CAS: 50743-17-4; 4-Oxo-4H-Chromene-3-Carbonitrile
该化合物是一种多用途有机化合物,以其独特的蓝色和强烈的紫外线吸收特性而闻名. 它被广泛用于染料,颜料和光色材料的合成. 它提供了高纯度和稳定性,使它适用于需要精确颜色匹配和紫外线保护的应用. 它独特的化学结构为高效反应提供了便利,提高了化学过程的生产力.
- 英文名称4-Oxo-4H-Chromene-3-Carbonitrile
- 中文名称3-氰基色酮
- IUPAC名称4-oxo-4H-chromene-3-carbonitrile
- 其它别名3-Cyan°Chromone; 4-Oxo-4H-1-benzopyran-3-carbonitrile; 4-Oxo-4H-benzopyran-3-carbonitrile; 4-Oxo-4H-chromene-3-carbonitrile
- CAS编号50743-17-4
- MFCD编号:MFCD00052604
- EINECS号:677-859-9
- 分子式:C10H5NO2分子量:171.15
- 产品CID: 1495784
- 产品分类有机原料→分子砌块→芳杂环类化合物→色原酮类化合物
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: SFWNPLLGXKJESA-UHFFFAOYSA-N
- InChI=1S/C10H5NO2/c11-5-7-6-13-9-4-2-1-3-8(9)10(7)12/h1-4,6H
- 计算化学: 氢键受体数3.0氢键供体数0可旋转键数0
物理性质
- 熔点174-176 °C
- 沸点278.3±40.0 °C at 760 mmHg
- 闪点119.5 °C
- 密度1.34g/cm3
- PSA:54.0
- LogP:1.66468
- 折射率1.621
- 蒸汽压0.0043 mmHg at 25 °C
- 敏感性如果遵照规格使用和储存则不会分解，未有已知危险反应
- 外观形态白色至黄色至绿色粉末至晶体
- 储存条件密封, 常温干燥保存
- 产品应用该化合物用于下列合成:2-氨基铬酮-3-碳BOXAMID 3-氨基-4 H-CHROMENO[3,4-D]ISOXAZOL-4-1-1-1-3-(二甲基甲基甲基)CHROMAN-2,4-二ONE功能化的小说螺旋苯甲酸酯 6 H-BIS--苯丙诺[2,3-B:3>-B;3,4.-E]丁-8(8)°C和3-(2)-羟基苯基)-5 H-[1-苯并[4,3-B]
MSDS等安全信息
- GHS象形图
- GHS符号GHS06;
注释: Skull and crossbones - 危险类别急性毒性 类别4(吸入)
急性毒性 类别4(经皮)
急性毒性 类别3(经口)
急性毒性 类别3(吸入)
急性毒性 类别3(经皮)
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2
特定目标器官毒性 - 单次接触 类别3
严重眼刺激 类别2A - 警示词Danger(危险)
- 危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H301 |吞咽会中毒.
H331 |吸入会中毒.
H311 |皮肤接触会中毒.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H335 |可能引起呼吸道刺激. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
- 危险等级6.1
- UN编号3439.0
- 危险品标志Xn,Xi,T
- 风险等级Irritant
- 包装等级Ⅲ
- 安全声明36/37/39-26-36-45-36/37-24/25
- 危险类别码36/37/38-20/21/22-25-20/21
- WGK Germany3
欧盟法规
ECHA物质C&L通报上下游产品
CAS号17422-74-1 色酮-3-甲醛 | CAS号118-93-4 邻羟基苯乙酮 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号1846-78-2 2-ox°Chromene-3... | CAS号873-67-6 benzonitrile oxide | CAS号1224712-21-3 4-ox°Chroman-3-... | CAS号25575-32-0 chlorosulfinylo... | CAS号23462-75-1 四氢-2H-吡喃-3-酮 | CAS号39079-62-4 色酮-3-甲酸 | CAS号6537-46-8 1-氮杂呫吨酮 | CAS号61424-76-8 2-氨基-3-甲酰色酮 | CAS号73262-05-2 2-[(2-hydroxybe... | CAS号83989-73-5 3-chloro-2-meth... | CAS号73262-21-2 2-(4-oxo-4H-[1]... | CAS号67867-47-4 3-乙酰基-2-甲基-5H-[... | CAS号1224096-89-2 1,2-dimethyl-5-... | CAS号69-72-7 水杨酸 | CAS号61424-82-6 2-amino-3-(hydr...合成工艺路线路线简述
📜4-Oxochroman-3-Carbonitrile置于2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 1,4-二氧六环 作为反应溶剂,以0.042 G的收率获得产物色酮-3-甲腈
参考文献:Khmds Enhanced Smi2-Mediated Reformatsky Type α-Cyanation
标题:Khmds Enhanced Smi2-Mediated Reformatsky Type α-Cyanation
摘要:A Novel Combination Of Smi2,Khmds,And Tscn Can Be Utilized To Introduce A Cyano Group Into Structurally Diverse And Highly Sensitive 2-Alkyl-Chroman-4-Ones. Subsequent Oxidation Allows The Formed 2-Alkyl-3-Cyanochromones To Be Isolated In Yields Ranging From 49 To 77%. In Addition,Alpha-Bromoketones And Esters Were Found To Undergo Equally Effective Alpha-Cyanation.
DOI:10.1021/ol100424Y
海关参考信息
- 2902200000-苯
2926909090-其他腈基化合物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11471537-B2
优先权日:2017-04-05
标题 :Oligomer extended insulin-Fc conjugates
发明人：MOELLER TAGMOSE TINA; MADSEN PETER; KJELDSEN THOMAS BOERGLUM; PRIDAL LONE; DE MARIA LEONARDO; LIN ZHAOSHENG; Wan zhe; ZHANG YUANYUAN; LYKKE LENNART; MUENZEL MARTIN WERNER BORCHSENIUS; KODRA JANOS TIBOR
权利人:NOVO NORDISK AS
摘要:This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to novel Fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Shaabani, A.; Sarvary, A.; Shaabani, S., Science of Synthesis: Multicomponent Reactions, (2013) 2, 95.
参考文献:10.1007/s11172-021-3183-6
摘要:Shatokhin SS, Tuskaev VA, Gagieva SC, Oganesyan ÉT. Synthesis of heterocyclic analogs of isoflavone and homoisoflavone based on 3-formylchromone. Russian Chemical Bulletin. 2021 Jun;70(6):1011–45. doi: 10.1007/s11172-021-3183-6.
📝 需求与反馈
尽可能描述清楚需求与问题信息
