CAS: 95153-31-4; (2S,3As,7As)-1-[(2S)-2-[[(1S)-1-Carboxybutyl]Amino]Propanoyl]-2,3,3A,4,5,6,7,7A-Octahydroindole-2-Carboxylic Acid

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CAS号107133-36-8 培哚普利

📜培哚普利叔丁胺盐置于水,氢氯噻嗪体系中,化学反应 120.0H,反应生成 培哚普利
参考文献:Impact Of Hydrochlorothiazide On The Stability Of Two Perindopril Salts. Evaluation Of The Interaction With HPLC And Esi Lc/ms Methods
标题:Impact Of Hydrochlorothiazide On The Stability Of Two Perindopril Salts. Evaluation Of The Interaction With HPLC And Esi Lc/ms Methods
摘要:Perindopril (Per) Belongs To The Group Of The Angiotensin-Converting Enzyme Inhibitors And Is Widely Prescribed Antihypertensive Drug. It Can Be Used In Monotherapy Or In Combination Therapy For Example With Hydrochlorothiazide (Hth). As On The Market There Is No Pharmaceutical Formulation Containing Both Drugs And In Literature Has Not Been Reported Any Work About Effect Of Hth On Per Degradation Process,The Primary Objective Of This Study Was The Assessment Of Stability Of Two Salts Of Perindopril N Tert-Butylamine (Pert) And Arginine (Pera) In A Mixtures Model With Hth In Different Relative Humidities And Constant Temperature. The Objective Of The Study Was Establishing The Mechanisms Of Drug Decomposition In The Presence Of Hth. Results Were Achieved Using The High-Performance Liquid Chromatography (Rp-HPLC). The Degradation Rate Constants For Mixtures And Pure Substances Were Calculated. Decomposition Products Have Been Analyzed By Esi Lc/ms And The Decomposition Mechanism For Each Salt Has Been Proposed. The Degradation Of Pert In The Presence Of Hth Took Place According To Autocatalytic Reaction Kinetic Mechanism,Described Mathematically By Prouttompkins Equation,And The Decomposition Process Leads To Hydrolysis. Hth In The Model Mixture With Pera Generates A First-Order Kinetic Model Of The Decomposition Reaction,And There Are Two Main Products Of Decomposition: Product Of Hydrolysis And Diketopiperazine. Our Study Showed That Hth Has Statistically Significant Positive Impact On Both Salts. It Can Be Suggested That Pert Or Pera And Hth Can Be Formulated Together,Hence There Is No Negative Interaction Between The Drugs.
DOI:10.32383/appdr/82922

专利信息

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:EP-1679072-B9
优先权日:2005-01-06
标 题:Process for for synthesis of (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indole-2- carboxylic acid derivatives and use in the synthesis of perindopril
发明人：KUMAR ASHOK; SOUDAGAR SATISH RAJANIKANT; MATHUR ARPANA; GUNJAL SANJAY TUKARAM; PANDA NALINAKSHYA BALARAM; JADHAV DILIP UTTAM
权利人:IPCA LAB LTD
摘要:The present invention relates to a novel salts of Perindopril, namely: perindopril phthalic acid salt; perindopril tartaric acid salt; perindopril phosphate; perindopril camphor sulphonate; perindopril oxalate; perindopril citrate; perindopril-(-)-di-p-toluoyl tartarate; perindopril (+)-di- p- toluoyl tartarate; and perindopril (±)-dibenzoyltartarate.

专利号:EP-1679072-A1
优先权日:2005-01-06
标题 :Process for for synthesis of (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indole-2- carboxylic acid derivatives and use in the synthesis of perindopril

专利号:UA-77987-C2
优先权日:2001-12-19
标题:Substituted derivatives of phenylpropionic acid as agonists of peroxisome proliferators activated alpha receptor, method for synthesis, pharmaceutical composition, intermediate (variants)

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:SK-287866-B6
优先权日:2002-01-30
标 题 :Process for preparation of high purity perindopril and intermediates useful in synthesis