CAS: 95-25-0; 5-Chlorobenzo[d]Oxazol-2(3H)-One

相似化合物

59-49-4 1185173-60-7 83972-30-9

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CAS号14733-75-6 5-Chloro-3-[3-[... | CAS号17929-34-9 5-Chloro-3-(hyd... | CAS号24963-36-8 2(3H)-Benzoxazo... | CAS号27087-06-5 2(3H)-Benzoxazo... | CAS号95-85-2 2-氨基-4-氯苯酚 | CAS号6358-07-2 2-氨基-4-氯-5-硝基苯酚 | CAS号16376-55-9 3-piperidinomet... | CAS号16376-61-7 2(3H)-Benzoxazo... | CAS号22876-19-3 5-氯-2-巯基苯并恶唑 | CAS号1750-45-4 6-.羟基氯唑沙宗

4-Chlorophenyl Carbonazidate 300.0~350.0 °C,26.66 Pa 条件下,反应生成 氯唑沙宗
参考文献:Azidoformates的环化.芳基叠氮基甲酸酯的环化
标题:Azidoformates的环化.芳基叠氮基甲酸酯的环化
摘要:苯基叠氮基甲酸酯在邻位直接受到氮的攻击,在"喷雾热解"中产生苯并恶唑酮,而α-萘基叠氮甲酸酯仅通过β-攻击产生萘并恶唑酮.联苯-2-基叠氮基甲酸酯通过邻环的氮原子攻击而反应生成7-苯基苯并恶唑酮和氮杂ze,而2,6-二甲基叠氮基甲酸酯反应生成的内-Diels-Alder二聚体为6-异氰基-2,6-二甲基环己-2,4-二烯酮在相同条件下.
DOI:10.1039/c39810000241

专利信息

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-10913749-B2
优先权日:2015-05-07
标 题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-11136335-B2
优先权日:2016-06-30
标题:Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHASE CHARLES E; CHOI HYEONG-WOOK; ENDO ATSUSHI; FANG FRANCIS G; KIM DAE-SHIK
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

专利号:US-9567308-B1
优先权日:2015-07-23
标 题:Process for the synthesis of chlorzoxazone
发明人：BOGOGNA LUIGI; CICIONE LAVINIA; BAROZZA ALESSANDRO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of chlorzoxazone (1) from 4-chloro-2-aminophenol and ethyl chloroformate in the presence of a base. n n n n n n n n n n The process is particularly advantageous because it uses ethyl chloroformate instead of triphosgene, a highly dangerous reagent that releases phosgene and must be handled with extremely strict procedures to guarantee the safety of operators in industrial facilities. n Ethyl chloroformate allows the possibility of working with a number of solvents, including water. n The yield and purity of the product obtained are very high.

专利号:US-2014378538-A1
优先权日:2011-12-14
标 题:Methods of responding to a biothreat
发明人：BANCEL STEPHANE
权利人:MODERMA THERAPEUTICS INC
摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.

专利号:US-2021062179-A1
优先权日:2015-02-26
标题 :Microsomal bioreactor for synthesis of drug metabolites
发明人：KRISHNAN SADAGOPAN; WALGAMA CHARUKSHA THAMEERA; NERIMETLA RAJASEKHARA REDDY
权利人:UNIV OKLAHOMA STATE
摘要:Reusable microsomal biocatalytic systems (bioreactors) constructed on carbon nanostructure modified electrodes are provided. The bioreactors comprise stable, biologically active immobilized enzymes such as human cytochromes P 450 (CYPs) and their redox partner proteins, e.g. CYP-NADPH (reduced nicotinamide adenine dinucleotide phosphate) reductases (CPR), on the carbon nanostructure surface. The immobilized enzymes may be present in liver microsomes, such as human liver microsomes (HLM) or as bactosomes, S9 fractions, etc. The bioreactors are used, for example, for synthesizing metabolites of interest from compounds such as drugs that are catabolized by the enzymes.