CAS: 53215-95-5; N-(Trimethylsilylmethyl)Benzylamine

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CAS号100-46-9 苄胺 | CAS号2344-80-1 氯甲基三甲基硅烷 | CAS号18243-41-9 溴乙基三甲基硅烷 | CAS号59006-07-4 4-methylbenzene... | CAS号109202-53-1 N-benzyl-1-phen... | CAS号5747-92-2 1-苄基吡咯烷-3-甲酸乙酯 | CAS号93102-05-7 N-(甲氧甲基)-N-(三甲基... | CAS号6343-54-0 N-苯甲基甲酰胺 | CAS号57402-97-8 1-phenyl-N-(tri... | CAS号101767-83-3 1-苄基-3-苯磺酰基吡咯烷 | CAS号13657-16-4 3-苄基恶唑烷 | CAS号101046-34-8 1-苄基-2,5-二氢吡咯-3-甲酸甲酯 | CAS号17012-21-4 N-苄基-3-吡咯烷甲酸甲酯

苄胺,氯甲基三甲基硅烷置于potassium Carbonate体系中,用 乙腈 作为反应溶剂,化学反应 4.0H,以80%的收率获得产物n-[(三甲基硅)甲基]苄胺
参考文献:Non-Stabilized Azomethine Ylides In [3 + 2] Cycloadditions. Pyrrolidinylfuranones From (5S)-5-Menthyloxy-4-Vinylfuran-2(5H)-One
标题:Non-Stabilized Azomethine Ylides In [3 + 2] Cycloadditions. Pyrrolidinylfuranones From (5S)-5-Menthyloxy-4-Vinylfuran-2(5H)-One
摘要:用氟化锂在乙腈中超声 N-苄基-N-甲氧基甲基(三甲基硅甲基)胺 9A-C 与 4-乙烯基呋喃酮 2 和 6 发生化学选择性 1,3-二极环加成反应,得到吡咯烷基呋喃酮 10,11A-C 和 12A-C.通过 X 射线分析和与相关的环氧丙烷基呋喃酮 13 的质子核磁共振数据比较,确定了其立体化学性质.
DOI:10.1039/a803693D

专利信息

专利号:US-7230119-B2
优先权日:2004-08-25
标 题 :Process for the preparation of substituted pyrrolidine derivatives and intermediates
发明人：CHAND POORAN; EL-KATTAN YAHYA; KOTIAN PRAVIN L
权利人:BIOCRYST PHARM INC
摘要:Two syntheses are provided; one for the preparation of (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol, and other for the preparation of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol. (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is prepared using the achiral ylide prepared from benzylamine instead of phenethylamine (Scheme 3) which provides a crystalline intermediate. The synthesis of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is achieved from (S)-diethylmalate as described in Scheme 4. A process for preparing camphor sultam is also provided.

专利号:WO-2005033076-A1
优先权日:2003-10-03
标题 :Method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
发明人：TYLER PETER CHARLES; CLINCH KEITH
权利人:IND RES LTD; TYLER PETER CHARLES; CLINCH KEITH
摘要:This invention relates to a method of preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, a key intermediate compound for the synthesis of certain inhibitor compounds, including the step of enzyme catalysed enantioselective esterification of an hydroxy group of an hydroxypyrrolidine. The invention further relates to a method for preparing (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine, which is the enantiomer of (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine.

专利号:CN-109053526-A
优先权日:2018-08-13
标 题 :A chemical synthesis method of (3R,4S)-4-methylpyrrolidin-3-ylcarbamate tert-butyl hydrochloride

专利号:CN-108912032-A
优先权日:2018-08-13
标题:A chemical synthesis method of (3S, 4R)-4-methylpyrrolidin-3-ylaminomethanol tert-butyl ester hydrochloride