CAS: 20290-09-9; Morphine 3-β-D-Glucuronide
- 英文名称Morphine 3-β-D-Glucuronide
- 中文名称吗啡-3-Β-D-葡糖苷酸
- IUPAC名称(2S,3S,4S,5R,6S)-6-[[(4R,4aR,7S,7aR,12bS)-7-hydroxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
- 其它别名M-3-G HYDRATE; MORPHINE-3-BETA-D-GLUCURONIDE; MORPHINE-3-BETA-D-GLUCURONIDE HYDRATE; MORPHINE-3-GLUCURONIDE; morphine-3-B-D-glucuronide*methanol solution; morphine-3-B-D-glucuronide--dea*schedule ii item; MORPHINE-3-B-D-GLUCURONIDE MAJOR METABOL ITE OF M; (5a,6a)-7,8-Didehydro-4,5-epoxy-6-hydroxy-17-methylmorphinan-3-yl b-d-Glucopyranosiduronic Acid
- CAS编号20290-09-9
- MFCD编号:MFCD02259003
- EINECS号:621-410-1
- FDA UNII编号:O27Z9CH39A
- 分子式:C23H27NO9分子量:461.46
- 产品CID: 1029958
- 产品分类有机原料 → 生物碱及其衍生物 → 吗啡烷
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(经口)
特定目标器官毒性 - 单次接触 类别3
皮肤致敏 类别1 - 警示词Warning(警告)
- 危险描述H302 |吞咽有害.
H336 |可能引起嗜睡或头晕.
H317 |可能引起皮肤过敏反应. - 防范说明P210-P233-P280-P301+P310-P303+P361+P353-P304+P340+P311
- UN编号UN 1230 3/PG 2
- 危险品标志Xn,T,F
- 安全声明36-45-53-36/37-16-7
- 危险类别码23/25-36/38-36-20/21-61-43-22-39/23/24/25-23/24/25-10-11
- WGK Germany3
欧盟法规
C&L通报上下游产品
CAS号57-27-2 吗啡 | CAS号21085-72-3 乙酰溴-Alpha-D-葡萄糖酮酸甲基酯 | CAS号2616-64-0 UDP葡萄糖醛酸 | CAS号78132-48-6 尿苷-5’ -二磷酸葡萄糖酸三胺盐合成工艺路线路线简述
📜吗啡置于吗啉,Aluminum (III) Chloride,水,正丁胺,Calcium Hydroxide体系中,用 氯仿,乙二醇,异丙醇,乙腈 用作溶剂,化学反应 23.5H,反应生成吗啡-3-β-D-葡糖苷酸
参考文献:一种吗啡衍生物的合成方法及应用
标题:一种吗啡衍生物的合成方法及应用
摘要:本发明公开了一种吗啡衍生物的合成方法,该方法以吗啡为起始原料,经选择性保护和糖基化,从而得到目的产物;本发明合成方法得到的m3G,其HPLC的纯度可以达到99.8%,可以作为相关产品质量研究时的对照品或标准品使用.
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2902700000-异丙基苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-5908927-A
优先权日:1996-05-22
标 题 :Synthesis of deuterated opiate glucuronides
发明人：NGUYEN HOA DUC; NGUYEN DUC TIEN; SCHEP RAYMOND ALBERT; NGUYEN TRINH DUC; PHAM PHUONG THI NGOC
权利人:HIGH STANDARD PRODUCTS CORP
摘要:A method of synthesizing deuterated morphine-3β-glucuronide, morphine-6β-glucuronide, and codeine-6β-glucuronide is disclosed. The chemicals are used as internal standards for mass spectrometry analyses of morphine, heroin, and codeine uses. They are also useful in the study of metabolism of morphine and codeine.
专利号:WO-2005117589-A1
优先权日:2004-05-28
标题:Synthesis of metabolically stable analgesics, pain medications and other agents
专利号:JP-2008501036-A
优先权日:2004-05-28
标题 :Metabolic stable analgesics, pain pharmacotherapy and synthesis of other substances
专利号:JP-2012254984-A
优先权日:2004-05-28
标题 :Metabolic stable analgesics, pain pharmacotherapy and synthesis of other substances
专利号:EP-1758452-A4
优先权日:2004-05-28
标题:SYNTHESIS OF METABOLIC STABLE ANALGETICS, DISEASES OF MEDICAMENTS AND OTHER ACTIVE SUBSTANCES
专利号:JP-5266492-B2
优先权日:2004-05-28
标 题:Metabolic stable analgesics, pain pharmacotherapy and synthesis of other substances
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
摘要:Tested as SID 103416295 in AID 781326:
参考文献:10.1007/bf00178720
摘要:Löser SV, Meyer J, Freudenthaler S, Sattler M, Desel C, Meineke I, Gundert-Remy U. Morphine-6-O-beta-D-glucuronide but not morphine-3-O-beta-D-glucuronide binds to mu-, delta- and kappa- specific opioid binding sites in cerebral membranes. Naunyn Schmiedebergs Arch Pharmacol. 1996 Jul;354(2):192–7. doi: 10.1007/bf00178720.
参考文献:10.3109/03602539608994011
摘要:Milne RW, Nation RL, Somogyi AA. The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine. Drug Metab Rev. 1996 Aug;28(3):345–472. doi: 10.3109/03602539608994011.
参考文献:10.1111/j.1600-0773.1996.tb00253.x
摘要:Aasmundstad TA, Lillekjendlie B, Mørland J. Ethanol interference with morphine metabolism in isolated guinea pig hepatocytes. Pharmacol Toxicol. 1996 Sep;79(3):114–9. doi: 10.1111/j.1600-0773.1996.tb00253.x.
📝 需求与反馈
尽可能描述清楚需求与问题信息
