CAS: 26400-33-9; 2-[[2-[3-(Furan-2-yl)Prop-2-Enoylamino]Acetyl]Amino]-4-Methylpentanamide
该化合物是一种合成三环化物,由苯丙烯(Fa), glycine(Gly)和leucine(Leu)组成,并附有C-终点氨化物修改法,主要用于生化和制药研究,因其结构稳定性和潜在的生物活性特性.C-终点的粘合物组增强了对酶降解的抗药性,提高了其在peptide稳定性研究中的效用.其定义明确的序列使其适合用于调查基苯酶相互作用,peptide合成优化和结构-活动关系研究.Fa-Gly-Leu-NH2 通常被用作开发更复杂的聚苯基化合物的参考标准或中间标准.
- 英文名称2-[[2-[3-(Furan-2-yl)Prop-2-Enoylamino]Acetyl]Amino]-4-Methylpentanamide
- 中文名称N-(3-[2-呋喃]丙烯)甘氨酸亮酰胺
- IUPAC名称(S,E)-2-(2-(3-(furan-2-yl)acrylamido)acetamido)-4-methylpentanamide
- 其它别名2-Furanacrylamide,N-[[(1-carbamoyl-3-methylbutyl)carbamoyl]methyl]-, L- (8CI); L-Leucinamide,N-[3-(2-furanyl)-1-oxo-2-propenyl]glycyl- (9CI); Leucinamide,N-[3-(2-furyl)acryloyl]glycyl-, L- (8CI); 3-(2-Furylacryloyl)glycyl-L-leucineamide; FAGLA; Furacryloylglycyl-L-leucinamide; Furylacryloylglycyl-L-leucinamide; N-3-(2-Furyl)acryloylglycyl-L-leucinaminde; N-Furylacryloylglycyl-L-leucinamide
- CAS编号26400-33-9
- MFCD编号:MFCD00077117
- FDA UNII编号:2Z67P4PFX8
- 分子式:C15H21N3O4分子量:307.34
- 产品CID: 1238670
- 产品分类生物化工 → 氨基酸及其衍生物 → 甘氨酸类衍生物
物理性质
MSDS等安全信息
上下游产品
CAS号124882-74-2 反式-N-(2-糠叉基乙酰基)甘氨酸 | CAS号687-51-4 亮氨酰胺合成工艺路线路线简述
- 合成目标产物 Fa-Gly-Leu-Nh2 主要起始原料 Fa-Gly-Oh And L-Leucinamide Hydrochloride
- (文献来源)合成步骤主要原料 Fa-Gly-Oh 和 L-Leucinamide Hydrochloride
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7192730-B2
优先权日:1996-12-23
标 题:Thermostable proteolytic enzymes and uses thereof in peptide and protein synthesis
发明人：YOUNG DAVID MICHAEL
权利人:UNIV FLORIDA
摘要:The subject invention pertains to new thermostable enzymes and the use of these enzymes both in proteolysis as well as protein and polypeptide synthesis. The subject invention further concerns polynucleotide sequences which encode the enzymes of the subject invention.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Yokota S, Ohtsuka H, Noguchi H. Monoclonal antibodies against Pseudomonas aeruginosa elastase: a neutralizing antibody which recognizes a conformational epitope related to an active site of elastase. Eur J Biochem. 1992 Jun 1;206(2):587-93.
合成参考文献
参考文献:10.1016/j.pep.2005.07.023
摘要:Inouye K, Minoda M, Takita T, Sakurama H, Hashida Y, Kusano M, Yasukawa K. Extracellular production of recombinant thermolysin expressed in Escherichia coli, and its purification and enzymatic characterization. Protein Expression and Purification. 2006 Apr;46(2):248–55. doi: 10.1016/j.pep.2005.07.023.
参考文献:10.1007/s10930-004-5225-y
摘要:Zabolotskaya MV, Demidyuk IV, Akimkina TV, Kostrov SV. A novel neutral protease from Thermoactinomyces species 27a: sequencing of the gene, purification, and characterization of the enzyme. Protein J. 2004 Oct;23(7):483–92. doi: 10.1007/s10930-004-5225-y.
参考文献:10.1016/j.pep.2005.12.005
摘要:Demidyuk IV, Kalashnikov AE, Gromova TY, Gasanov EV, Safina DR, Zabolotskaya MV, Rudenskaya GN, Kostrov SV. Cloning, sequencing, expression, and characterization of protealysin, a novel neutral proteinase from Serratia proteamaculans representing a new group of thermolysin-like proteases with short N-terminal region of precursor. Protein Expression and Purification. 2006 Jun;47(2):551–61. doi: 10.1016/j.pep.2005.12.005.
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