CAS: 24589-77-3; 4-Hydrazinylbenzoic Acid Hydrochloride

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对氨基苯甲酸置于盐酸,Sodium Nitrite,硫酸体系中,用 水 用作溶剂,化学反应 12.0H,以91%的收率获得4-羧基苯肼盐酸盐
参考文献:4-肼基苯甲酸盐酸盐的合成,晶体结构和非共价相互作用.
标题:4-肼基苯甲酸盐酸盐的合成,晶体结构和非共价相互作用.
摘要:摘要 合成了化合物4-肼基苯甲酸盐酸盐(4-Hba),C7H9O2.cl,并通过ft-Ir光谱和x射线衍射对其进行了表征.该化合物在三斜晶系中结晶为无色针状物,空间群 Pˉ1 (Z = 2),晶胞参数 A = 3.7176 (4) A,B = 5.9133 (4) A,C = 19.3631 (13) A,α = 87.841 (6),β = 88.924 (6),γ = 80.203 (6),V = 419.13 (6) A3.组分离子通过 O-H⋯o,N-H⋯n 和 N-H⋯cl 氢键的组合连接形成复杂的三维骨架结构,其中每个阳离子通过 O 连接到其他两个阳离子-h⋯o 和 N-h⋯n 氢键,以及五个不同的阴离子,而每个阴离子接受来自五个不同阳离子的氢键.
Doi:10.1016/j.Molstruc.2019.127154

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-2019152896-A1
优先权日:2016-07-27
标题 :Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts

专利号:US-6506701-B1
优先权日:1996-05-03
标题:Rapid purification by polymer supported quench
发明人：BOLTON GARY L; BOOTH RICHARD J; CRESWELL MARK W; HODGES JOHN C; WARMUS JOSEPH S; WILSON MICHAEL W
权利人:WARNER LAMBERT CO
摘要:Novel polymer-supported quenching reagents of Formula I,whereinP is a polymer of low chemical reactivity which is soluble or insoluble;Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; andL is one or more chemically robust linkers that join P and Q;are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

专利号:CN-107663161-B
优先权日:2016-07-27
标题:A kind of continuous flow synthesis process of phenylhydrazine salt and substituted phenylhydrazine salt

专利号:CN-107793362-A
优先权日:2016-08-30
标题:Synthesis and application of a kind of phenylpyridazinone derivatives