CAS: 374633-31-5; 2-Bromo-3-Nitro-6-Methylpyridine

该化合物是一种卤代硝基丙烯衍生物,在有机合成和制药研究方面非常有用,其溴和硝基功能组使其成为核生殖替代反应的多用途中间体,有助于构建复杂的异环环框架.6级的甲基组别增强消毒和电子特性,影响交叉和循环反应中的回动.该化合物在药用化学中对于生物活性分子的开发,包括潜在的农用化学品和药品的开发特别宝贵.高纯度能能确保合成应用的一贯性.需要妥善处理,因为它具有再活性,并且对光和湿度具有潜在敏感性.

英文名称2-Bromo-3-Nitro-6-Methylpyridine
中文名称2-溴-3-硝基-6-甲基吡啶
IUPAC名称2-bromo-6-methyl-3-nitropyridine
其它别名2-溴-6-甲基-3-硝基吡啶; 2-Bromo-6-Methyl-3-Nitropyridine
CAS编号374633-31-5
MFCD编号:MFCD03095212
EINECS号:966-046-7
分子式:C6H5BrN2O2
分子量:217.02
产品CID: 1384632
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: IHHLJCDGOSZFTB-UHFFFAOYSA-N
InChI=1S/C6H5BrN2O2/c1-4-2-3-5(9(10)11)6(7)8-4/h2-3H,1H3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数1.0

相似化合物

126325-53-9 19755-53-4 55304-80-8

MSDS等安全信息

GHS符号GHS07
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级IRRITANT
危险品标志Xi

欧盟法规

C&L通报

上下游产品

6-methyl-3-nitrohydropyridin-2-one 2-methyl-8,8-diphenyl-6,7,8,9-tetrahydro-dipyrido[1,2-a;3',2'-d]imidazole

合成工艺路线路线简述

2-羟基-3-硝基-6-甲基吡啶置于溴,三溴化磷体系中,化学反应生成2-溴-6-甲基-3-硝基吡啶,2,5-Dibromo-6-Methyl-3-Nitropyridine
参考文献:Bromination Products Of Nitropyridine
标题:Bromination Products Of Nitropyridine
摘要:
Doi:10.1021/ja01627A078

海关参考信息

2933310010-吡啶
2904209090-其他仅含硝基或亚硝基衍生物
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÃ‰ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÃ‰ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:EP-2173747-B1
优先权日:2007-06-26
标题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS
权利人:SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-2010261909-A1
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:WO-2009000413-A1
优先权日:2007-06-26
标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:CA-2693142-A1
优先权日:2007-06-26
标题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles

专利号:AU-2008267444-A1
优先权日:2007-06-26
标题 :A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles