CAS: 84-37-7; Pseudoyohimbine

上下游产品

育亨宾 Yohimbine 146-48-5
Rac-17α-Hydroxy-3β-Yohimban-16α-Carboxylic Acid Methyl Ester 84-37-7
Pseudo-β-Yohimbine 549-82-6
17-Oxo-Yohimbane-16-Carboxylic Acid Methyl Ester 114030-03-4
(-)-3-Iso-19,20-Dehydro-β-Yohimbine 295790-93-1
Methyl (1R,2R,6R)-2-(1,3-Dioxolan-2-Ylmethyl)-6-Hydroxy-3-[[2-(1H-Indol-3-yl)Ethylamino]Methyl]Cyclohex-3-Ene-1-Carboxylate 297131-94-3

📜育亨宾置于盐酸,Mercury(II) Diacetate,锌体系中,化学反应生成 (3B)-17Alpha-羟基育亨宾-16B-羧酸甲酯
参考文献:育亨宾型生物碱的氧化重排的再研究.a部分.假吲哚基(= 1,2-二氢-3 H-吲哚-3-一)衍生物的形成
标题:育亨宾型生物碱的氧化重排的再研究.a部分.假吲哚基(= 1,2-二氢-3 H-吲哚-3-一)衍生物的形成
摘要:与先前的报道相反,来自阿马利辛(1),育亨宾(5),哥丹宁(6),草皮酸甲酯(16)和异二十烷酸甲酯(17)的7-羟基-7 H-吲哚碱的碱基诱导重排.每个案例不仅提供了一个,而且还提供了两个在螺旋中心c(2)具有相反构型的差向异构螺-伪吲哚酚衍生物.在所有情况下,Noe实验均显示其主要成分为a型异构体(羰基位于环c和d定义的平面下方).热力学不太稳定的乙型pseudoindoxyl差向异构体4,10,12,和22 首次被分离和鉴定.
DOI:10.1002/hlca.19940770514

专利信息

专利号:US-6469065-B1
优先权日:1996-02-02
标 题:Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
发明人：GARVEY DAVID S; SCHROEDER JOSEPH D; DE TEJADA INIGO SAENEZ; GASTON RICKY D; SHELEKHIN TATIANA E; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-2005187222-A1
优先权日:1996-02-02
标题:Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds
发明人：GARVEY DAVID S; DE TEJADA INIGO S; GASTON RICKY D; KHANAPURE SUBHASH P; SHELEKHIN TATIANA E; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.

专利号:US-3003926-A
优先权日:1958-04-25
标题 :Synthesis of alkaloids
发明人：FRANK WEISENBORN; PAN SAMUEL C
权利人:OLIN MATHIESON

专利号:CN-120004790-A
优先权日:2023-11-15
标 题 :Synthesis method of spiro oxindole, ke Nayin and yohimbine alkaloid and derivatives thereof