CAS: 81338-23-0; D-Ap7
该化合物是一种合成氨基酸衍生物,作为NMDA(N-甲基-D-partate)受体的选择性敌体,对合成可塑性塑料和记忆功能至关重要.该化合物具有磷酸组的特点,可增强该组的稳定性和生物活性.D-AP7的特征是它能够抑制...
- 英文名称D-Ap7
- 中文名称D(-)-2-氨基-7-膦酰庚酸
- IUPAC名称(R)-2-amino-7-phosphonoheptanoic acid
- 其它别名Heptanoicacid, 2-amino-7-phosphono-, (R)-; (-)-2-Amino-7-phosphonoheptanoic acid; (R)-AP7; D-(-)-2-Amino-7-phosphonoheptanoate; D-2-Amino-7-phosphonoheptanoicacid; D-AP 7
- CAS编号81338-23-0
- MFCD编号:MFCD00070086
- EINECS号:636-019-1
- FDA UNII编号:89FET0690I
- 分子式:C7H16NO5P分子量:225.18
- 产品CID: 1807192
- 产品分类有机原料 → 有机酸及其衍生物 → 羧酸及其衍生物
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
(2R)-2-Azaniumyl-7-Diethoxyphosphorylheptanoate合成工艺路线路线简述
📜二乙基(5-溴戊基)膦酸酯置于盐酸,甲烷体系中,化学反应生成 D(-)-2-氨基-7-膦酰庚酸
参考文献:Andronova; Maleev; Ragulin,Russian Journal Of General Chemistry,1996,Vol. 66,# 7,P. 1068-1071
标题:Andronova; Maleev; Ragulin,Russian Journal Of General Chemistry,1996,Vol. 66,# 7,P. 1068-1071
海关参考信息
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2905130000-正丁醇
2912110000-甲醛
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主要参考文献
1: Forcelli PA, Wellman LL, Malkova L. Blockade of glutamatergic transmission in the primate basolateral amygdala suppresses active behavior without altering social interaction. Behav Neurosci. 2017 Apr;131(2):192-200. doi: 10.1037/bne0000187. Epub 2017 Feb 20.
2: Chitravanshi VC, Kawabe K, Sapru HN. Stimulation of the hypothalamic arcuate nucleus increases brown adipose tissue nerve activity via hypothalamic paraventricular and dorsomedial nuclei. Am J Physiol Heart Circ Physiol. 2016 Aug 1;311(2):H433-44. doi: 10.1152/ajpheart.00176.2016. Epub 2016 Jul 8.
3: Diniz CR, Casarotto PC, Joca SR. NMDA-NO signaling in the dorsal and ventral hippocampus time-dependently modulates the behavioral responses to forced swimming stress. Behav Brain Res. 2016 Jul 1;307:126-36. doi: 10.1016/j.bbr.2016.03.037. Epub 2016 Mar 22. doi: 10.1016/j.pbb.2016.01.003. Epub 2016 Jan 11. doi: 10.1007/s11481-015-9632-y. Epub 2015 Oct 10. doi: 10.1016/j.pnpbp.2015.06.004. Epub 2015 Jun 11. doi: 10.1523/JNEUROSCI.4307-14.2015.
合成参考文献
参考文献:10.1073/pnas.2005463117
摘要:Abrams RPM, Yasgar A, Teramoto T, Lee MH, Dorjsuren D, Eastman RT, Malik N, Zakharov AV, Li W, Bachani M, Brimacombe K, Steiner JP, Hall MD, Balasubramanian A, Jadhav A, Padmanabhan R, Simeonov A, Nath A. Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proc Natl Acad Sci U S A. 2020 Dec 08;117(49):31365–75.
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