CAS: 134394-98-2; 1,1-Dimethylethyl (R)-7-(2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-Phenyl-4-((Phenylamino)Carbonyl)-1H-Pyrrol-1-yl)-5-Hydroxy-3-Oxo-1-Heptanoate

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acetic acid tert-butyl ester -1H-pyrrol-1-yl>-3-hydroxy-1-pentanoatemethyl (R)-(+)-5-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylamino)carbonyl-1H-pyrrol-1-yl-3-hydroxy-1-pentanoate ethyl 3-(4-cyanophenyl)propynoate *,S*)>-5--1H-pyrrol-1-yl>-3-hydroxy-1-pentanoic acid, 2-hydroxy-1,2,2-triphenylethyl ester*,S*)-5-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylamino)carbonyl-1H-pyrrol-1-yl-3-hydroxy-1-pentanoic acid, 2-hydroxy-1,2,2-triphenylethyl ester atorvastatin lactone lipitor

📜乙酸叔丁酯锂烯醇化物置于咪唑,三甲基氯硅烷,溶剂黄146体系中,用 四氢呋喃,甲苯,水 用作溶剂,化学反应 9.75H,反应生成(R)-叔-丁基7-(2-(4-氟苯基)-5-异丙基-3-苯基-4-(苯氨羰基)-1H-吡咯-1-基)-5-羟基-3-氧亚基庚酯
参考文献:Process For The Preparation Of Atorvastatin And Intermediates
标题:Process For The Preparation Of Atorvastatin And Intermediates
摘要:提供了一种制备(R)-5-[2-(4-氟苯基)-5-(1-甲基乙基)-3-苯基-4-[(苯基氨基)羰基]-1H-吡咯-1-基]-5-羟基-3-氧代-1-庚酸,R-取代酯9的过程,包括:(A)将醛1与(S)-2-羟基-1,2,2-三苯乙基醋酸酯取代物的烯醇形式在螯合共溶剂中反应;(B)水解(R,S)-5-[2-(4-氟苯基)-5-(1-甲基乙基)-3-苯基-4-[(苯基氨基)羰基]-1H-吡咯-1-基]-3-羟基-1-戊酸,(S)-2-羟基-1,2,2-三苯乙基酯(2A和2B)使用碱,优选为碱金属碱,优选在溶剂中形成羧酸7;(C)用手性碱处理酸7以形成盐并纯化盐以获得对映富集的(R)-7手性碱盐;(D)烷基化(R)-7手性碱盐或由(R)-7衍生的游离碱,形成(R)-5-[2-(4-氟苯基)-5-(1-甲基乙基)-3-苯基-4-[(苯基氨基)羰基]-1H-吡咯-1-基]-5-羟基-3-氧代-1-庚酸,R-取代酯9和阿托伐他汀钙6,其中r是c1到c6烷基,C6到c9芳基或c7到c10芳基甲基.