; ZUEND STEPHAN; GOETZ ROLAND
权利人:BASF CORP; CALIFORNIA INST OF TECHN
摘要:This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation M m+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R 10a , R 10b , R 10c , R 10d , R 10a′ , R 10b′ , R 10c′ , R 10d′ , Z and Z′ have the meanings as defined in the description.

专利号:US-6048975-A
优先权日:1991-09-12
标 题:Process for the chemical synthesis of oligonucleotides
发明人：PFLEIDERER WOLFGANG; BERGMANN FRANK
权利人:HOECHST AG
摘要:A process for the chemical synthesis of oligonucleotides n Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. n The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make oligonucleotide synthesis possible with high yields in very small quantities.

专利号:US-5945524-A
优先权日:1990-09-14
标 题 :Process for the chemical synthesis of oligonucleotides
发明人：PFLEIDERER WOLFGANG; BERGMANN FRANK
权利人:HOECHST AG
摘要:Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. n The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make oligonucleotide synthesis possible with high yields in very small quantities.

专利号:US-2006154256-A1
优先权日:2001-10-25
标 题:Method for covalently attaching nucleosides and/or nucleotides on surfaces and method for determining coupling yields in the synthesis of nucleotides
发明人：STENGELE KLAUS-PETER; KVASSIOUK EVGUENI
权利人:STENGELE KLAUS-PETER; KVASSIOUK EVGUENI
摘要:The present invention relates to a method for covalently attaching nucleosides and/or nucleotides on surfaces having reactive functional groups, where in a first step, the reactive functional groups are made to react with suitable derivatized nucleosides and/or nucleotides, and in a second step, they are converted with a protecting group reagent, so that a reaction product of the consecutive reaction interacts with electromagnetic radiation such that it can be quantitatively determined. The invention also relates to a method for determining the repetitive coupling yields in the synthesis of nucleotides where the free 3′ or 5′ hydroxy group of a selected nucleoside and/or nucleotide is converted with a compound of formula (I) n n nwhere L is a common suitable leaving group, the motif O—PX represents a phosphor amidite, a H-phosphonate a phosphonic acid ester, a phosphotriester, Yâ•?O or S, N is a nucleoside or a nucleotide derivative which subsequently reacts further with a protecting group reagent and the elimination of the leaving group (L), which is subsequently further eliminated. The quantity of the leaving group (L) eliminated in step b) is quantitatively determined in the form of its anion (L − ) by means of otical spectroscopy.

专利号:US-11655255-B2
优先权日:2022-10-17
标题 :Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein
发明人：ZHANG WANBIN; WANG MO; ZHANG LU; HUO XIAOHONG; ZHANG ZHENFENG; YUAN QIANJIA; CHEN JIANZHONG
权利人:SPH NO 1 BIOCHEMICAL & PHARMACEUTICAL CO LTD; UNIV SHANGHAI JIAOTONG
摘要:A method for catalytic asymmetric synthesis of a phosphorus-stereogenic (P-stereogenic) nucleoside derivative of formula (3) and a catalyst used therein. The P-stereogenic nucleoside derivative (3) can be hydrolyzed to obtain remdesivir. Specifically, a nucleoside and phosphoryl chloride are subjected to asymmetric reaction under the catalysis of a chiral bicyclic imidazole catalyst in the presence of a base to produce the P-stereogenic nucleoside derivative of formula (3)