间二(三氟甲基)苯胺置于三乙烯二胺,三光气体系中,用 二氯甲烷,甲苯 用作溶剂,化学反应 16.0H,反应生成3,5-双(三氟甲基)苯基异硫氰酯 参考文献:Design,Synthesis And Biological Evaluation Of Thiourea And Nicotinamide-Containing Sorafenib Analogs As Antitumor Agents 标题:Design,Synthesis And Biological Evaluation Of Thiourea And Nicotinamide-Containing Sorafenib Analogs As Antitumor Agents 摘要:硫脲和烟酰胺含量比索拉非尼更好的抗增殖和抗血管生成活性的类索拉非尼类似物已经被设计和合成. Doi:10.1039/c4Md00536H
专利号:US-10100060-B2 优先权日:2016-06-16 标题:Asymmetric synthesis of funapide 发明人:BEN-DAVID RONEN; CHEN JIAN; CHRISTIE MICHAEL A; DIMITRI MINA GADELRAB; GERSHON GRACIELA NOEMI; HE LINLI; LANDMESSER NELSON G; LEVY DANIEL V; MIZRAHI OREL YOSEF; MUDIPALLI PARTHA S; REESE HARLAN F; SCLAFANI JOSEPH A; WANG YI 权利人:XENON PHARMACEUTICALS INC 摘要:This invention is directed to asymmetric synthesis of funapide, which is useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
专利号:US-8084641-B2 优先权日:2005-10-11 标 题:Organocataslysts and methods of use in chemical synthesis 发明人:WANG WEI 权利人:WANG WEI; STC UNM 摘要:The present invention is directed to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use.
专利号:US-10385004-B2 优先权日:2015-02-13 标 题:Process and intermediates for the preparation of NEP inhibitors 发明人:MARTIN BENJAMIN; MANDRELLI FRANCESCA; VENTURONI FRANCESCO 权利人:NOVARTIS AG 摘要:The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.
专利号:CN-115515998-A 优先权日:2020-05-06 标题 :Synthesis of Polyurethanes by Chain Growth Copolymerization
专利号:CN-110922349-B 优先权日:2019-11-29 标题:Synthesis of anti-tumor compound and application of anti-tumor compound in multiple myeloma
专利号:CN-115515998-B 优先权日:2020-05-06 标 题:Synthesis of polyurethanes by chain growth copolymerization
参考标题:Eco-Friendly Construction Of Spiroquinazolin-2-(Thi)Ones And Quinolin-(Thio)Ureas Via Fe(Iii)-Catalyzed Multi-Component Domino Double [4 + 2] Annulations 作者:Zhentao Pan,Shuaijun Shi,Xuancheng Yang,Xuqiong Xiao,Wangqin Zhang,Shiliang Wang,Yongmin Ma 摘要:An Unprecedented Eco-Friendly Multi-Component Domino Approach For The Synthesis Of Spiroquinazolin-2-(Thi)Ones And Quinolin-(Thio)Ureas Via Fe(III)-Catalyzed Domino Double [4 + 2] Cycloadditions Is Described.
合成参考文献
摘要:Ayad, T.; Pirat, J.-L.; Virieux, D., Science of Synthesis Knowledge Updates, (2022) 1, 354. 摘要:Ayad, T.; Pirat, J.-L.; Virieux, D., Science of Synthesis Knowledge Updates, (2022) 1, 335.