专利号:EP-1486498-A1 优先权日:1998-11-23 标 题 :Process and intermediates for growth hormone secretagogues 发明人:CHIU CHARLES KWOK-FUNG; GRIFFITH DAVID ANDREW 权利人:PFIZER PROD INC 摘要:This invention relates to a process for preparing compounds of the Formulan nwherein R 1 , R 2 and Pt are as defined in the specification, which are intermediatesnin the synthesis of certain growth hormone secretagogue compounds. Thisninvention further relates to processes for preparing the growth hormonensecretagogues. The invention also relates to the compound of Formula I whereinnR 1 is H, R 2 is 2,2,2-trifluoromethyl and Pt is Boc.
专利号:US-6686471-B2 优先权日:1998-11-23 标 题:Process and intermediates for growth hormone secretagogues 发明人:CHIU CHARLES K; GRIFFITH DAVID A 权利人:PFIZER 摘要:This invention relates to a process for preparing compounds of the Formula I, n wherein R 1 , R 2 and Pt are as defined in the specification, which are intermediates in the synthesis of certain growth hormone secretagogue compounds. This invention further relates to processes for preparing the growth hormone secretagogues. The invention also relates to the compound of Formula I wherein R 1 is H, R 2 is 2,2,2-trifluoromethyl and Pt is Boc.
专利号:EP-1004583-B1 优先权日:1998-11-23 标题:Process and hydantoin intermediates for the synthesis of growth hormone secretagogues
专利号:EP-1401829-B1 优先权日:2001-06-15 标题 :Novel heterocyclic antibacterial compounds 发明人:ZHI CHENGXIN; WRIGHT GEORGE E 权利人:MICROBIOTIX INC 摘要:The invention provides heterocyclic organic compounds that inhibit bacterial DNA polymerase IIIC and type II bacterial topoisomerase. The invention further provides compounds that are useful as intermediates in the synthesis of such heterocyclic organic compounds. Syntheses and uses of such heterocyclic organic molecules are also described.
专利号:DE-69919663-T2 优先权日:1998-11-23 标 题 :Processes and hydantoin intermediates for the synthesis of wax hormone secretion promoters
专利号:EP-1004583-A2 优先权日:1998-11-23 标题:Process and hydantoin intermediates for the synthesis of growth hormone secretagogues
参考文献:10.1016/j.farmac.2005.04.007 摘要:Tosco P, Bertinaria M, Di Stilo A, Cena C, Fruttero R, Gasco A. Non-imidazole histamine NO-donor H3-antagonists. Farmaco. 2005 Jun;60(6-7):507–12. doi: 10.1016/j.farmac.2005.04.007.