CAS: 705-60-2; (2-Nitroprop-1-Enyl)Benzene

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Nitroethane benzaldehyde 1-phenylpropene 2-nitro-1-phenylpropan-1-ol H-pyrazole5-methyl-5-nitro-4-phenyl-4,5-dihydro-1H-pyrazole RS,2SR)-2-nitro-1-phenyl-propyl)-morpholine4-((1RS,2SR)-2-nitro-1-phenyl-propyl)-morpholine RS,2RS)-2-nitro-phenyl-propyl)-morpholine4-((1RS,2RS)-2-nitro-phenyl-propyl)-morpholine (2-oxo-1-phenyl-propyl)-malonic acid diethyl ester

📜1-丙烯基苯置于亚硝酸特丁酯,2,2,6,6-四甲基哌啶氧化物体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 12.0H,反应生成 苯,(2-硝基-1-丙烯基)-,(E)-
参考文献:一种前所未有的氨基-三甲基甲烷化学的去质子化方法:复杂氨基循环的区域,非对映和对映选择性合成
标题:一种前所未有的氨基-三甲基甲烷化学的去质子化方法:复杂氨基循环的区域,非对映和对映选择性合成
摘要:报道了使用脱质子化策略简化氨基-三亚甲基甲烷供体的合成过程,这是从商业和廉价的材料分两个步骤进行的,首次实现了氨基-三甲甲烷化学.广泛的环加成受体(七个不同类别)参与了化学,化学,区域,非对映和对映选择性反应生成各种类型的高度有价值的复杂氨基循环.在不分离粗产物的情况下,进行了进一步完善初始氨基循环的多个衍生化反应.最终,我们应用氨基三甲撑甲烷化学方法以8个线性步骤和7.5%的总收率合成了一种潜在的药物,以前是18个线性步骤和0.6%的总收率实现的.
DOI:10.1002/anie.201805876

专利信息

专利号:US-4000197-A
优先权日:1973-07-23
标 题 :Asymmetric synthesis of phenylisopropylamines
发明人：BARFKNECHT CHARLES F; NICHOLS DAVID E
权利人:UNIV IOWA RES FOUND
摘要:The synthesis of enantiomers of a series of methoxy- and alkyl- substituted phenylisopropylamines is described. The synthesis comprises reducing the imines, formed by the reaction of appropriate phenylacetones with either (+)- or (-)-α-methylbenzylamine, by low-pressure reduction techniques, and subsequently subjecting the optically active N-(α-phenethyl)phenylisopropylamine derivative to hydrogenolysis. The hydrogenolysis products are characterized by enantiomeric purities in the range of 96 - 99%. Yields of products are approximately 60%.

专利号:US-8071782-B2
优先权日:2007-10-02
标 题 :Synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles
发明人：DENG XIAOHU; MANI NEELAKANDHA S
权利人:DENG XIAOHU; MANI NEELAKANDHA S; JANSSEN PHARMACEUTICA NV
摘要:This invention concerns the synthesis of highly substituted pyrazoles, which are structural components of pharmacological compounds, through reaction of hydrazones with nitroolefins.

专利号:US-2023117370-A1
优先权日:2020-04-17
标 题:Regioselective synthesis of substituted compounds
发明人：BEAUDRY CHRISTOPHER M; ZHANG XIAOJIE
权利人:UNIV OREGON STATE
摘要:Disclosed herein are embodiments of a method for making substituted compounds with specific and selectable regiochemistry. Also disclosed are compounds made by the method. The method may comprise contacting a compound having a formula Iwith a compound according to formula IIin the presence of a Lewis acid to form a phenol compound according to formula III and/or a benzofuranone compound according to formula IV

专利号:US-8791273-B2
优先权日:2009-11-05
标 题 :4R,5S-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with nootropic activity
发明人：KALVINS IVARS; LEBEDEVS ANTONS; CERNOBROVIJS ALEKSANDRS; DAMBROVA MAIJA; ZVEJNIECE LIGA; VORONA MAKSIMS; VEINBERGS GRIGORIJS
权利人:KALVINS IVARS; LEBEDEVS ANTONS; CERNOBROVIJS ALEKSANDRS; DAMBROVA MAIJA; ZVEJNIECE LIGA; VORONA MAKSIMS; VEINBERGS GRIGORIJS; JSC GRINDEKS
摘要:The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.

专利号:US-9744391-B2
优先权日:2009-11-26
标 题:Use of metal-accumulating plants for implementing chemical reactions
发明人：GRISON CLAUDE; ESCARRE JOSE
权利人:CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 2 SCIENCES ET TECHNIQUES
摘要:A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others.

专利号:US-9388345-B2
优先权日:2012-07-03
标题:Hydrocarbon synthesis methods, apparatus, and systems
发明人：MCNEFF CLAYTON V; MCNEFF LARRY C; NOWLAN DANIEL THOMAS; YAN BINGWEN; GREUEL PETER G
权利人:SARTEC CORP
摘要:Embodiments of the invention include apparatus and systems for hydrocarbon synthesis and methods regarding the same. In an embodiment, the invention includes a process for creating a hydrocarbon product stream comprising reacting a reaction mixture in the presence of a catalyst inside of a reaction vessel to form a product mixture, the reaction mixture comprising a carbon source and water. The temperature inside the reaction vessel can be between 450 degrees Celsius and 600 degrees Celsius and the pressure inside the reaction vessel can be above supercritical pressure for water. In an embodiment, the invention includes an extrusion reactor system for creating a hydrocarbon product stream. The temperature inside the extrusion reactor housing between 450 degrees Celsius and 600 degrees Celsius. Pressure inside the reaction vessel can be above supercritical pressure for water. Other embodiments are also included herein.