专利号:CN-118530135-A 优先权日:2024-04-22 标题:A kind of synthesis process of continuous synthesis of salicylamide
专利号:US-7179918-B2 优先权日:2001-06-11 标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis 发明人:CANAN KOCH STACIE S; ALEXANDER THERESE N; BURKE BENJAMIN J; JEWELL TANYA M; KUCERA DAVID J; LINTON MARIA ANGELICA; MITCHELL JR LENNERT J; REICH SIEGFRIED H; SKALITZKY DONALD J; TATLOCK JOHN H; VARNEY MICHAEL D; VIRGIL SCOTT C; WEBBER STEPHEN E; WORLAND STEPHEN T; BARVIAN MARK; BOLTON GARY; BOYER JR FREDERICK EARL; MACHAK JEFFREY J; HOLLER TOD; MURPHY SEAN T; MELNICK MICHAEL; JOSYULA VARA PRASAD 权利人:AGOURON PHARMA 摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
专利号:US-7731932-B2 优先权日:2003-09-04 标 题 :Methods of processing nanocrystals, and compositions, devices and systems including same 发明人:SCHER ERIK C; BURETEA MIHAI A; WHITEFORD JEFFERY A; MEISEL ANDREAS P 权利人:NANOSYS INC 摘要:Methods of processing nanocrystals to remove excess free and bound organic material and particularly surfactants used during the synthesis process, and resulting nanocrystal compositions, devices and systems that are physically, electrically and chemically integratable into an end application.
专利号:US-8440842-B2 优先权日:2007-07-16 标题:Antimicrobial compounds, their synthesis and their use for treatment of mammalian infections 发明人:MOELLMANN UTE; MAKAROV VADIM; STEWART COLE T 权利人:MOELLMANN UTE; MAKAROV VADIM; STEWART COLE T; LEIBNIZ INST NATURSTOFF FORSCH 摘要:The present invention relates to compounds of Formula (I) n nor salts thereof wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and other variables enumerated under one or more of same are as defined herein. Compounds of Formula I have activity as antimicrobial agents. Also disclosed are pharmaceutical compositions and methods of treating and preventing microbial infections in mammals, for example, a tuberculosis or leprosy infection, which employ compounds of Formula (I) or salts thereof.
专利号:SU-1739849-A3 优先权日:1987-08-03 标题 :Method for synthesis of benzamide derivatives or their pharmacologically acceptable salts
专利号:US-5021444-A 优先权日:1986-01-28 标题 :Thianaphthene derivatives 发明人:TRADA ATSUSUKE; AMEMIYA YOSHIYA; MATSUDA KEIICHI; OSHIMA TAKESHI 权利人:SANKYO CO 摘要:Compounds of formula (I): ##STR1## (wherein n is 0 or 1, R 1 and R 2 are hydrogen or alkyl, one of A 1 and A 2 is --Z--Y and the other is --W--COOH, where W and Z are alkenylene or alkylene and Y is imidazolyl or pyridyl, and the broken lines represent two single bonds or one single bond and one double bond) and their salts, esters and amides have the ability to inhibit the synthesis of thromboxane A 2 and hence are useful in the treatment of prophylaxis of thrombotic conditions. They may be prepared by introducing an imidazolyl or pyridyl group into the corresponding compound in which Y is replaced by an active group or atom.
[参考文献]: L Guoguang, Et Al. The Formation Of 2-Chlorobenzamide Upon Hydrolysis Of The Benzoylphenylurea Insecticide 1-(2-Chlorobenzoyl)-3-(4-Chlorophenyl) Urea In Different Water Systems. J Agric Food Chem. 2001 Mar;49(3):1304-8. [参考文献]: Z Qingxiang, Et Al. Study On The Hydrolysis Of 2-Chlorobenzamide. J Agric Food Chem. 2000 Jun;48(6):2572-5.
合成参考文献
摘要:Khartulyari, A.; Maier, M. E., Science of Synthesis Knowledge Updates, (2010) 3, 80. 摘要:Khartulyari, A.; Maier, M. E., Science of Synthesis Knowledge Updates, (2010) 3, 58. 摘要:Glushkov, V. A.; Shklyaev, Yu. V., Science of Synthesis Knowledge Updates, (2018) 3, 254. 摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 286. 摘要:Asano, Y., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 258.