CAS: 574-95-8; Aureothricin

📜N-[2-(4-Methoxyphenyl)-2,5-Dimethyl-6-Oxo-[1,3]Dithiino[5,4-B]Pyrrol-7-Yl]Propanamide 反应生成 金丝菌素
参考文献:Kavada,Syudzi;Kurokava,Takasi;Yamaguti,Toru
标题:Kavada,Syudzi;Kurokava,Takasi;Yamaguti,Toru

专利信息

专利号:US-11851651-B2
优先权日:2017-06-19
标 题 :Automated methods for scalable, parallelized enzymatic biopolymer synthesis and modification using microfluidic devices
发明人：BANAL JAMES; BERLEANT JOSEPH DON; SHEPHERD TYSON; BATHE MARK
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Methods for the automated template-free synthesis of user-defined sequence controlled biopolymers using microfluidic devices are described. The methods facilitate simultaneous synthesis of up to thousands of uniquely addressed biopolymers from the controlled movement and combination of regents as fluid droplets using microfluidic and EWOD-based systems. In some forms, biopolymers including nucleic acids, peptides, carbohydrates, and lipids are synthesized from step-wise assembly of building blocks based on a user-defined sequence of droplet movements. In some forms, the methods synthesize uniquely addressed nucleic acids of up to 1,000 nucleotides in length. Methods for adding, removing and changing barcodes on biopolymers are also provided. Biopolymers synthesized according to the methods, and libraries and databases thereof are also described. Modified biopolymers, including chemically modified nucleotides and biopolymers conjugated to other molecules are described.