CAS: 112245-09-7; (R)-2-Amino-3,3-Dimethylbutan-1-Ol

相似化合物

112245-13-3 3907-02-6 153645-26-2

上下游产品

methyl (R)-2-amino-3,3-dimethylbutanoate L-tert-butylglycine methyl ester hydr°Chloride sodium 3,3-dimethyl-2-oxobutyrate (R)-1-(benzyloxymethyl)-2,2-dimethylpropylamine (S)-1,2,2-trimethylpropylamine (R)-2-{[(S)-1-(Diphenyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3,3-dimethyl-butyric acid (R)-2-{[(S)-1-(Di-o-tolyl-phosphinothioyl)-pyrrolidine-2-carbonyl]-amino}-3,3-dimethyl-butyric acid (R)-2-({(S)-1-[Bis-(2-ethyl-phenyl)-phosphinothioyl]-pyrrolidine-2-carbonyl}-amino)-3,3-dimethyl-butyric acid

(Rs,1R)-2-Methylpropane-2-Sulfinic Acid [1-((Tert-Butyldimethylsilanyloxy)Methyl)-2,2-Dimethylpropyl]Amide置于盐酸体系中,用 1,4-二氧六环,甲醇 用作溶剂,化学反应 0.5H,以87%的收率获得(R)-(-)-叔-亮氨酸醇
参考文献:使用叔丁烷亚磺酰基醛亚胺和酮亚胺的不对称合成受保护的1,2-氨基醇.
标题:使用叔丁烷亚磺酰基醛亚胺和酮亚胺的不对称合成受保护的1,2-氨基醇.
摘要:带有α-苄氧基或α-甲硅烷氧基取代基的叔丁烷亚磺酰基醛亚胺和酮亚胺以高收率和非对映选择性用作合成被保护的1,2-氨基醇的前体.描述了将非支链烷基,支链烷基和芳基有机金属试剂添加到n-亚磺酰基醛亚胺1和2以及酮亚胺5和6中的一般规程.此外,亚氨基酰胺产物3,4,7的选择性n-或o-脱保护描述了图8和8,使得能够进一步合成反应产物.
Doi:10.1021/jo0156868

专利信息

专利号:WO-2024121335-A1
优先权日:2022-12-07
标题:Synthesis of sulfoximine compounds having a stereogenic sulfur atom
发明人：WILLIAMS SIMON; SMITS HELMARS
权利人:SYNGENTA CROP PROTECTION AG
摘要:A process for the preparation of compound of formula (I) which process comprises: (A) stereoselectively oxidizing a sulfanyl compound of formula (II) followed by (B) stereospecific imination of a sulfinyl compound of formula (III) is disclosed wherein the substituents are as defined in claim 1.

专利号:WO-2016202806-A1
优先权日:2015-06-15
标题:A novel synthetic pathway towards apremilast
发明人：STAVBER GAJ
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to a process for providing a chiral β-hydroxysulfone compound, an intermediate useful in the synthesis of the isoindoline-based compound apremilast.

专利号:EP-4630421-A1
优先权日:2022-12-07
标 题:Synthesis of sulfoximine compounds having a stereogenic sulfur atom

专利号:WO-9931506-A1
优先权日:1997-12-18
标题 :Parallel solution phase synthesis of lactams

专利号:US-8450342-B2
优先权日:2007-09-12
标题:Perharidines as CDK inhibitors
发明人：MEIJER LAURENT; BETTAYEB KARIMA; GALONS HERVE; DEMANGE LUC; OUMATA NASSIMA
权利人:MEIJER LAURENT; BETTAYEB KARIMA; GALONS HERVE; DEMANGE LUC; OUMATA NASSIMA; CENTRE NAT RECH SCIENT; UNIV RENNES; UNIV PARIS DESCARTES
摘要:The invention relates to trisubstituted or tetrasubstituted imidazo[4,5b]pyridines, to their uses as well as to a process for manufacturing them. n The compounds of the invention are imidazo[4,5b]pyridines. n The first general synthesis of 3,5,7 imidazo[4,5b]pyridines is disclosed in the description. n The invention founds application, in particular, in the pharmaceutical field.