CAS: 1455-20-5; 2-Butylthiophene

该化合物是一种七环有机化合物,由二号位置的丁基苯环替代,在二号位置上以丁基组替代一丁基苯环,该化合物通常用作有机合成的中间体,特别是在制药,农用化学品和特殊化学品的生产方面,其结构允许进一步功能化,使其在复杂分子的开发中具有价值.丁基边链会增强有机溶剂的溶性,促进其在各种反应条件下的使用.此外,二丁基苯基在典型的加工条件下表现出稳定性,确保合成应用的可靠性能.其一贯的纯度和特性使得它成为需要精确的硫苯衍生物的研究和工业工艺的首选.

结构式图片

相似化合物

4861-58-9 1551-27-5 18794-77-9

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号188290-36-0 Thiophene(SIV) | CAS号109-65-9 正溴丁烷 | CAS号5333-83-5 2-正丁酰噻吩 | CAS号542-69-8 碘代正丁烷 | CAS号5713-61-1 2-噻吩基溴化镁 | CAS号106-99-0 丁二烯 | CAS号693-03-8 正丁基溴化镁 | CAS号3141-27-3 2,5-二溴噻吩 | CAS号1003-09-4 2-溴噻吩 | CAS号4411-80-7 6,6′-二甲基-2,2′-联吡啶 | CAS号1062177-17-6 2-(5-butylthiop... | CAS号32364-72-0 [2,2’]-双噻吩-5,5‘-二甲醛 | CAS号1062177-05-2 5'-butyl-2,2'-b... | CAS号33566-59-5 4-Ketododecanoi... | CAS号143-08-8 1-壬醇 | CAS号18494-73-0 5,5-二乙酰基-2,2-联噻吩 | CAS号1062177-10-9 1-(5'-butyl-2,2... | CAS号64964-19-8 2-Thiophenecarb... | CAS号98954-25-7 5-丁基噻吩-2-甲醛

合成工艺路线路线简述

    📜2-正丁酰噻吩置于氢氧化钾,一水合肼,乙二醇体系中,化学反应生成2-正丁基噻吩
    参考文献:Profft,Chemiker-Zeitung,Chemische Apparatur,1958,Vol. 82,P. 295,297
    标题:Profft,Chemiker-Zeitung,Chemische Apparatur,1958,Vol. 82,P. 295,297

    海关参考信息

    专利信息


    专利号:US-2008086013-A1
    优先权日:2006-06-15
    标 题:Carbometallation of alkynes and improved synthesis of uniquinones
    发明人:LIPSHUTZ BRUCE H
    权利人:UNIV CALIFORNIA
    摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.

    专利号:US-8476441-B2
    优先权日:2009-01-29
    标 题 :Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid
    发明人:CONNON STEPHEN JOSEPH; PESCHIULLI ALDO; MARKEY LYN
    权利人:CONNON STEPHEN JOSEPH; PESCHIULLI ALDO; MARKEY LYN; TRINITY COLLEGE DUBLIN
    摘要:(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pain and pain in patients with fibromyalgia. Provided herein are thioester intermediates in the synthesis of and processes for the synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid in the (R) or (S) configuration.

    专利号:US-8450365-B2
    优先权日:2009-05-12
    标 题 :Efficient synthesis of galanthamine
    发明人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ
    权利人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ; UNIV TEXAS
    摘要:The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

    专利号:WO-2017051326-A1
    优先权日:2015-09-23
    标 题 :New processes and intermediates useful in synthesis of nep inhibitors
    发明人:MARTIN BENJAMIN; PENN GERHARD; SCHENKEL BERTHOLD; BOURNE SAMUEL; LAU SHING-HING; LEY Steven
    权利人:NOVARTIS AG; MARTIN BENJAMIN; PENN GERHARD; SCHENKEL BERTHOLD; BOURNE SAMUEL; LAU SHING-HING; LEY Steven
    摘要:The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors such as sacubitril, and prodrugs thereof.

    专利号:US-2014199585-A1
    优先权日:2013-01-17
    标 题 :Low Symmetry Molecules And Phosphonium Salts, Methods Of Making And Devices Formed There From
    发明人:RUPERT BENJAMIN L; BEER LEANNE
    权利人:ESIONIC ES INC
    摘要:Synthesis of molecules and salts is disclosed having low average symmetry and their use in many applications, including but not limited to: as electrolytes in electronic devices such as memory devices including static, permanent and dynamic random access memory, as electrolytes in energy storage devices such as batteries, electrochemical double layer capacitors (EDLCs) or supercapacitors or ultracapacitors, electrolytic capacitors, as electrolytes in dye-sensitized solar cells (DSSCs), as electrolytes in fuel cells, as a heat transfer medium, high temperature reaction and/or extraction media, among other applications. In particular, synthesis methods and processes to form molecules and salts having low average symmetry using mixed Grignard reagents are disclosed.

    专利号:US-6004787-A
    优先权日:1991-01-17
    标题:Method of directing biosynthesis of specific polyketides
    发明人:KATZ LEONARD; DONADIO STEFANO; MCALPINE JAMES B
    权利人:ABBOTT LAB
    摘要:A method to produce novel polyketide structures by designing and introducing specified changes in the DNA governing the synthesis of the polyketide is disclosed. The biosynthesis of specific polyketide analogs is accomplished by genetic manipulation of a polyketide-producing microorganism by isolating a polyketide biosynthetic gene-containing DNA sequence, identifying enzymatic activities associated within the DNA sequence, introducing one or more specified changes into the DNA sequence which codes for one of the enzymatic activities which results in an altered DNA sequence, introducing the altered DNA sequence into the polyketide-producing microorganism to replace the original sequence, growing a culture of the altered microorganism under conditions suitable for the formation of the specific polyketide analog, and isolating the specific polyketide analog from the culture. The method is most useful when the segment of the chromosome modified is involved in an enzymatic activity associated with polyketide biosynthesis, particularly for manipulating polyketide synthase genes from Saccarharopolyspora or Streptomyces.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Heterogeneously Catalyzed Direct Ch Thiolation Of Heteroarenes
    作者:Suhelen Vásquez-Céspedes,Angélique Ferry,Lisa Candish,Frank Glorius |发布日期:2015.5.4
    摘要:The First General Methodology For The Direct Thiolation Of Electron‐rich Heteroarenes Was Developed By Employing Pd/al2O3, A Recoverable And Commercially Available Heterogeneous Catalyst, And Cucl2. This Method Represents An Operationally Simple Approach For The Synthesis Of These Valuable Compounds. Preliminary Mechanistic Studies Indicate A Heterogeneous Catalytic System, In Which Both Metals Play

    合成参考文献


    摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 394.
    摘要:Stanforth, S. P., Science of Synthesis Knowledge Updates, (2015) 1, 219.
    摘要:Wolf, C., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 887.
    摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 367.
    摘要:Sanz, R.; Su, Science of Synthesis: Knowledge Updates, (2024) 1, 105.
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