CAS: 202865-58-5; 1-Bromo-4,5-Difluoro-2-Methoxybenzene

上下游产品

2-bromo-4,5-difluorophenol methyl iodide (4-amino-2-ethylsulfanylpyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone (4-amino-2-ethylsulfanylpyrimidin-5-yl)(4,5-difluoro-2-methoxyphenyl)methanone N,O-dimethylhydroxylamine*hydr°Chloride [2-(4,5-difluoro-2-methoxy-phenyl)-6-methoxy-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

📜2-溴-4,5-二氟苯酚,碘甲烷置于potassium Carbonate体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 4.0H,以1.16 G的收率获得2-溴-4,5-二氟苯甲醚
参考文献: Novel Tetrahydropyridopyrimidines And Tetrahydropyridopyridines For The Treatment And Prophylaxis Of Hepatitis B Virus Infection[fr] Nouvelles Tétrahydropyridopyrimidines Et Tétrahydropyridopyridines Pour Le Traitement Et La Prévention D'Une Infection Par Le Virus De L'Hépatite B
标题: Novel Tetrahydropyridopyrimidines And Tetrahydropyridopyridines For The Treatment And Prophylaxis Of Hepatitis B Virus Infection[fr] Nouvelles Tétrahydropyridopyrimidines Et Tétrahydropyridopyridines Pour Le Traitement Et La Prévention D'Une Infection Par Le Virus De L'Hépatite B
摘要:这项发明提供了具有一般式(i)的新化合物:其中r1,R2,R3,Q,U,W,Z,X和y如本文所述,包括这些化合物的组合物以及使用这些化合物的方法.这些化合物是hbsag抑制剂,可用作治疗或预防hbv感染的药物.

专利信息

专利号:US-7615634-B2
优先权日:2003-02-10
标题:4-aminopyrimidine-5-one derivatives
发明人：BARTKOVITZ DAVID JOSEPH; CHU XIN-JIE; DING QINGJIE; JIANG NAN; LOVEY ALLEN JOHN; MOLITERNI JOHN ANTHONY; MULLIN JR JOHN GUILFOYLE; VU BINH THANH; WOVKULICH PETER MICHAEL
权利人:HOFFMANN LA ROCHE
摘要:Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.