CAS: 62567-42-4; 6-(2-Hydroxyphenyl)Pyridazin-3(2H)-One
该化合物是一种化学化合物,其特征为:丙基苯核心结构,其特征为:丙烯酮环与一个酮和氢氧基代苯组结合;该化合物一般具有极地溶剂中的中等溶解性等特性,因为氢可结合氢;其分子结构表明潜在的生物活动,使其对药用化学和药理学感兴趣;该氢氧基组可能加强其回动性和与生物目标的相互作用;此外,该化合物可能显示出各种物理特性,包括熔点和沸点,这些点受其分子相互作用的影响;与许多有机化合物一样,其稳定性可能受到诸如pH和温度等环境因素的影响.
- 英文名称6-(2-Hydroxyphenyl)Pyridazin-3(2H)-One
- 中文名称6-(2-羟基苯基)哒嗪-3-醇
- IUPAC名称6-(2-hydroxyphenyl)pyridazin-3(2H)-one
- 其它别名6-(2-羟苯基)-3(2H)-哒嗪酮; 6-(2-Hydroxyphenyl)-Pyridazin-3(2H)-One&
- CAS编号62567-42-4
- MFCD编号:MFCD07369768
- EINECS号:263-598-4
- 分子式:C10H8N2O2分子量:188.19
- 产品CID: 1607160
- 产品分类有机原料→分子砌块→芳杂环类化合物→哒嗪类化合物
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MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号127-68-4 间硝基苯磺酸钠 | CAS号39499-60-0 6-(2-hydroxy-ph... | CAS号118-93-4 邻羟基苯乙酮 | CAS号298-12-4 乙醛酸 | CAS号7250-94-4 2-乙酰氧基苯乙酮合成工艺路线路线简述
- 合成目标产物 6-(2-Hydroxyphenyl)-Pyridazin-3(2H)-One 主要起始原料 Benzenebutanoic Acid, α,2-Dihydroxy-γ-Oxo-
- (文献来源)合成步骤主要原料 Benzenebutanoic Acid, α,2-Dihydroxy-γ-Oxo-
📜1,4A-Dihydropyridazino[1,6-B][1,2]Benzoxazol-2-One 以92%的收率获得产物
参考文献:Hasegawa H.; Arai H.; Igeta H.,Chem. And Pharm. Bull.,1977,25,No 1,192-195
标题:Hasegawa H.; Arai H.; Igeta H.,Chem. And Pharm. Bull.,1977,25,No 1,192-195
海关参考信息
- 2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸
2905199090-其他饱和一元醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-4152517-A
优先权日:1977-10-19
标题:Synthesis of 6-(2-hydroxyphenyl)-3(2H)-pyridazinones from trihalocarbinols
发明人：LEVINSON SIDNEY H; MENDELSON WILFORD L
权利人:SMITHKLINE CORP
摘要:A new synthesis for the preparation of 6-(2-hydroxyphenyl)-3-pyridazinones whose key reaction is cyclizing a 1,1,1-trihalo-2-hydroxy-4-(2-hydroxyphenyl)-1-butanone with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinones are important intermediates for preparing medicinally active compounds.
专利号:US-4193941-A
优先权日:1977-10-19
标 题:1,1,1-Trihalo-2-hydroxy-4-(2-hydroxyphenyl)-4-butanones
发明人：LEVINSON SIDNEY H; MENDELSON WILFORD L
权利人:SMITHKLINE CORP
摘要:A new synthesis for the preparation of 6-(2-hydrophenyl)-3-pyridazinones whose key reaction is cyclizing a 1,1,1-trihalo-2-hydroxy-4-(2-hydroxyphenyl)-4-butanone with hydrazine. 6-(2-Hydroxyphenyl)-3-pyridazinones are important intermediates for preparing medicinally active compounds especially 3-[2-(3-tert.-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine or its nontoxic acid addition salts. The invention claimed here is the trihalocarbinol intermediates.
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📌 第三方产品分析报告
主要参考文献
参考标题:One-Pot Preparation Of 6-Substituted 3(2H)-Pyridazinones From Ketones作者:W. J. Coates,A. Mckillop
摘要:A One-Pot Process For The Preparation Of 6-Phenyl-3(2H)-Pyridazinone From Acetophenone And Glyoxylic Acid Has Been Investigated And Shown To Have Wide Utility In The Preparation Of 6- And 5,6-Substituted 3(2H)-Pyridazinones. Limitations To The Process Encountered With 2′-Hydroxyacetophenone And With Basic Heteroaromatic Ketones Have Been Overcome, And The Processes Described Offer The Rapid And Efficient Synthesis Of Many 6-Substituted Pyridazinones From Readily Available Ketones.
合成参考文献
参考文献:10.1016/j.ejmech.2021.114098
摘要:Shi Y, Zhang H, Song Q, Yu G, Liu Z, Zhong F, Tan Z, Liu X, Deng Y. Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease. European Journal of Medicinal Chemistry. 2022 Feb;230():114098. doi: 10.1016/j.ejmech.2021.114098.
摘要:Haider, N.; Holzer, W., Science of Synthesis, (2004) 16, 187.
摘要:Haider, N.; Holzer, W., Science of Synthesis, (2004) 16, 134.
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