CAS: 109273-98-5; (S)-(1S,3R,7S,8S,8Ar)-3,7-Dimethyl-8-(2-((R)-6-Oxo-3,6-Dihydro-2H-Pyran-2-yl)Ethyl)-1,2,3,7,8,8A-Hexahydronaphthalen-1-Yl 2-Methylbutanoate
该化合物是一种从真菌发酵中产生的自然生成的恒星,是合成胆固醇低效药物的关键中间体.在结构上,它具有一种混凝土的狄纳系统,增强了其进一步化学改造的活性.该化合物因其在受控条件下溶性提高和稳定性,在生产Simvastatin等半合成性凝固素方面的作用而备受重视.其高纯度和定义明确的化学特性使其适合用于心血管药物开发的研究和工业应用.脱水液态液态素通常在不高的条件下处理,以保持其完整性.
- 英文名称(S)-(1S,3R,7S,8S,8Ar)-3,7-Dimethyl-8-(2-((R)-6-Oxo-3,6-Dihydro-2H-Pyran-2-yl)Ethyl)-1,2,3,7,8,8A-Hexahydronaphthalen-1-Yl 2-Methylbutanoate
- 中文名称去羟基洛伐他汀
- IUPAC名称(1S,3R,7S,8S,8aR)-3,7-dimethyl-8-(2-((R)-6-oxo-3,6-dihydro-2H-pyran-2-yl)ethyl)-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate
- 其它别名Lovastatin Ep Impurity C; Lovastatin Ep Impurity C (Dehydro Lovastatin); [(1S,3R,7S,8S,8Ar)-3,7-Dimethyl-8-[2-[(2R)-6-Oxo-2,3-Dihydropyran-2-Yl]Ethyl]-1,2,3,7,8,8A-Hexahydronaphthalen-1-Yl] (2S)-2-Methylbutanoate; (S)-(1S,3R,7S,8S,8Ar)-3,7-Dimethyl-8; 2',3'-Anhydromonacolin K; Alpha,Beta-Dehydrolovastatin; Dehydromonacolin K
- CAS编号109273-98-5
- MFCD编号:MFCD18382246
- EINECS号:641-622-8
- FDA UNII编号:2BW5MV3UB3
- 分子式:C24H34O4分子量:386.53
- 产品CID: 128844
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号75330-75-5 洛伐他汀合成工艺路线路线简述
📜洛伐他汀置于甲基磺酰氯,三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 1.0H,以100%的收率获得alpha,Beta-去氢洛伐他汀
参考文献:土曲霉突变体对环状九环的转化阻止了lova和lovc基因的洛伐他汀生物合成.
标题:土曲霉突变体对环状九环的转化阻止了lova和lovc基因的洛伐他汀生物合成.
摘要:检查了具有lovc或lova基因被破坏的两个曲霉曲霉突变体的能力,这些突变体可将九肽转化为洛伐他汀1(一种降胆固醇药物).Lovc破坏剂能够有效地将二氢莫纳可林l 5或莫纳可林j 9转化为1,还可以将去甲基莫纳可林j 15转化为紧致蛋白3.相反,Lova突变体具有意想不到的活性β-氧化系统,仅产生少量的1在加入直接前体9后,大部分添加的非核苷酸都降解为庚肽22.类似地,Lova突变体不会积聚聚酮化合物合酶产物5,并通过两个β-氧化和β-环化反应迅速降解了作为前体添加的任何5.在c-6处羟基化得到20.
Doi:10.1039/b207721C
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2901241000-1,3-丁二烯
2905122000-异丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Cytotoxic Dehydromonacolins From Red Yeast Rice作者:Lin Zhu,Lee-Fong Yau,Jing-Guang Lu,Guo-Yuan Zhu,Jing-Rong Wang,Quan-Bin Han,Wen-Luan Hsiao,Zhi-Hong Jiang |发布日期:2012.2.1
摘要:Two New Dehydromonacolins (1 And 3), Together With Nine Known Monacolins (4-12), Were Isolated From Red Yeast Rice. Compounds 4-6 Were Isolated From A Natural Resource For The First Time. Their Structures Were Elucidated By Means Of Nmr And Mass Spectroscopic Analyses. The Structure Of Dehydromonacolin N (1) Was Further Confirmed By Its Semisynthesis From Monacolin K (Lovastatin) (11). Dehydromonacolin J (2), An Intermediate In The Semisynthesis Of 1, Was Obtained As A New Dehydromonacolin. The Structure Of Dehydromonacolin L (3) Was Also Confirmed By An Elimination Reaction Of Monacolin L (12). Compound 1, Possessing A C2 Side Chain, Is Unprecedented In The Natural Monacolin Family And Exhibited Moderate Cytotoxic Activity Against Hep G2, Caco-2, And Mcf-7 Cancer Cell Lines. Dehydromonacolin K (8) Demonstrated The Most Potent Cytotoxicity To All Three Of These Cell Lines. The Structure Activity Relationship Of Natural And Synthesized Monacolins Was Discussed. This Is The First Report On The Cytotoxic Effects Of Dehydromonacolins.
合成参考文献
参考文献:10.1021/jf000338c
摘要:Ma J, Li Y, Ye Q, Li J, Hua Y, Ju D, Zhang D, Cooper R, Chang M. Constituents of red yeast rice, a traditional Chinese food and medicine. J Agric Food Chem. 2000 Nov;48(11):5220–5. doi: 10.1021/jf000338c.
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