CAS: 1877-72-1; 3-Cyanobenzoic Acid

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CAS号620-22-4 间甲基苯腈 | CAS号3441-01-8 3-氰基苯甲酰胺 | CAS号6952-59-6 间溴苯甲腈 | CAS号201230-82-2 carbon monoxide | CAS号766-84-7 3-氯苯腈 | CAS号67-56-1 甲醇 | CAS号124-38-9 二氧化碳 | CAS号626-17-5 间苯二甲腈 | CAS号10406-24-3 3-氨甲基-苯甲腈 | CAS号24964-64-5 3-氰基苯甲醛 | CAS号363186-09-8 3-Cyano-N-methy... | CAS号34231-22-6 3-(氨甲基)苯甲醇 | CAS号6068-72-0 4-氰基苯甲酰氯 | CAS号1711-11-1 3-氰基苯甲酰氯 | CAS号27020-96-8 3-三氯甲基苯甲腈 | CAS号874-97-5 3-羟甲基苯甲腈 | CAS号93071-65-9 3-(氨甲基)苯甲酸甲酯 | CAS号876-03-9 3-氨甲基苯甲酸盐酸盐 | CAS号73096-39-6 3-(1H-四唑-5-基)苯甲酸 | CAS号1016521-87-1 3-(5-Amino-1,3,...

间苯二甲腈置于sodium Hydroxide,硫酸,Sodium Nitrite体系中,用 水 用作溶剂,以52%的收率获得3-氰基苯甲酸
参考文献:Process For Producing Cyanobenzoic Acid Derivatives
标题:Process For Producing Cyanobenzoic Acid Derivatives
摘要:生产氰苯甲酸化合物,氰苯酰胺化合物,烷基氰苯酸酯化合物和氰苯甲酰氯化合物的方法,这些化合物是制药,农药,液晶和功能性聚合物单体等各种化学品的有用中间体.易得的邻苯二腈化合物的一个腈基被选择性水解,从而高选择性和产率地产生氰苯酰胺化合物.因此产生的氰苯酰胺化合物在酸性条件下转化为氰苯甲酸化合物和氰苯酸酯化合物,而苯环的腈基不会受损.

专利信息

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-9388147-B2
优先权日:2009-11-13
标题 :Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人：MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TIMONY GREGG ALAN; BROOKS JENNIFER L; PEACH ROBERT; SCOTT FIONA LORRAINE; HANSON MICHAEL ALLEN
权利人:RECEPTOS INC; CELGENE INTERNAT II SÃ?RL
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-8778958-B2
优先权日:2008-07-10
标题 :Synthesis of metabolically stable agents for alcohol and drug abuse
发明人：CASHMAN JOHN R
权利人:CASHMAN JOHN R
摘要:The disclosed opioid-related compounds and pharmaceutical compositions thereof, are useful in a variety of applications relating to the modulation of receptors and receptor signaling within and outside the nervous system. For example, the compounds and compositions are useful in methods for the treatment of addictions and other CNS-related disorders. The disclosed compounds can be delivered or administered to a mammal including humans, alone in the form of a pharmaceutically acceptable salt or hydrolysable precursor thereof, or in the form of a pharmaceutical composition, wherein a therapeutically effective amount of a compound is mixed with suitable carriers or excipients.

专利号:WO-9426779-A1
优先权日:1993-05-13
标 题 :PROCESSES AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS
发明人：MADUSKUIE THOMAS PETER JR
权利人:DU PONT MERCK PHARMA
摘要:This invention provides processes and intermediates for the synthesis of platelet glycoprotein IIb/IIIa inhibitors of formula (I).

专利号:US-5817749-A
优先权日:1993-03-29
标 题:Processes and intermediate compounds for the preparation of platelet glycoprotein IIb/IIIa inhibitors
发明人：ZHANG LIN-HUA; MA PHILIP; DEGRADO WILLIAM FRANK
权利人:DU PONT PHARM CO
摘要:This invention provides processes for the synthesis of platelet glycoprotein IIb/IIIa inhibitors and intermediate compounds useful in said processes. The compounds afforded by this invention have the formula: Formula (I)

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).