CAS: 19099-54-8; 1-Iodo-2-Isopropylbenzene

该化合物是一种芳香有机化合物,在异丙基苯(CUPI) 框架上有一个替代碘的替代物.这种卤化衍生物是有机合成的多用途中间体,特别是在诸如铃木-宫浦和尼基什等交叉反应中,其碘合金有助于高效的债券形成.它的稳定性和再活性使得它对于在制药,农用化学品和材料科学中构建复杂的分子结构具有价值.该化合物的界定明确的结构和与催化变异的兼容性提高了其在精确合成中的效用.建议由于对光和湿度的敏感性而在惰性条件下进行适当处理.

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CAS号7073-94-1 1-溴-2-异丙基苯 | CAS号7553-56-2 碘 | CAS号98-82-8 异丙基苯 | CAS号643-28-7 2-异丙基苯胺 | CAS号591-50-4 碘苯 | CAS号98-82-8 异丙基苯 | CAS号92-52-4 联苯 | CAS号19486-60-3 2-Isopropyl-1,1... | CAS号25364-40-3 1-(2-propan-2-y... | CAS号6502-22-3 2-异丙基苯甲醛 | CAS号31539-92-1 2-Iodo-5-nitroi... | CAS号75659-50-6 1-乙炔-2-(1-甲基乙基)苯 | CAS号89115-86-6 2-(2-propan-2-y... | CAS号60998-16-5 (2-异丙基苯基)二苯基膦 | CAS号40751-52-8 2-propan-2-ylbe...

合成工艺路线路线简述

    📜4--Phenylphenol Xtosylate置于氯化镍二甲氧基乙烷,碘,2,3-双(2,6-二异丙苯亚氨基)丁烷体系中,用 1,2-二溴乙烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 20.17H,反应生成2-碘异丙基苯
    参考文献:镍二氮杂二烯配合物生成有机锌试剂催化了将锌插入芳基磺酸盐中.
    标题:镍二氮杂二烯配合物生成有机锌试剂催化了将锌插入芳基磺酸盐中.
    摘要:通过将锌直接插入arx亲电试剂的cx键中来生成芳基锌试剂(arznx)通常仅限于碘化物和溴化物.锌粉插入各种芳基磺酸盐(甲苯磺酸盐,甲磺酸盐,三氟甲磺酸盐,磺酸盐)的co键中,或插入其他中等亲电试剂(x = Cl,Sme)的cx键中均通过简单的nicl2-1,4-催化二氮杂二烯催化剂体系,其中1,4-二氮杂二烯(dad)代表二乙酰基二亚胺,菲咯啉,联吡啶和相关配体.现在,在室温下在dmf或nmp溶液中进行催化锌化可提供芳基锌磺酸盐,这些芳基锌磺酸盐会经历典型的催化交叉偶联或亲电取代反应.
    Doi:10.1002/chem.201904545

    海关参考信息

    专利信息


    专利号:US-6458967-B1
    优先权日:2000-06-26
    标 题:Method for preparation of an intermediate dye product
    发明人:DETTY MICHAEL RAY; VIRKLER PETER ROBERT
    权利人:UNIV NEW YORK STATE RES FOUND
    摘要:The present invention provides a novel method for the synthesis of an intermediate dye product having the following formula: n wherein n L is S, Te, or Se; n R 1 and R 2 are either the same or different aryl or alkyl compounds; n R 3 is hydrogen or a short chain alkyl group; and n Z is an anion. n The process to formulate this intermediate compound entails reacting an R 1 -acetylene compound with an R 2 -acetylene compound (compounds A) into an enol ether compound with the R 1 and/or R 2 constituents (compound D). And from compound D, it forms into an intermediate dye compound having an L-based cyclic ring with the R 1 and/or R 2 constituents (compound F). With compound F the desired dye can be made with a greater overall yield for mass production.

    专利号:US-2023295139-A1
    优先权日:2020-07-21
    标题 :Synthesis of heterocyclic compounds from carboxamide and carboxamide derivatives with haloalkanols

    专利号:WO-2020223551-A1
    优先权日:2019-04-30
    标 题 :Inhibiting otub1
    发明人:MARCIN Lawrence; KAYSER-BRICKER KATHERINE
    权利人:INTEGRAL EARLY DISCOVERY INC; INTEGRAL HEALTH HOLDINGS LLC
    摘要:The present disclosure is directed to compounds of formulas (I) - (VII), which are useful as modulators of OTUB1. The compounds are further useful in the inhibition of OTUB1 and the treatment of diseases or disorders associated with the inhibition of OTUB1. For instance, the disclosure is concerned with compounds and compositions for inhibition of OTUB1, methods of treating diseases associated with the inhibition of OTUB1 (e.g., inflammatory diseases like irritable bowel disease and Lupus), and methods of synthesis of these compounds.

    专利号:CN-113087691-B
    优先权日:2021-03-26
    标题:A method for the synthesis of chiral aryl tertiary alcohols and benzopyrans based on a kinetic resolution strategy

    专利号:CN-113087691-A
    优先权日:2021-03-26
    标 题:A method for the synthesis of chiral aryl tertiary alcohols and benzopyrans based on kinetic resolution strategy

    专利号:CN-114716439-A
    优先权日:2022-04-26
    标题 :A method of copper-catalyzed synthesis of 6-thiopurine derivatives

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Palladium-Catalyzed Cascade Ch Trifluoroethylation Of Aryl Iodides And Heck Reaction: Efficient Synthesis OfOrtho-Trifluoroethylstyrenes
    作者:Hao Zhang,Pinhong Chen,Guosheng Liu |发布日期:2014.9.15
    摘要:A Palladium‐catalyzed Selective Ch Bond Trifluoroethylation Of Aryl Iodides Has Been Explored. The Reaction Allows For The Efficient Synthesis Of A Variety Of Ortho‐trifluoroethyl‐substituted Styrenes. Preliminary Mechanistic Studies Indicate That The Reaction Might Involve A Key Pdiv Intermediate, Which Is Generated Through The Rate‐determining Oxidative Addition Of Cf3Ch2I To A Palladacycle; The

    合成参考文献


    摘要:González-Bello, C., Science of Synthesis Knowledge Updates, (2018) 1, 233.
    摘要:Murata, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 475.
    摘要:Eichman, C. C.; Stambuli, J. P., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 372.
    摘要:Das, A.; Ramkumar, N.; Veliks, J., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2.
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