CAS: 57090-88-7; 1H-Imidazole-4-Carbonitrile

相似化合物

1072-84-0 3034-50-2 26832-08-6

4-(三氟甲基)-1H-咪唑置于ammonium Hydroxide体系中,化学反应 8.0H,以87%的收率获得产物1H-咪唑-4-甲腈
参考文献:A Convenient Procedure For The Preparation Of 4(5)-Cyanoimidazoles
标题:A Convenient Procedure For The Preparation Of 4(5)-Cyanoimidazoles
摘要:
DOI:10.1021/jo00366A037

专利信息

专利号:US-9303046-B2
优先权日:2012-08-07
标 题:Process for the preparation of heterocyclic ester derivatives
发明人：BONGARTZ JEAN-PIERRE ANDRÉ MARC; STAPPERS ALFRED ELISABETH; TELEHA CHRISTOPHER A; WEERTS KOEN JOHAN HERMAN; WILSON KENNETH J
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to a process for the preparation of heterocyclic ester derivatives of formula I n nwherein A 1 , SEM, and W 1 are as defined herein. Such compounds are useful as intermediates in the synthesis of derivatives useful as protein tyrosine kinase inhibitors, more particularly inhibitors of c-fms kinase.

专利号:WO-2010149360-A1
优先权日:2009-06-26
标题:Process for the preparation of benzimidazoles
发明人：HANSELMANN PAUL; WONG HEILAM; KLEGRAF ELLEN; ZARAGOZA DOERWALD FLORENCIO; DING ZUNLIANG; LONG JUN
权利人:LONZA AG; HANSELMANN PAUL; WONG HEILAM; KLEGRAF ELLEN; ZARAGOZA DOERWALD FLORENCIO; DING ZUNLIANG; LONG JUN
摘要:Substituted benzimidazoles of formula (I), wherein R 1 and R 2 independently are hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl and R 3 is cyano or carboxy, are prepared in a multistep synthesis starting from Î? -acyl-4-halo- anilines of formula (II), wherein R 1 and R 2 are as defined above and X is chlorine or bromine.

专利号:US-2013273461-A1
优先权日:2012-04-11
标题 :Synthesis of electrocatalysts using metal-organic framework materials

专利号:US-11718586-B2
优先权日:2019-11-08
标 题:Method for preparing dexmedetomidine
发明人：DIKER KHALID; GORINS GILLES; OZANNE-BEAUDENON AURÉLIE; GOLDSTEIN CORINNE
权利人:NORCHIM
摘要:The present invention relates to a method for preparing dexmedetomidine having the following formula (I): or a pharmaceutically acceptable salt and/or solvate thereof, comprising the following successive steps: a) asymmetric hydrogenation of a methylene derivative of the following formula (II): in order to obtain dexmedetomidine, and b) optionally salifying and/or solvating dexmedetomidine in order to obtain a pharmaceutically acceptable salt and/or solvate of dexmedetomidine, wherein the methylene derivative of formula (II) is prepared from a halide of the following formula (V), in which Hal 2 represents a halogen atom such as Br, and a cyanoimidazole of the following formula (VI). The present invention relates also to methods for preparing synthesis intermediates of dexmedetomidine from the halide of formula (V) and the cyanoimidazole of formula (VI), these synthesis intermediates being the methylene derivative of formula (II), an alcohol of the following formula (III), and a ketone of the following formula (IV).

专利号:CN-106061963-B
优先权日:2013-12-20
标题 :Heterocyclic modulators of lipid synthesis and combinations thereof

专利号:CN-116987036-A
优先权日:2023-08-04
标题:A kind of synthesis method of base-promoted 4-cyanoimidazole derivatives