CAS: 7113-10-2; 2-Phenylthiazole-4-Carboxylic Acid

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CAS号59937-01-8 2-苯基噻唑-4-甲酸乙酯 | CAS号7113-02-2 2-苯基噻唑-4-羧酸甲酯 | CAS号1113-59-3 3-溴丙酮酸 | CAS号2227-79-4 硫代苯甲酰胺 | CAS号23780-13-4 (2-苯基噻唑-4-基)甲醇 | CAS号38707-83-4 2-苯基-1,3-噻唑-4,5-二羧酸 | CAS号4771-31-7 4-(氯甲基)-2-苯基-1,3-噻唑 | CAS号54986-96-8 diethyl 2-pheny... | CAS号99380-81-1 2-苯基噻唑烷-4-羧酸甲酯 | CAS号100-52-7 苯甲醛 | CAS号36094-04-9 2-苯基-1,3-噻唑-4-甲酰氯 | CAS号10045-52-0 1-(2-苯基-1,3-噻唑-... | CAS号7113-02-2 2-苯基噻唑-4-羧酸甲酯 | CAS号400775-03-3 2-phenyl-1,3-th...

📜硫代苯甲酰胺置于lithium Hydroxide Monohydrate体系中,用 四氢呋喃,甲醇,乙醇,水 作为反应溶剂,化学反应 8.0H,反应生成 2-苯基-1,3-噻唑-4-甲酸
参考文献:发现了2-苯基噻唑-4-羧酸,一种新型有效的黄嘌呤氧化酶抑制剂.
标题:发现了2-苯基噻唑-4-羧酸,一种新型有效的黄嘌呤氧化酶抑制剂.
摘要:黄嘌呤氧化酶(xo)在产生尿酸中起着重要作用,因此xo抑制剂被认为是高尿酸血症和痛风的有前途的疗法之一.我们先前已经报道了一系列带有吡唑骨架的xo抑制剂,以扩展当前xo抑制剂的化学空间.在这里,我们描述了进一步的结构优化,以通过用该领域未开发的5个杂环骨架取代非布索坦的噻唑环来探索最佳杂环.所有这些努力导致了化合物8的鉴定,该化合物是一种具有新型2-苯基噻唑-4-羧酸支架的有效xo抑制剂(ic50 = 48.6 Nm).此外,铅化合物8在草酸钾-次黄嘌呤诱导的高尿酸血症小鼠中表现出低尿酸作用.
DOI:10.1016/j.Bmcl.2019.01.005

专利信息

专利号:US-2013012719-A1
优先权日:2011-07-08
标 题 :Convenient Synthesis of Azolines to Azoles
发明人：WILLIAMS TRAVIS J; DAWSEY ANNA C; LI VINCENT; HAMILTON KIMBERLY C; WANG JIANMEI
权利人:UNIV SOUTHERN CALIFORNIA; WILLIAMS TRAVIS J; DAWSEY ANNA C; LI VINCENT; HAMILTON KIMBERLY C; WANG JIANMEI
摘要:Azolines are oxidized in the presence of a copper-containing catalyst to azoles in the presence of molecular oxygen. A synthetic scheme converting azolines azoles is also provided.

专利号:WO-2006079916-A1
优先权日:2005-01-26
标 题 :Thieno [2,3-d] pyrimidine compounds as inhibitors of adp-mediated platelets aggregation
发明人：ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; RAHMAN HAYAT; SCHWEITZER BARBARA ANN; TENBRINK RUTH ELIZABETH
权利人:PHARMACIA & UPJOHN CO LLC; ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; RAHMAN HAYAT; SCHWEITZER BARBARA ANN; TENBRINK RUTH ELIZABETH
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I): wherein A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2, R4, R5, and R6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2006211603-A1
优先权日:2004-08-18
标 题:Ramoplanin derivatives possessing antibacterial activity
发明人：RAJU BORE G; CIABATTI ROMEO; MAFFIOLI SONIA I; SINGH UPINDER; ROMANO GABRIELLA; MICHELUCCI ELENA; TISENI PAOLO S; CANDIANI GIANPAOLO; KIM BUM; O'DOWD HARDWIN
权利人:VICURON PHARM INC
摘要:Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.