CAS: 54631-81-1; Boc-Hyp(Bzl)-Oh

上下游产品

(2S,4S)-1-tert-butyl 2-methyl 4-(benzyloxy)pyrrolidine-1,2-dicarboxylate (2S,4S)-2-benzyl 1-tert-butyl 4-(benzyloxy)pyrrolidine-1,2-dicarboxylate benzyl bromide N-tert-butoxycarbonyl-L-cis-4-hydroxyproline4(S)-Benzyloxy-N-tert-butyl-1-(tert-butyloxycarbonyl) pyrrolidine-2(S)-carboxamide Thr-Homotyr-4-OH-Pro-Thr-α-N-(°Ctyloxybenzpyl)-Orn Thr-Thr-Homotyr-Pro-Thr-α-N-(°Ctyloxybenzoyl)-Orn Pro-Thr-Tyr-4-OH-Pro-Thr-α-N-(°Ctyloxybenzoyl)-Orn

📜N-Boc-反式-4-羟基-L-脯氨酸甲酯置于水,Sodium Hydride,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,Hexanes,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 2.17H,反应生成 N-叔丁氧羰基-O-苄基-反式-4-羟基-L-脯氨酸
参考文献: Pyrrolotriazinone Derivatives As Pi3K Inhibitors[fr] Dérivés De Pyrrolotriazinone En Tant Qu'Inhibiteurs De Pi3K
标题: Pyrrolotriazinone Derivatives As Pi3K Inhibitors[fr] Dérivés De Pyrrolotriazinone En Tant Qu'Inhibiteurs De Pi3K
摘要:披露了具有公式(I)化学结构的新型吡咯三嗪酮衍生物;以及它们的制备方法,包含它们的药物组合物以及它们作为磷脂酰肌醇3-激酶(pi3Ks)抑制剂在治疗中的用途.

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.