专利号:US-2024026314-A1 优先权日:2020-11-25 标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds 发明人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN 权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN 摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.
专利号:EP-4251758-A1 优先权日:2020-11-25 标 题:Polypeptides for use in the synthesis of bioactive phenolic compounds
专利号:WO-2022109736-A1 优先权日:2020-11-25 标题:Polypeptides for use in the synthesis of bioactive phenolic compounds
专利号:CA-3202377-A1 优先权日:2020-11-25 标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
1: Singh R, Singh B, Singh A, Rana S, Sharma K, Viswakarma P, Gopu B, Nalli Y. Canniprene B, a new prenylated dihydrostilbene with cytotoxic activities from the leaves of Cannabis sativa. Nat Prod Res. 2024 Jul 11:1-9. doi: 10.1080/14786419.2024.2376348. Epub ahead of print. 80(3):731-734. doi: 10.1021/acs.jnatprod.6b01126. Epub 2017 Feb 6. 80:67-134. doi: 10.1016/bs.apha.2017.03.004. Epub 2017 Jun 5. 109(3):693-707. doi: 10.1111/tpj.15588. Epub 2021 Dec 6. 0(0):10.2217/fvl-2021-0309. doi: 10.2217/fvl-2021-0309. Epub 2022 Apr 4.
合成参考文献
参考文献:10.1021/acs.jnatprod.6b01126 摘要:Allegrone G, Pollastro F, Magagnini G, Taglialatela-Scafati O, Seegers J, Koeberle A, Werz O, Appendino G. The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains. J Nat Prod. 2017 Mar 24;80(3):731–4. doi: 10.1021/acs.jnatprod.6b01126.