CAS: 496-76-4; Dihydropyrimidine-2,4,5(3H)-Trione
- 英文名称Dihydropyrimidine-2,4,5(3H)-Trione
- 中文名称二氢嘧啶-2,4,5(3H)-三酮
- IUPAC名称1,3-diazinane-2,4,5-trione
- 其它别名氟尿嘧啶杂质b(Ep; Fluorouracil Impurity 2(Fluorouracil Ep Impurity B)
- CAS编号496-76-4
- MFCD编号:MFCD00082987
- EINECS号:207-829-9
- FDA UNII编号:438WJI1S49
- 分子式:C4H4N2O3分子量:128.09
- 产品CID: 1483126
- 产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物
相似化合物
504-07-4 50-71-5 63041-13-4物理性质
- 熔点>300 °C
- 沸点534.5±53.0 °C at 760 mmHg
- 闪点277.0±30.9 °C
- 密度1.8±0.1 g/cm3
- pKa:8.25±0.20(预测)
- PSA:75.27
- LogP:-1.6051
- 折射率1.719
- 蒸汽压0.0±1.5 mmHg at 25°C
- 溶解性Soluble In DMSO (Sparingly), Methanol (Sparingly).
- 敏感性按规格使用和贮存，不会发生分解，避免与氧化物接触
- 外观形态淡黄色结晶
- 储存条件2-8°C
- 产品应用该化合物用于组织造皮肤中的氧化性DNA损害生物标志.它作为极光体的对抗者,在LACTOBACILLUS 病例的生长中起到抗体作用.
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
📜尿嘧啶 反应生成 5-羟基尿嘧啶
参考文献:Itahara,Toshio;Ide,Naoko,Med.,Biochem. And Chem. Aspects Free Radicals: Proc. 4Th Bienn. Gen. Mee+
标题:Itahara,Toshio;Ide,Naoko,Med.,Biochem. And Chem. Aspects Free Radicals: Proc. 4Th Bienn. Gen. Mee+
海关参考信息
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2912120000-乙醛
2914110000-丙酮
2924199090-其他无环酰胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6765089-B1
优先权日:1997-09-24
标 题 :Protecting and linking groups for organic synthesis on solid supports
发明人：TOTH ISTVAN; DEKANY GYULA; KELLAM BARRY
权利人:ALCHEMIA PTY LTD
摘要:This invention relates to methods for synthesis of organic compounds, and in particular to compounds useful as protecting and linking groups for use in the synthesis of peptides, oligosaccharides, glycopeptides and glycolipids. The invention provides protecting and linking groups that are useful in both solid phase and solution synthesis, and are particularly applicable to combinatorial synthesis.
专利号:JP-2000281611-A
优先权日:1999-03-30
标 题 :Synthesis of phenolic compound having protected hydroxy group, and radioactive ray-sensitive composition by using the same
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
[参考文献]: Aditi Das, Et Al. Identification Of A Zinc Finger Domain In The Human Neil2 (Nei-Like-2) Protein. J Biol Chem. 2004 Nov 5;279(45):47132-8.[参考文献]: Gunn A Hildrestrand, Et Al. Modulation Of Dna Glycosylase Activities In Mesenchymal Stem Cells. Exp Cell Res. 2009 Sep 10;315(15):2558-67.
[参考文献]: Jason L Parsons, Et Al. Dna Polymerase Delta-Dependent Repair Of Dna Single Strand Breaks Containing 3'-End Proximal Lesions. Nucleic Acids Res. 2007;35(4):1054-63.
[参考文献]: Jason L Parsons, Et Al. Neil1 Is The Major Dna Glycosylase That Processes 5-Hydroxyuracil In The Proximity Of A Dna Single-Strand Break. Biochemistry. 2007 Apr 3;46(13):4158-63.
[参考文献]: Mayumi Matsubara, Et Al. Mutational Analysis Of The Damage-Recognition And Catalytic Mechanism Of Human Smug1 Dna Glycosylase. Nucleic Acids Res. 2004 Oct 5;32(17):5291-302.
合成参考文献
参考文献:10.1016/s0304-3835(98)00170-0
摘要:Foksinski M, Jaruga P, Makarewicz R, Olinski R. Oxidative DNA base damage in cancerous tissues of patients undergoing brachytherapy. Cancer Lett. 1998 Oct 23;132(1-2):169–73. doi: 10.1016/s0304-3835(98)00170-0.
参考文献:10.1083/jcb.4.6.793
摘要:SCHREIBER RW, DUNCAN RE. A cytological analysis of the antimetabolite activity of 5-hydroxyuracil in Vicia faba roots. J Biophys Biochem Cytol. 1958 Nov 25;4(6):793–806.
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