CAS: 111969-64-3; (1R,2S,5R)-2-Isopropyl-5-Methylcyclohexyl 2,2-Dihydroxyacetate

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上下游产品

CAS号2216-51-5 (-)-薄荷醇 | CAS号81529-62-6 (1R,2S,5R)-2-is... | CAS号26315-61-7 乙醛酸薄荷酯 | CAS号147027-09-6 (2R,5R)-(1R,2S,... | CAS号147027-10-9 5-(4-氨基-2-氧代-2H... | CAS号147126-62-3 (2R,5R)-5-羟基-1,...

(1R)-(-)-薄荷基乙醛酸置于聚合甲醛,水,Sodium Hydrogensulfite体系中,用 环己烷,水 用作溶剂,化学反应 12.0H,反应生成L-䓝基乙醛酸酯水合物
参考文献:一种减少恩曲他滨中间体mgh合成过程杂质 的方法
标题:一种减少恩曲他滨中间体mgh合成过程杂质 的方法
摘要:本发明公开了一种减少恩曲他滨中间体mgh合成过程杂质的方法,包括如下步骤:以l‑薄荷醇和乙醛酸为原料,经酸催化下进行酯化反应,然后在亚硫酸氢钠作用下进行加成反应,然后甲醛作用下进行羟基化反应,后处理得到的二羟基乙酸l‑薄荷酯;所述加成反应过程中,Ph值为4‑6,反应温度为40‑80°C,反应时间为4‑10小时.本发明大大降低了反应时间,缩短了反应周期,同时反应过程中仅采用环己烷作为有机溶剂,操作简单,后处理方便,而且通过对工艺条件和后处理条件的控制,大大降低了杂质含量,提高了收率.同时,本发明为恩曲他滨的注册申报,生产中控以及提高恩曲他滨中间体的质量标准提供一定的帮助.

专利信息

专利号:US-6329522-B1
优先权日:1994-04-23
标题:Process for the diastereoselective synthesis of nucleoside analogues
发明人：HILL MALCOLM LEITHEAD; WHITEHEAD ANDREW JONATHAN; HORNBY ROY; HALLETT PETER; GOODYEAR MICHAEL DAVID; DWYER P OWEN
权利人:GLAXO GROUP LTD
摘要:The invention relates to a diastereoselective process for the preparation of compounds of formula (1), wherein W is S, S=O, SO2 or O; X is S, S=O, SO2 or O; R1 is hydrogen or acyl, and R2 is a purine or pyrimidine base or an analogue or derivative thereof.

专利号:US-6051709-A
优先权日:1994-04-23
标 题 :Process for the diastereoselective synthesis of nucleoside analogues

专利号:CN-1500782-A
优先权日:1994-04-23
标 题 :Process for the diastereoselective synthesis of nucleoside analogues

专利号:AP-704-A
优先权日:1994-04-23
标题 :Process for the diastereoselective synthesis of nucleoside analogues.

专利号:US-10815223-B2
优先权日:2016-06-14
标 题:Process for producing Lamivudine and Emtricitabine
发明人：MANDALA DEVENDER; WATTS PAUL
权利人:UNIV NELSON MANDELA METROPOLITAN
摘要:This invention provides for flow and batch synthesis processes for the production of Lamivudine and Emtricitabine, including flow and batch synthesis processes wherein at least of the synthesis steps are conducted in a solvent free environment.