CAS: 608-07-1; O-Methylserotonin

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CAS号61675-19-2 5-甲氧基-3-(2-硝基乙烯基)吲哚 | CAS号73-31-4 褪黑素 | CAS号68935-49-9 5-methoxy-3-(2-... | CAS号1006-94-6 5-甲氧基吲哚 | CAS号67199-10-4 5-methoxy-Nb-(m... | CAS号102016-76-2 N-(2-(5-methoxy... | CAS号627086-10-6 2-(1-methanesul... | CAS号58635-45-3 methyl N-[2-(1H... | CAS号112081-40-0 N-[2-(5-methoxy... | CAS号111915-67-4 1-[2-(5-methoxy... | CAS号104510-12-5 N-[2-(5-methoxy... | CAS号50-67-9 5-羟基色胺 | CAS号3589-73-9 6-甲氧基哈马兰 | CAS号2009-03-2 N,O-dimethylser... | CAS号29745-42-4 N-[2-(5-methoxy... | CAS号96096-55-8 5-甲氧基-N-甲基-N-异丙基色胺 | CAS号73-31-4 褪黑素 | CAS号139564-01-5 5-甲氧基-N-环丙酰基色胺

褪黑素置于recombinant Arabidopsis Thaliana Histone Deacetylase 14体系中,用 Aq. Buffer 作为反应溶剂,化学反应生成 5-甲氧基色胺
参考文献:水稻组蛋白脱乙酰基酶10和拟南芥组蛋白脱乙酰基酶14基因编码n-乙酰5-羟色胺脱乙酰酶,催化n-乙酰5-羟色胺转化为5-羟色胺,这是植物褪黑素生物合成的逆反应.
标题:水稻组蛋白脱乙酰基酶10和拟南芥组蛋白脱乙酰基酶14基因编码n-乙酰5-羟色胺脱乙酰酶,催化n-乙酰5-羟色胺转化为5-羟色胺,这是植物褪黑素生物合成的逆反应.
摘要:在植物中,褪黑激素的产生受到严格的调节,这与其褪色素的前体的产生不同,后者是对衰老和病原体暴露等刺激产生高度诱导作用的.外源性5-羟色胺处理不会在植物中极大地诱导n-乙酰5-羟色胺(nas)和褪黑激素的产生,这表明从5-羟色胺生物合成褪黑激素的途径中可能存在一个或多个调控基因.在此报告中,我们发现nas在水稻幼苗中迅速大量转化为5-羟色胺,表明存在n-乙酰5-羟色胺脱乙酰基酶(asdac).为了克隆假定的asdac基因,我们筛选了4个被称为组蛋白脱乙酰基酶(hdac)的基因.)基因,但编码的蛋白质靶向叶绿体或线粒体而不是细胞核.在表达这些基因的4种重组大肠杆菌菌株中,发现一种表达水稻hdac10基因的大肠杆菌菌株能够响应于nas处理而产生5-羟色胺.重组纯化的水稻hdac10(oshdac10)蛋白对nas,N-乙酰酪胺(nat),N具有asdac酶活性-乙酰色胺和褪黑激素,对于nat具有
DOI:10.1111/jpi.12460

专利信息

专利号:US-9428524-B2
优先权日:2010-05-25
标 题:Synthetic process for the manufacture of ecteinascidin compounds
发明人：MARTIN LÓPEZ MA JESÚS; FRANCESCH SOLLOSO ANDRÉS; CUEVAS MARCHANTE MARIA DEL CARMEN
权利人:MARTIN LÓPEZ MA JESÚS; FRANCESCH SOLLOSO ANDRÉS; CUEVAS MARCHANTE MARIA DEL CARMEN; PHARMA MAR SA
摘要:This invention relates to compounds of formula II: wherein R 1 , R 2 , Prot SH , and Prot NH are as defined, to processes for the synthesis of ecteinascidins of formula I from compounds of formula II, and to processes for the synthesis of compounds of formula II.

专利号:US-10590158-B2
优先权日:2015-06-29
标题:Total synthesis of shishijimicin A and analogs thereof
发明人：NICOLAOU KYRIACOS C; LI RUOFAN; LU ZHAOYONG; SOHN TE-IK; WOODS JAMES; PITSINOS EMMANOUIL N
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present disclosure provides shishijimicin analogs of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, antibody drug conjugates of the compounds are also provided.

专利号:WO-0054773-A1
优先权日:1999-03-12
标题:Dopamine agonists in combination with nitric oxide donors, compositions and methods of use
发明人：GARVEY DAVID S
权利人:NITROMED INC; GARVEY DAVID S
摘要:The present invention is directed to novel compositions comprising at least one dopamine agonist in combination with at least one nitric oxide donor (i.e. compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are substrates for nitric oxide synthase). The novel compositions may optionally comprise at least one therapeutic agent, such as, a vasoactive agent, an antimetic agent, and mixtures thereof. The dopamine agonist is preferably apomorphine. The present invention is also directed to methods for treating and/or preventing sexual dysfunctions and/or enhancing sexual responses in patients. In other embodiments, the present invention is directed to methods treating or preventing neurodegenerative diseases, mitochondrial diseases, spinal cord injury, central or psychostimulant addiction, senile dementia, circulatory disorders, cardiovascular disorders, hyperprolactinaemia or myopia. The compounds and/or compositions of the present invention can also be provided in the form of a pharmaceutical kit.

专利号:US-11273138-B2
优先权日:2017-11-02
标 题 :Use of amino acid supplementation for improved muscle protein synthesis
发明人：WOLFE ROBERT R; FERRANDO ARNY
权利人:BIOVENTURES LLC
摘要:The present invention encompasses an amino acid composition for stimulating muscle protein synthesis. Further, the present disclosure relates generally to the use of an anabolic amino acid composition for the stimulation of muscle protein synthesis. In particular, disclosed are compositions and methods of using the same for the prevention and/or treatment of a loss of any one of muscle mass, muscle strength, muscle function, and physical function, or any combination thereof, in a mammal, especially an adult mammal. Also provided are kits comprising a composition for the stimulation of muscle protein synthesis and, in certain embodiments, instructions for administration.

专利号:US-7186709-B2
优先权日:2002-08-27
标 题:Dihydropyrancarboxamides and uses thereof
发明人：SCHREIBER STUART L; STAVENGER ROBERT A; MITCHISON TIMOTHY J; MALIGA ZOLTAN
权利人:HARVARD COLLEGE
摘要:The present invention provides novel dihydropyrancarboxamide compounds of formula (I): n nand collections of these compounds, and provides methods for the synthesis of these compounds; wherein R 1 –R 6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.

专利号:US-2018327439-A1
优先权日:2015-06-29
标题:Total synthesis of shishijimicin a and analogs thereof