CAS: 58168-20-0; Ethyl 5-Amino-4-Cyano-3-(2-Ethoxy-2-Oxoethyl)Thiophene-2-Carboxylate

1,3-丙酮二羧酸二乙酯 以44的收率获得产物5-氨基-4-氰基-3-(2-乙氧基羰甲基)噻吩-2-羧酸乙酯
参考文献: Process For The Preparation Of Strontium Ranelate[fr] Procédé De Préparation De Ranélate De Strontium
标题: Process For The Preparation Of Strontium Ranelate[fr] Procédé De Préparation De Ranélate De Strontium
摘要:本发明涉及一种从四铵盐5-[双(2-氧化-2-氧乙基)氨基]-4-氰基-3-(2-氧化-2-氧乙基)噻吩-2-羧酸盐出发合成二锶盐5-[双(2-氧化-2-氧乙基)氨基]-4-氰基-3-(2-氧化-2-氧乙基)噻吩-2-羧酸盐(锶拉内酯,式(i))的工艺,其中化合物5-[双(2-氧化-2-氧乙基)氨基]-4-氰基-3-(2-氧化-2-氧乙基)噻吩-2-羧酸盐(式(II))是本发明的新化合物,也是本发明的研究对象.

专利信息

专利号:WO-2013113319-A1
优先权日:2012-01-31
标题 :Process for the preparation of strontium ranelate, intermediate or hydrates thereof
发明人：KOFTIS THEOCHARIS V; ROHIT RAVIKANT SONI; BHARAT BECHARBHAI BODA; DIPAKKUMAR NARSIBHAI BHUT; VIMALKUMAR SUBHIRBHAI PATEL
权利人:PHARMATHEN SA; KOFTIS THEOCHARIS V; ROHIT RAVIKANT SONI; BHARAT BECHARBHAI BODA; DIPAKKUMAR NARSIBHAI BHUT; VIMALKUMAR SUBHIRBHAI PATEL
摘要:The present invention relates to an improved process for the synthesis of strontium ranelate compound of formula I or its hydrates thereof. More particularly, the present invention relates to an economically viable and industrially feasible process for the preparation of strontium ranelate, intermediate or its hydrates thereof.