CAS: 1121-07-9; 1-Methylpyrrolidine-2,5-Dione

该化合物是一种来自氨基酸的环状浸渍物,其特点是取代氮原子上的一组甲基物质,该化合物通常用作有机合成的中间体,特别是在生产药品,农用化学品和特殊化学品方面,其硬性循环结构和极性有助于其在凝聚和替代反应中的再活性.N-甲基氨基氨基氨基酸在极地有机溶剂中表现出良好的溶解性,有利于其在各种合成用途中的使用.该化合物在标准条件下的稳定性和定义明确的再活性特征使其成为研究人员和工业化学家的可靠再试剂,他们试图将基于氨基植物的分子纳入目标分子.

结构式图片

相似化合物

2142-06-5 38018-27-8 10478-33-8

欧盟法规

ECHA物质C&L通报

上下游产品

diazomethane Succinimide methanol 1-phenyl-3-methyltriazene5-(4-bromo-phenyl)-5-hydroxy-1-methyl-pyrrolidin-2-one 5-Hydroxy-1-methyl-5-phenylpyrrolidin-2-one 1-methyl-2,5-diphenyl-pyrrole phenacylacetophenone

合成工艺路线路线简述

  • 合成目标产物 N-Methylsuccinimide 主要起始原料 Succinic Anhydride And Methylamine Hydrochloride
  • 132407-76-2 = 1121-07-9 + 791-28-6
    反应条件:1.1 Reagents: Oxygen Solvents: N-Methyl-2-Pyrrolidone
    标题:Regenerable N-Alkylamide Hydroperoxide For Catalytic Substrate Oxidation
    作者:Patton,Douglas E.; Drago,Russell S.
    参考文献:Journal Of The Chemical Society 日期:1993 卷标:(14) 页码:1611-15]

    65039-03-4 + 98837-98-0 + 110-15-6 = 1121-07-9 + 106-65-0 + 123-25-1 + 2314-78-5 + 627-73-6 + 925-93-9
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Carbon Dioxide,1-Ethyl-3-Methylimidazolium Bis(Trifluoromethylsulfonyl)Imide; 160 Bar,Rt -> 150 °C; 18 H,150 °C
    标题:Valuable New Platform Chemicals Obtained By Valorisation Of A Model Succinic Acid And Bio-Succinic Acid With An Ionic Liquid And High-Pressure Carbon Dioxide
    作者:Silva,Daniel; Bogel-Lukasik,Ewa
    参考文献:Green Chemistry 日期:2017 卷标:19(17) 页码:4048-4060
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成N-甲基丁二酰胺
参考文献:Menschutkin,Justus Liebigs Annalen Der Chemie,1876,Vol. 182,P. 92
标题:Menschutkin,Justus Liebigs Annalen Der Chemie,1876,Vol. 182,P. 92

海关参考信息

专利信息


专利号:US-9090560-B2
优先权日:2013-09-04
标 题 :Process for microwave assisted synthesis of N-methyl pyrrolidone
发明人:KHATRI PRAVEEN KUMAR; JAIN SUMAN LATA; CHATERJEE ALOK KUMAR; BIR SAIN
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a process for microwave assisted synthesis of N-methyl pyrrolidone (NMP). Particularly the process relates to the synthesis of N-methyl succinimide or corresponding analogs by using microwave irradiation which on hydrogenation in the presence of a hydrogenating catalyst gives N-methyl pyrrolidone. Compared to the conventional heating microwave process requires less energy inputs and reduces the reaction time drastically from 5-6 h to 2-5 min.

专利号:US-7429658-B2
优先权日:2003-09-11
标题 :Synthesis of protected pyrrolobenzodiazepines
发明人:HOWARD PHILIP; MASTERSON LUKE
权利人:SPIROGEN LTD
摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):

专利号:US-7557099-B2
优先权日:2004-03-01
标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines
发明人:HOWARD PHILIP WILSON; KANG GYOUNG-DONG
权利人:SPIROGEN LTD
摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.

专利号:EP-1473330-B1
优先权日:1996-07-17
标题:Process for the synthesis of oxonol compound
发明人:NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which each of Z, W<1> and W<2> independently is an atomic group that forms a heterocyclic ring; and M is a cation. A process for the synthesis of an oxonol compound is disclosed.

专利号:US-9006425-B2
优先权日:2009-03-18
标题:Aluminum complexes and their use in the synthesis of cyclic carbonates
发明人:NORTH MICHAEL
权利人:NORTH MICHAEL; UNIV YORK
摘要:Dimeric aluminum catalysts of formula I: and their use in catalyzing the synthesis of cyclic carbonates from epoxides and carbon dioxide.

专利号:US-9604911-B2
优先权日:2013-12-05
标题 :Process for the synthesis of agomelatine
发明人:BRIERE JEAN-FRANÇOIS; LEBEUF RAPHAËL; LEVACHER VINCENT; HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I):

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Ohgi Takahashi, Et Al. Modeling The Enolization Of Succinimide Derivatives, A Key Step Of Racemization Of Aspartic Acid Residues: Importance Of A Two-H2O Mechanism. Chem Biodivers. 2010 Jun;7(6):1349-56.

合成参考文献


摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2018) 3, 59.
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