CAS: 135531-86-1; 3-(1,3-Thiazol-2-yl)-1H-Indole
该化合物是一种天然的藻类,主要见于植物,特别是芥子类植物(Brassicaceae)中.它因其作为植物针对病原体攻击而生产的化合物,即植物为辅助其防御机制而生产的植物的植物,而作为植物的植物,其作用得到承认.从化学角度讲,卡马林的特点是其无脊椎结构,这是一种双环化合物,由一种苯环组成,与一个火花环结合.这一结构对其生物活动意义重大,因为它表现出抗微生物特性,对抗包括真菌和细菌在内的各种病原体.卡马林的抗氧化特性也为人们所熟知,这可能有助于减轻植物中的氧化性压力.在植物中的合成往往是环境压力,例如感染或伤害,突出其对植物免疫的重要性.此外,对卡马林的研究揭示了在农业和医学中的潜在应用,特别是在开发天然杀虫剂或治疗剂方面.
- 英文名称3-(1,3-Thiazol-2-yl)-1H-Indole
- 中文名称拟南芥植保素
- IUPAC名称2-(1H-indol-3-yl)thiazole
- 其它别名1H-Indole, 3-(2-Thiazolyl)-; Qy3Z69La99; 3-Thiazol-2'-Yl-Indole; 3-(Thiazol-2-yl)Indole; 3-(Thiazol-2-yl)-1H-Indole; 2-(1H-Indol-3-yl)-1,3-Thiazole; 3-(2-Thiazolyl)-1H-Indole; Camal
- CAS编号135531-86-1
- MFCD编号:MFCD18451889
- EINECS号:808-542-7
- FDA UNII编号:QY3Z69LA99
- 分子式:C11H8N2S分子量:200.27
- 产品CID: 556226
- 产品分类Chemistry → Heterocyclic Building Blocks → Aromatic Heterocycles | Inhibitors/Agonists → Anti-infection → Antifungal | Inhibitors/Agonists → Immunology/Inflammation → ROS | Inhibitors/Agonists → Anti-infection → Antibacterial
物理性质
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
- 合成目标产物 Camalexin 主要起始原料 2-Bromothiazole And Indole
- (文献来源)合成步骤主要原料 2-Bromothiazole 和 Indole
海关参考信息
- 2902200000-苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7241900-B2
优先权日:2002-02-12
标题 :Synthesis of indole thiazole compounds as ligands for the Ah receptor
发明人：DELUCA HECTOR F; GRZYWACZ PAWEL K; SICINSKI RAFAL R
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A method of synthesizing aromatic ketone compositions of formula I comprising the step of introducing a double bond into the 5 membered ring of the 4,5-dihydro-1,3-azoles moiety of formula II is disclosed. A method of synthesizing aromatic ketone compositions of formula I comprising the step of ring synthesis of the tetrahydro-1,3-azoles of formula XI is also disclosed.
专利号:US-2004204588-A1
优先权日:2002-02-12
标题 :Synthesis of indole thiazole compounds as ligands for the Ah receptor
专利号:CN-1642910-A
优先权日:2002-02-12
标 题:Synthesis of Indolethiazole Compounds for AH Receptors as Ligands
专利号:EP-1480951-A1
优先权日:2002-02-12
标题:Synthesis of indole thiazole compounds as ligands for the ah receptor
专利号:WO-03068742-A1
优先权日:2002-02-12
标题:Synthesis of indole thiazole compounds as ligands for the ah receptor
专利号:US-2006079692-A1
优先权日:2002-02-12
标题:Synthesis of indole thiazole compounds as ligands for the Ah receptor
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Glawischnig E. Camalexin. Phytochemistry. 2007 Feb;68(4):401-6. doi: 10.1016/j.phytochem.2006.12.005. Epub 2007 Jan 10. 255(6):116. doi: 10.1007/s00425-022-03907-1. 76(1):110-118. doi: 10.1007/s11418-021-01560-8. Epub 2021 Aug 31.
2018:7426950. doi: 10.1155/2018/7426950.
5: Rauhut T, Glawischnig E. Evolution of camalexin and structurally related indolic compounds. Phytochemistry. 2009 Oct-Nov;70(15-16):1638-44. doi: 10.1016/j.phytochem.2009.05.002. Epub 2009 Jun 10. 73(11):3743-3757. doi: 10.1093/jxb/erac070. 31(11):2697-2710. doi: 10.1105/tpc.19.00403. Epub 2019 Sep 11.
合成参考文献
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 172.
摘要:Koutentis, P. A.; Ioannidou, H. A., Science of Synthesis Knowledge Updates, (2010) 1, 359.
参考文献:10.1073/pnas.0305876101
摘要:Glawischnig E, Hansen BG, Olsen CE, Halkier BA. Camalexin is synthesized from indole-3-acetaldoxime, a key branching point between primary and secondary metabolism in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 2004 May 17;101(21):8245–50. doi: 10.1073/pnas.0305876101.
参考文献:10.1104/pp.106.082024
摘要:Schuhegger R, Nafisi M, Mansourova M, Petersen BL, Olsen CE, Svatos A, Halkier BA, Glawischnig E. CYP71B15 (PAD3) catalyzes the final step in camalexin biosynthesis. Plant Physiol. 2006 Aug;141(4):1248–54.
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