CAS: 3819-00-9; 1-(10-(3-(4-(2-Hydroxyethyl)Piperidin-1-yl)Propyl)-10H-Phenothiazin-2-yl)Ethan-1-One

📜4-N-(6-Chloro-2-Methoxyacridin-9-yl)-1-N,1-N-Diethylpentane-1,4-Diamine;Hydron;Dichloride,育亨酸一水,甲萘醌,Hydron;2-[4-[3-[2-(Trifluoromethyl)Phenothiazin-10-Yl]Propyl]Piperazin-1-Yl]Ethanol;Dichloride,Trifluoroperazine Dihydrochloride 以piperacetazine (Cas#3819-00-9) Was Obtained Directly From The Prestwick Small Molecule Library Resource的收率获得产物乙酰哌普嗪
参考文献:Identification Of Structurally Similar Small Molecules That Enhance Therapeutic Exon Skipping
标题:Identification Of Structurally Similar Small Molecules That Enhance Therapeutic Exon Skipping
摘要:本发明涉及一种增强感兴趣的前mrna的外显子跳跃的方法,包括将前mrna与有效量的化合物接触,例如perphenazine,Flupentixol Dihcl,Zuclopenthixol或corynanthine Hcl,或具有类似2-D结构和活性水平的化合物,或化合物的药学上可接受的盐,水合物,溶剂化物或异构体,以及选择性针对前mrna中剪接序列的反义寡核苷酸(如果需要).还公开了治疗杜氏肌肉萎缩症(dmd)的方法.

专利信息

专利号:CN-101535336-A
优先权日:2006-11-10
标题 :Synthesis of Phthalamide and Its Dimer

专利号:US-9617230-B2
优先权日:2014-12-22
标题:Creatine prodrugs, compositions and methods of use thereof
发明人：BRUBAKER WILLIAM F
权利人:FARMINGTON PHARMA DEV
摘要:The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.

专利号:US-11021501-B2
优先权日:2015-03-30
标题:Creatine phosphate analog prodrugs, compositions and methods of use thereof
发明人：BRUBAKER WILLIAM F
权利人:FARMINGTON PHARMA DEV
摘要:The invention describes membrane permeable creatine phosphate analog prodrugs, pharmaceutical compositions comprising membrane permeable creatine phosphate analog prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine phosphate analog prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine phosphate analog prodrugs or pharmaceutical compositions thereof.

专利号:SK-156996-A3
优先权日:1994-06-08
标 题 :A molecule of isolated dna for the synthesis of antipathogenic substances, vectors and hosts comprising this molecule and its use

专利号:US-9486471-B2
优先权日:2012-03-28
标题:Combination therapy for the treatment of cancer
发明人：BHATIA MICKIE; SACHLOS ELEFTHERIOS
权利人:UNIV MCMASTER
摘要:Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a DNA synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. The methods and compositions are useful for the treatment of cancers such as acute myeloid leukemia.

专利号:CN-101627049-B
优先权日:2006-11-10
标题 :Synthesis of phthalamides