CAS: 10224-18-7; 2,2-Bis(4-Isocyanatophenyl)Hexafluoropropane

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2,2-bis(4-aminophenyl)hexafluoropropane

📜2,2-双(4-氨基苯基)六氟丙烷 以 5,5-Dimethyl-1,3-Cyclohexadiene,丙酮 用作溶剂,20.0~140.0 °C,101.33 Kpa 条件下,反应 6.0H,反应生成2,2-双(4-异氰酸苯基)六氟丙烷
参考文献:一种使用胺与碳酰氟制备异氰酸酯的方法
标题:一种使用胺与碳酰氟制备异氰酸酯的方法
摘要:本发明公开了一种使用碳酰氟直接与胺反应制备相应异氰酸酯的高效合成法.该方法主要包括以下两步:(1)胺与碳酰氟以优选的配比,在密闭环境,适宜反应条件下,无水惰性有机溶剂中发生酰基化反应生成中间体氨基甲酰氟;(2)常压时,适宜反应条件下,中间体氨基甲酰氟脱氟化氢得到目标异氰酸酯.反应过程无需添加催化剂,反应条件温和,反应过程中过量的碳酰氟及使用过的溶剂高效回收套用,副产物hf收集精制后可以商品化销售.

专利信息

专利号:US-7674876-B2
优先权日:2005-05-25
标题:Synthesis of novel monomers containing the trifluorovinylidene group and the cyanato group and polymers thereof
发明人：DREYER CHRISTIAN; BAUER MONIKA; IYER SURESH S; SMITH DENNIS W
权利人:FRAUNHOFER GES FORSCHUNG; UNIV CLEMSON
摘要:Novel hybrid monomers containing both the aryltrifluorovyinyloxyether-group (TFVE-group) and the cyanato-group, their synthesis, and the synthesis of polymers made from these new hybrid monomers are disclosed.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:CN-108358794-A
优先权日:2018-02-02
标题:A new method for the synthesis of 2,2-bis(4-aminophenyl)hexafluoropropane

专利号:CN-108358794-B
优先权日:2018-02-02
标题 :Synthesis method of 2, 2-bis (4-aminophenyl) hexafluoropropane