CAS: 665-46-3; Tetraethylammonium (Fluoride)

相似化合物

56-34-8 71-91-0 68-05-3

上下游产品

CAS号77-98-5 四乙基氢氧化铵 | CAS号56-34-8 四乙基氯化铵 | CAS号71-91-0 四乙基溴化铵 | CAS号42539-97-9 四乙基氟化铵三氢氟酸盐

四乙基溴化铵置于氢氟酸体系中,用 水 作为反应溶剂,化学反应 3.0H,以6.94 G的收率获得产物四乙基氟化铵水合物
参考文献:一种氟化盐离子液体的合成方法
标题:一种氟化盐离子液体的合成方法
摘要:本发明涉及有机化学合成领域,具体涉及一种氟化盐离子液体的合成方法.本发明是向取卤化咪唑等原料中加入过量的氢氟酸,氟化铵或氟化氢铵,密闭搅拌并升温至50‑70°C,充分反应至少3H,得到未脱水的氟化盐离子液体,检测纯化并脱水后,得到粘稠液体,对粘稠液体进行检测,检测合格后得到氟化盐离子液体.本发明方法工艺简易,无有机溶剂,无废弃物,终产物纯度高.

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-7247287-B2
优先权日:2003-06-11
标 题 :Synthesis of aluminophosphates and silicoaluminophosphates
发明人：CAO GUANG; SHAH MATU J
权利人:EXXONMOBIL CHEM PATENTS INC
摘要:The invention is directed to a method of synthesising silicoaluminophosphate and aluminophosphate molecular sieves using synthesis templates that contain at least one template of general formula R 1 R 2 N—R 3 , wherein R 1 and R 2 are independently selected from the group consisting of alkyl groups having from 1 to 3 carbon atoms and hydroxyalkyl groups having from 1 to 3 carbon atoms; R 3 is selected from the group consisting of 4- to 8-membered cycloalkyl groups, optionally substituted by 1 to 3 alkyl groups having from 1 to 3 carbon atoms, and 4- to 8-membered heterocyclic groups having from 1 to 3 heteroatoms, said heterocyclic groups being optionally substituted by 1 to 3 alkyl groups having from 1 to 3 carbon atoms and the heteroatoms in said heterocyclic groups being selected from the group consisting of O, N, and S. In particular, the present invention relates to the synthesis of silicoaluminophosphate molecular sieves of the CHA framework type having a low silicon to aluminium atomic ratio.

专利号:WO-2025044766-A1
优先权日:2023-08-31
标题:Use of silicon dioxide microspheres in synthesis of ultra-long oligonucleotide and method for synthesizing ultra-long oligonucleotide
发明人：SHI YONGYONG; ZHANG MANCANG; WANG LIBING; GAO PANPAN; FANG JUN
权利人:UNIV SHANGHAI JIAOTONG; SHANGHAI DYNEGENE TECH CO LTD
摘要:The present invention relates to the technical field of oligonucleotide synthesis. Disclosed are the use of silicon dioxide microspheres in the synthesis of an ultra-long oligonucleotide and a method for synthesizing an ultra-long oligonucleotide, wherein the silicon dioxide microspheres have a specific surface area of less than 1 m2/g, and preferably, the silicon dioxide microspheres have modification groups on the surface. The method for synthesizing an ultra-long oligonucleotide comprises: performing a coupling reaction on a nucleoside phosphoramidite synthesis unit using the silicon dioxide microspheres having modification groups on the surface as carriers under coupling reaction conditions. The prepared carriers can be used to prepare an ultra-long oligonucleotide.

专利号:US-6540970-B1
优先权日:1999-11-18
标题:Method for the synthesis of molecular sieves
发明人：STROHMAIER KARL G; VAUGHAN DAVID E W
权利人:EXXON MOBIL CHEM PATENTS INC
摘要:The present invention provides a method for the synthesis of MeAPO molecular sieves which includes the following steps: providing a source of alumina, a source of phosphorus, water, and a template suitable for forming a MeAPO molecular sieve; providing a source of metal (Me) including metal particles, the metal particles measuring, in their largest dimension, equal to or less than five nanometers; providing a water soluble organic solvent capable of solubilizing the source of metal; forming a synthesis mixture from the source of alumina, the source of phosphorus, the water, the template, the source of metal, and the solvent; and forming a MeAPO molecular sieve from the synthesis mixture.

专利号:WO-2024058665-A1
优先权日:2022-09-15
标 题:One-pot synthesis of 6-l-[18f] fluoro-3,4-dihydroxyphenylalanine (6-l-[18f] fdopa).
发明人：LUURTSEMA GEERT; KWIZERA CHANTAL; BLOK SIMON NIELS; FARINHA ANTUNES INES; ELSINGA PHILIPPUS HEIN; DE VRIES ERIK
权利人:UNIV GRONINGEN; ACADEMISCH ZIEKENHUIS GRONINGEN
摘要:The invention relates to the field of medicinal chemistry and radiopharmaceuticals, in particular to means, methods and cassettes for the automated synthesis of the radiotracer 6- L -[ 18 F]fluoro-3,4- dihydroxyphenylalanine (6- L -[ 18 F]FDOPA). Provided is a method for the one-pot synthesis of 6- L -[ 18 F]FDOPA comprising contacting a BOC- protected stannyl precursor of the formula I with [ 18 F] Tetraethylammonium fluoride ([ 18 F]Et 4 NF) in the presence of the Cu-catalyst Cu(Impy) 4 (OTf) 2 .

专利号:US-11220513-B2
优先权日:2015-04-30
标题:Chromium-mediated coupling and application to the synthesis of halichondrins
发明人：KISHI YOSHITO; YAN WUMING; LI JINGWEI; LI ZHANJIE; YAHATA KENZO
权利人:HARVARD COLLEGE
摘要:The present invention provides unified synthesis of the C1-C19 building blocks of halichondrins and analogs thereof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hybridized carbon. The provided efficient selective coupling reactions can allow easy access to the C1-C19 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates.