CAS: 5589-96-8; 2-Bromo-2-Chloroacetic Acid

该化合物是一种卤化乙酸衍生物,其分子式为C2H2BrClO2,主要用作有机合成的中间体和化学研究的试剂;BCAA因其在核生殖替代和消化反应中的活性而受到重视,因此有助于制备更复杂的卤化化合物;其平衡的溴和氯分体有助于其改变分子结构的效力;该化合物由于其腐蚀性,通常在受控制的条件下处理;BCAAA还受到环境化学研究,以形成水处理过程中的消毒副产品.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号79-11-8 氯乙酸 | CAS号5278-95-5 二溴一氯乙酸 | CAS号20428-74-4 甲基溴氯乙酸酯 | CAS号79-11-8 氯乙酸

合成工艺路线路线简述

    二溴一氯乙酸置于水,铁粉体系中,化学反应生成 一溴一氯乙酸
    参考文献:Fe0还原卤代乙酸:对治疗和命运的影响.
    标题:Fe0还原卤代乙酸:对治疗和命运的影响.
    摘要:为了预测天然或工程系统中的卤乙酸(haas)的命运,需要有关这些化合物进行的反应类型,这些反应的速率以及形成的产物的信息.鉴于许多饮用水分配系统由无衬里的铸铁管组成,Haa与元素铁(fe0)的反应可能在确定这些系统中haa的命运方面发挥了作用.此外,零价铁可能被证明是从氯化饮用水和废水中去除haas的有效处理技术.因此,分批实验用于研究四种三卤代乙酸,三氯代乙酸(tcaa),三溴代乙酸(tbaa),氯代二溴代乙酸(cdbaa)和溴代二氯代乙酸(bdcaa)与fe0的反应.所有化合物都容易与fe0反应,产物形成和随后消失的研究表明反应通过顺序氢解进行的.溴优先于氯去除,而tbaa是唯一完全脱卤为乙酸的化合物.在含氯化合物中,与fe0反应的最终产物为一氯乙酸.卤素质量平衡为95-112%,碳质量平衡为62.6-112%.三卤代乙酸降解的拟一级反应速率常数如下:Bdcaa(10.6 +/-3
    DOI:10.1021/es001785B

    海关参考信息

    专利信息


    专利号:US-2012094919-A1
    优先权日:2009-03-16
    标题 :Use of tripeptides
    发明人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO
    权利人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO
    摘要:The present invention relates to the use of tripeptide derivatives for tightening, firming and/or moisturizing skin. Furthermore, the invention relates to a method for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue and/or proteoglycans by fibroblasts and/or keratinocytes such as in particular the synthesis of Hyaluronic acid and/or of the proteoglycans Decorin and/or Lumican.

    专利号:WO-9108220-A1
    优先权日:1989-12-01
    标 题:A method for the stepwise, controlled synthesis of chemical species, particularly peptides, coupled products obtained by the method and the use of these coupled products, e.g. as vaccines
    发明人:HOUEN GUNNAR; HOLM ARNE
    权利人:HOUEN GUNNAR; HOLM ARNE
    摘要:Chemical species, particularly peptides, are synthesized by a stepwise, controlled process, in which a proteinaceous substance such as a protein is used as the synthesis substrate. The products obtained by the process can be used e.g. as vaccines against various diseases and as matrix materials or carrier molecules.

    专利号:WO-0031134-A9
    优先权日:1998-11-20
    标题:Regulation of hair follicle morphogenesis based on beta-catenin
    发明人:GAT URI; DASGUPTA RAMANUJ; DEGENSTEIN LINDA; FUCHS ELAINE
    权利人:ARCH DEV CORP; GAT URI; DASGUPTA RAMANUJ; DEGENSTEIN LINDA; FUCHS ELAINE
    摘要:The present invention provides a method for inducing hair growth by providing beta-catenin activity to a skin cell. This may be achieved by providing a beta-catenin polypeptide, providing a beta-catenin agonist, providing a polynucleotide encoding a beta-catenin polypeptide, enhancing the de novo synthesis of beta-catenin, increasing the stability or decreasing the degradation of beta-catenin polypeptides.

    专利号:EP-1239813-B1
    优先权日:1999-12-23
    标题:Extract of blue-green alga spirulina and the use thereof in cosmetic skin-care and body care agents
    发明人:SCHLOTMANN KORDULA; WALDMANN-LAUE MARIANNE; JASSOY CLAUDIA; KAETEN MELANIE; KOEHLER EVA-MARIA; PULZ OTTO; KURTH ELKE
    权利人:HENKEL KGAA
    摘要:The invention relates to an aqueous or aqueous-alcoholic extract of the blue-green algal taxon Spirulina, characterized in that it contains at least 10 wt. % magnesium in relation to the dry weight of said extract. The inventive blue-green alga extract is an efficacious component for stimulating intracellular synthesis of ATP and matrix proteins and differentiation of keratinozytes. The blue-green alga extract is used in topical preparations for cleaning and cosmetic care of the skin and hair, in addition to the production of agents for dermatological treatment of the skin.

    专利号:US-6511832-B1
    优先权日:1999-10-06
    标题:In vitro synthesis of capped and polyadenylated mRNAs using baculovirus RNA polymerase
    发明人:GUARINO LINDA A; DONG WEN; JIN JIANPING
    权利人:TEXAS A & M UNIV SYS
    摘要:The present invention relates to the use of baculovirus RNA polymerase for the production of capped and polyadenylated transcripts in vivo and especially in vitro. More particularly, the purified RNA polymerase of the present invention may be used to produce in vitro transcription and/or in vitro transcription/translation kits.

    专利号:WO-2005079742-A1
    优先权日:2004-02-19
    标 题:Cosmetic and/or dermatological agent for increasing the endogenous lipid content of the skin
    发明人:VEEGER MARCEL; KLOTZ ANDREAS; ZUR MUEHLEN ANNETTE; THOERNER BRIGITTE
    权利人:STOCKHAUSEN CHEM FAB GMBH; VEEGER MARCEL; KLOTZ ANDREAS; ZUR MUEHLEN ANNETTE; THOERNER BRIGITTE
    摘要:The invention relates to the use of at least one active ingredient that is selected from the water-soluble groups: (a) allantoin; (b) salts and/or esters of gluconic acid and/or aspartic acid; (c) precursors of creatine, creatine and creatinine and their derivatives; (d) glycyrrhetinic acid or the salts and/or esters thereof; (e) D-panthenol and/or at least one active ingredient that is selected from the oil-soluble groups: (f) vitamin E acetate; (g) cholesterol; (h) derivatives of glycyrrhetinic acid, in so far as they are soluble in the oils and fats that are conventionally used in the cosmetic industry; (i) vegetable oils and fats; (j) non-saponifiable fractions of vegetable fats. Said active ingredients are used alone or in combination with one or more active ingredients from the groups (a) to (j) to produce a cosmetic and/or dermatological agent for stimulating the endogenous synthesis of barrier substances, in particular for increasing the endogenous lipid content of the skin.
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    合成参考文献


    摘要:Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 7-4, 7-5, 8-12 (1990)
    摘要:
    摘要:Franke C et al; Chemosphere 29: 1501-14 (1994)
    摘要:NTP/NIEHS; Short Term Reproductive and Developmental Toxicity of Bromochloroacetic Acid (CAS No. 5589-96-8) Administered in the Drinking Water to Sprague-Dawley Rats NTP Study Number: RDGT96001. NTIS#: PB98-172414 (August 1998). Abstract
    摘要:NTP/NIEHS; TR-549 Toxicology and Carcinogenesis Studies of Bromochloroacetic Acid (CAS No. 5589-96-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) (Draft abstract).
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