合成目标产物 N-Methylsuccinimide 主要起始原料 Succinic Anhydride And Methylamine Hydrochloride
132407-76-2 = 1121-07-9 + 791-28-6 反应条件:1.1 Reagents: Oxygen Solvents: N-Methyl-2-Pyrrolidone 标题:Regenerable N-Alkylamide Hydroperoxide For Catalytic Substrate Oxidation 作者:Patton,Douglas E.; Drago,Russell S. 参考文献:Journal Of The Chemical Society 日期:1993 卷标:(14) 页码:1611-15]
65039-03-4 + 98837-98-0 + 110-15-6 = 1121-07-9 + 106-65-0 + 123-25-1 + 2314-78-5 + 627-73-6 + 925-93-9 反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Carbon Dioxide,1-Ethyl-3-Methylimidazolium Bis(Trifluoromethylsulfonyl)Imide; 160 Bar,Rt -> 150 °C; 18 H,150 °C 标题:Valuable New Platform Chemicals Obtained By Valorisation Of A Model Succinic Acid And Bio-Succinic Acid With An Ionic Liquid And High-Pressure Carbon Dioxide 作者:Silva,Daniel; Bogel-Lukasik,Ewa 参考文献:Green Chemistry 日期:2017 卷标:19(17) 页码:4048-4060
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成N-甲基丁二酰胺 参考文献:Menschutkin,Justus Liebigs Annalen Der Chemie,1876,Vol. 182,P. 92 标题:Menschutkin,Justus Liebigs Annalen Der Chemie,1876,Vol. 182,P. 92
专利号:US-9090560-B2 优先权日:2013-09-04 标 题 :Process for microwave assisted synthesis of N-methyl pyrrolidone 发明人:KHATRI PRAVEEN KUMAR; JAIN SUMAN LATA; CHATERJEE ALOK KUMAR; BIR SAIN 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to a process for microwave assisted synthesis of N-methyl pyrrolidone (NMP). Particularly the process relates to the synthesis of N-methyl succinimide or corresponding analogs by using microwave irradiation which on hydrogenation in the presence of a hydrogenating catalyst gives N-methyl pyrrolidone. Compared to the conventional heating microwave process requires less energy inputs and reduces the reaction time drastically from 5-6 h to 2-5 min.
专利号:US-7429658-B2 优先权日:2003-09-11 标题 :Synthesis of protected pyrrolobenzodiazepines 发明人:HOWARD PHILIP; MASTERSON LUKE 权利人:SPIROGEN LTD 摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):
专利号:US-7557099-B2 优先权日:2004-03-01 标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines 发明人:HOWARD PHILIP WILSON; KANG GYOUNG-DONG 权利人:SPIROGEN LTD 摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.
专利号:EP-1473330-B1 优先权日:1996-07-17 标题:Process for the synthesis of oxonol compound 发明人:NISHIGAKI JUNJI; DEGUCHI YASUAKI 权利人:FUJI PHOTO FILM CO LTD 摘要:An oxonol compound is represented by the following formula (I): in which each of Z, W<1> and W<2> independently is an atomic group that forms a heterocyclic ring; and M is a cation. A process for the synthesis of an oxonol compound is disclosed.
专利号:US-9006425-B2 优先权日:2009-03-18 标题:Aluminum complexes and their use in the synthesis of cyclic carbonates 发明人:NORTH MICHAEL 权利人:NORTH MICHAEL; UNIV YORK 摘要:Dimeric aluminum catalysts of formula I: and their use in catalyzing the synthesis of cyclic carbonates from epoxides and carbon dioxide.
专利号:US-9604911-B2 优先权日:2013-12-05 标题 :Process for the synthesis of agomelatine 发明人:BRIERE JEAN-FRANÇOIS; LEBEUF RAPHAËL; LEVACHER VINCENT; HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE 权利人:SERVIER LAB 摘要:Process for the industrial synthesis of the compound of formula (I):
[参考文献]: Ohgi Takahashi, Et Al. Modeling The Enolization Of Succinimide Derivatives, A Key Step Of Racemization Of Aspartic Acid Residues: Importance Of A Two-H2O Mechanism. Chem Biodivers. 2010 Jun;7(6):1349-56.
合成参考文献
摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2018) 3, 59.